Epidemiology and Health

Perspective

Interpretation of the hygiene and microflora hypothesis for allergic diseases through epigenetic epidemiology: Jong-Myon Bae; Epidemiol Health. 2018;40:e2018006. Published online March 10, 2018; DOI: https://doi.org/10.4178/epih.e2018006

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Abstract

The hygiene hypothesis (HH) proposed by Strachan in 1989 was expanded to explain the inverse association between the occurrence of allergy disorders and the risk of infectious diseases and parasite infestation. The microflora hypothesis (MH) suggests that gut microbial dysbiosis in early life might trigger hypersensitivity disorders. The sharing concept of both HH and MH is gene-environment interaction, which is also a key concept in epigenetics. The amalgamation of epidemiology and epigenetics has created a scientific discipline termed epigenetic epidemiology. To accomplish an era of gene-environment-wide interaction studies, it is necessary to launch a national human epigenome project.

Summary

Korean summary
1989년 제시된 위생가설 (Hygiene hypothesis)은 최근 체내미생물가설 (Microflora hypothesis) 대치되어 알레르기 질환의 발생기전을 해석하고 있다. 두 가설 모두 유전-환경 상호작용 gene-environment interaction) 을 강조하고 있다는 점에서 향후 후성유전역학 연구에 대한 활성화가 필요하다.

Citations

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Hypothesis

The necessity of an observational study on the interactions between allergic history and citrus fruit intake for the prevention of pancreatic cancer: Jong-Myon Bae; Epidemiol Health. 2015;37:e2015028. Published online June 16, 2015; DOI: https://doi.org/10.4178/epih/e2015028

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Abstract Summary PDF Supplementary Material

Abstract

While the main product of Jeju Island is citrus fruit and the prevalence of atopic dermatitis among the students who live there is relatively high, the incidence of pancreatic cancer is lowest in Korea. Systematic reviews reporting allergic history and intake of citrus fruit as protective factors against pancreatic cancer (PCC) were published in 2005 and 2008, respectively. Although there were discrepancies in the results of the subgroup analyses between case-control and cohort studies, it is necessary to evaluate an interaction effect between allergic history and intake of citrus fruits on PCC risk.

Summary

Korean summary
췌장암 발생과 관련한 요인들의 규명이 절실한 상황에서, 알레르기 질환과 감귤섭취 각각이 발생억제 효과가 있다는 체계적 고찰연구가 있다. 그러나 코호트 연구들만으로 메타분석을 하였을 때는 두 억제 요인 모두 통계적 유의성이 없는 것으로 나왔다. 한편 지역별 췌장암 발생률에서 낮은 수준을 보이는 제주도는 주요 감귤생산지이면서, 초중고등학생의 아토피 유병률이 상대적으로 높은 것으로 알려져 있다. 이런 사실들에 근거할 때 췌장암 발생에 있어 알레르기질환과 감귤섭취의 상호작용을 규명하는 코호트 연구를 제안한다.

Citations

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Citation Discovery Tools for Conducting Adaptive Meta-analyses to Update Systematic Reviews
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Journal of Preventive Medicine and Public Health.2016; 49(2): 129. CrossRef
Hormonal Replacement Therapy and the Risk of Lung Cancer in Women: An Adaptive Meta-analysis of Cohort Studies
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Journal of Preventive Medicine and Public Health.2015; 48(6): 280. CrossRef
Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis
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Epidemiology and Health.2015; 37: e2015052. CrossRef
Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review
Jong-Myon Bae, Eun Hee Kim
Journal of Preventive Medicine and Public Health.2015; 48(5): 225. CrossRef

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