Skip Navigation
Skip to contents

Epidemiol Health : Epidemiology and Health

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
2 "Sook-Hyang Jeong"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Article
Epidemiology and treatment status of hepatitis C virus infection among people who have ever injected drugs in Korea: a prospective multicenter cohort study from 2007 to 2019 in comparison with non-PWID
Kyung-Ah Kim, Gwang Hyun Choi, Eun Sun Jang, Young Seok Kim, Youn Jae Lee, In Hee Kim, Sung Bum Cho, Moran Ki, Hwa Young Choi, Dahye Paik, Sook-Hyang Jeong
Epidemiol Health. 2021;43:e2021077.   Published online October 6, 2021
DOI: https://doi.org/10.4178/epih.e2021077
  • 11,037 View
  • 261 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract AbstractSummary PDF
Abstract
OBJECTIVES
Injection drug use is a major risk factor for hepatitis C virus (HCV) infection; however, limited data on this topic are available in Korea. Thus, this study aimed to investigate the epidemiological and clinical characteristics, treatment uptake, and outcomes of HCV infection among people who inject drugs (PWID).
METHODS
We used the data from the Korea HCV cohort, which prospectively enrolled patients with HCV infection between 2007 and 2019. Clinical data and results of a questionnaire survey on lifetime risk factors for HCV infection were analyzed according to a self-reported history of injection drug use (PWID vs. non-PWID group).
RESULTS
Among the 2,468 patients, 166 (6.7%) were in the PWID group, which contained younger patients (50.6±8.2 vs. 58.2±13.1 years) and a higher proportion of male (81.9 vs. 48.8%) than the non-PWID group. The distribution of PWID showed significant regional variations. Exposure to other risk factors for HCV infection was different between the groups. The proportion of patients with genotype non-2 infection was higher in the PWID group. Treatment uptake was higher in the PWID group in the interferon era; however, it was comparable between the groups in the direct-acting antiviral era. The rate of sustained virological response did not significantly differ between the groups.
CONCLUSIONS
As of 2019, PWID constituted a minority of HCV-infected people in Korea. The epidemiological characteristics, but not treatment uptake and outcomes, were different between the PWID and non-PWID groups. Therefore, active HCV screening and treatment should be offered to PWID in Korea.
Summary
Korean summary
1. 국내 C형간염 환자 중 정맥주사 사용자의 비율은 6.7%로 서구에 비하면 낮은 편이며, 지역별로 차이가 있다. 2. C형간염 환자 중 정맥주사 사용자는 비사용자에 비하여 연령, 성별 및 C형간염 위험 요인 노출 등에서 상이한 역학적 특성을 보인다. 3. 정맥주사 사용자의 C형간염 치료 수용률이나 치료 성공률은 비사용자와 비슷하다.
Key Message
As of 2019, PWID comprised a minority (6.7%) of all HCV-infected people in South Korea. The epidemiological features of the PWID group were different from those of the non-PWID group in terms of age, sex and exposure to risk factors of HCV infection. However, the treatment uptake and outcomes were not significantly different between these 2 groups in DAA era. Therefore, considering the global and national increase in the number of PWID and the contribution of PWID to new cases of HCV infection, active screening and treatment should be offered to PWID in Korea.

Citations

Citations to this article as recorded by  
  • Prevalence and factors associated with hepatitis C among pregnant women in China: a cross-sectional study
    Sun He, Gao Shuang, Wu Yinglan, Wang Lan, Wang Wei, Wang Ailing, Wang Changhe, Wang Xiaoyan, Gao Qun, Lu Zechun, Huang Dongxu, Wang Yu, Mo Phoenix Kit Han, Chen Zhongdan, Polin Chan, Wang Qian
    Scientific Reports.2023;[Epub]     CrossRef
  • Hepatitis C Virus Seroprevalence in Persons Who Inject Drugs in Korea, 2012–2022: A Multicenter, Retrospective Study
    Jihye Kim, Gwang Hyeon Choi, Og-Jin Jang, Younghoon Chon, Sung Nam Cho, Dohoon Kwon, Sook-Hyang Jeong
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
Editorial
Current status of hepatitis C virus infection and countermeasures in South Korea
Sook-Hyang Jeong, Eun Sun Jang, Hwa Young Choi, Kyung-Ah Kim, Wankyo Chung, Moran Ki
Epidemiol Health. 2017;39:e2017017.   Published online April 13, 2017
DOI: https://doi.org/10.4178/epih.e2017017
  • 25,935 View
  • 372 Download
  • 17 Web of Science
  • 27 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
Hepatitis C virus (HCV) infection is a major cause of liver cirrhosis, hepatocellular carcinoma, and liver-related mortality. The new antiviral drugs against HCV, direct acting antivirals, result in >90% cure rate. This review aimed to summarize the current prevalence, clinical characteristics, outcomes, and treatment response associated with HCV infection, and countermeasures for optimal HCV control in South Korea. Based on a literature review, the current anti-HCV prevalence in the Korean population is 0.6 to 0.8%, with increasing prevalence according to age. The major HCV genotypes in Korean patients were genotype 1b and genotype 2. Successful antiviral treatment leads to significantly reduced liver related complications and mortality. However, only about one third of the individuals with HCV infection seem to be managed under the current national health insurance system, suggesting a remarkable rate of underdiagnoses and subsequent loss of opportunity to cure. A recent study in South Korea showed that targeted population screening for HCV infection is cost-effective. To prevent recently developed clusters of HCV infection in some clinics, mandatory surveillance rather than sentinel surveillance for HCV infection is required and governmental countermeasures to prevent reuse of syringes or other medical devises, and public education should be maintained. Moreover, one-time screening for a targeted population should be considered and a cost-effectiveness study supporting an optimal screening strategy is warranted.
Summary
Korean summary
우리나라 C형간염 유병률은 1% 미만(0.6-0.8%)이며, 수혈에 의한 C형간염은 더 이상 발생하지 않을 것으로 보인다. 그러나 최근 의료기관에서 C형간염 집단감염이 발생하여 국가적 대응이 필요한 공중보건의 문제로 떠올랐다. 2016년 부터는 C형간염을 완치할 수 있는 효과적이고 안전한 약제가 건강보험급여로 인정되어 이미 진단된 환자들에서는 효과적인 치료가 시작되었다. 그러나 진단되지 않은 상태에서 간질환이 진행되고 있는 환자들을 발굴하기 위해 국가 검진체계와 연계하여 선별검사를 시행한다면, 단기적으로는 진단과 치료비용 부담이 커지겠지만 장기적으로 사망률을 감소시키고, 삶의 질을 높이는 비용효과적인 C형간염 퇴치 전략이 될 것이다.

Citations

Citations to this article as recorded by  
  • Treatment Outcomes of HCV Infection in People Living with HIV: A Case Series from a Single Center in Korea
    Shinwon Lee, Jeong Eun Lee, Soon Ok Lee, Sun Hee Lee
    Infection & Chemotherapy.2024; 56(3): 386.     CrossRef
  • Changing trends in the incidence and spectrum of cancers between 1990 and 2021 among HIV-infected patients in Busan, Korea
    Soon Ok Lee, Jeong Eun Lee, Yong Ki Sim, Shinwon Lee, Woo Seog Ko, Jinmi Kim, Jin Suk Kang, Hyunjin Son, Sun Hee Lee
    Journal of Infection and Chemotherapy.2023; 29(6): 571.     CrossRef
  • Next-generation sequencing analysis of hepatitis C virus resistance–associated substitutions in direct-acting antiviral failure in South Korea
    Kyung-Ah Kim, Sejoon Lee, Hye Jung Park, Eun Sun Jang, Youn Jae Lee, Sung Bum Cho, Young Suk Kim, In Hee Kim, Byung Seok Lee, Woo Jin Chung, Sang Hoon Ahn, Seungtaek Kim, Sook Hyang Jeong
    Clinical and Molecular Hepatology.2023; 29(2): 496.     CrossRef
  • Treatment of Chronic Hepatitis C in Older Adults
    Jong Eun Yeon
    Korean Journal of Clinical Geriatrics.2023; 24(3): 93.     CrossRef
  • Effect of Disease-related Knowledge and Health Enhancement Lifestyle on Self-management Behavior among Chronic Hepatitis C Patients
    Hoo Jeung CHO, Euna PARK
    THE JOURNAL OF FISHERIES AND MARINE SCIENCES EDUCATION.2022; 34(2): 219.     CrossRef
  • Assessing the Effectiveness and Safety of Direct-acting Antiviral Treatment in Korean Patients with Hepatitis C Virus Genotype 1b or 2 at a Tertiary Care Hospital
    Mi Seon Park, Young-Mo Yang, Ki Hyun Park, Hyonok Yoon, Ju Sin Kim, Eun Joo Choi
    Korean Journal of Clinical Pharmacy.2022; 32(3): 191.     CrossRef
  • Analysis of Hepatitis C Virus Genotypes and RNA Quantitative Values in Cheonan, Republic of Korea from 2007 to 2016
    Bishguurmaa Renchindorj, Bo Kyeung Jung, Joowon Park
    Microbiology and Biotechnology Letters.2022; 50(3): 422.     CrossRef
  • Comparative evaluation of Elecsys, Atellica, and Alinity assays for measuring the anti-Hepatitis C virus (HCV) antibody
    Youn Keong Cho, Sinyoung Kim, Hyun Ok Kim, Da Som Choi, Hyon-Suk Kim, Younhee Park
    Journal of Clinical Virology.2021; 141: 104910.     CrossRef
  • Performance Evaluation of Aptima HBV and HCV Quant Assays in the Panther System
    Yu Jeong Choi, Boyeon Kim, Yoonjung Kim, Kyung-A Lee
    Laboratory Medicine Online.2021; 11(3): 177.     CrossRef
  • Inclusion of hepatitis C virus testing in National Health Screening to accelerate HCV elimination in South Korea
    Youngmee Jee
    Global Health & Medicine.2021; 3(5): 288.     CrossRef
  • Clinical Characteristics and Treatment Outcomes of Patients with Hepatitis C Virus and Human Immunodeficiency Virus Coinfection: Experience at a Single Center in Korea
    Dae Hyun Lim, Jae Yoon Jeong, Seongwoo Nam, Jongkyoung Choi, Hyeok Choon Kwon, Yong Bum Yoon, Yeonjae Kim, BumSik Chin
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Efficacy and Safety of Glecaprevir/Pibrentasvir in Korean Patients with Chronic Hepatitis C: A Pooled Analysis of Five Phase II/III Trials
    Jeong Heo, Yoon Jun Kim, Jin-Woo Lee, Ji Hoon Kim, Young-Suk Lim, Kwang-Hyub Han, Sook-Hyang Jeong, Mong Cho, Ki Tae Yoon, Si Hyun Bae, Eric D. Crown, Linda M. Fredrick, Negar Niki Alami, Armen Asatryan, Do Hyun Kim, Seung Woon Paik, Youn-Jae Lee
    Gut and Liver.2021; 15(6): 895.     CrossRef
  • A tool to measure the impact of inaction toward elimination of hepatitis C: A case study in Korea
    Yong Kyun Won, Kyung Sik Kang, Yuri Sanchez Gonzalez, Homie Razavi, Ellen Dugan, Kwang-Hyub Han, Sang Hoon Ahn, Mi Young Jeon, Do Young Kim, Tatsuo Kanda
    PLOS ONE.2020; 15(4): e0232186.     CrossRef
  • Changes in Characteristics of Patients with Liver Cirrhosis Visiting a Tertiary Hospital over 15 Years: a Retrospective Multi-Center Study in Korea
    Won Young Jang, Woo Jin Chung, Byoung Kuk Jang, Jae Seok Hwang, Heon Ju Lee, Moon Joo Hwang, Young Oh Kweon, Won Young Tak, Soo Young Park, Su Hyun Lee, Chang Hyeong Lee, Byung Seok Kim, Si Hye Kim, Jeong Ill Suh, Jun Gi Park
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • Cost‐effectiveness and health‐related outcomes of screening for hepatitis C in Korean population
    Kyung‐Ah Kim, Wankyo Chung, Hwa Young Choi, Moran Ki, Eun Sun Jang, Sook‐Hyang Jeong
    Liver International.2019; 39(1): 60.     CrossRef
  • Cost‐effectiveness of sofosbuvir plus ribavirin therapy for hepatitis C virus genotype 2 infection in South Korea
    Wankyo Chung, Kyung‐Ah Kim, Eun Sun Jang, Moran Ki, Hwa Young Choi, Sook‐Hyang Jeong
    Journal of Gastroenterology and Hepatology.2019; 34(4): 776.     CrossRef
  • The association between hepatitis and osteoporosis: a nested case-control study using a national sample cohort
    Chanyang Min, Woo Jin Bang, Miyoung Kim, Dong Jun Oh, Hyo Geun Choi
    Archives of Osteoporosis.2019;[Epub]     CrossRef
  • Apolipoprotein E Genotype and Expression Correlated with Hepatitis C Virus Genotype and Infection
    Gyu-Nam Park, Hyun-Jung Jo, Hye-Ran Kim, Min-Ju Kim, Kyung-A Shin, Seung-Bok Hong, Kyung-Soo Chang
    Journal of Bacteriology and Virology.2019; 49(1): 27.     CrossRef
  • Incidence and Overall Survival of Biliary Tract Cancers in South Korea from 2006 to 2015: Using the National Health Information Database
    Byung-Woo Kim, Chang-Mo Oh, Hwa Young Choi, Joong-Won Park, Hyunsoon Cho, Moran Ki
    Gut and Liver.2019; 13(1): 104.     CrossRef
  • The change in the nationwide seroprevalence of hepatitis C virus and the status of linkage to care in South Korea from 2009 to 2015
    Eun Sun Jang, Moran Ki, Hwa Young Choi, Kyung-Ah Kim, Sook-Hyang Jeong
    Hepatology International.2019; 13(5): 599.     CrossRef
  • Analysis on Usefulness of Non-invasive Liver Fibrosis Evaluation Method according to the Liver Disease : Focused on H ep atitis C p atients
    Nam Ji-Hee, Kim Jung-Hoon
    Journal of Radiological Science and Technology.2019; 42(5): 345.     CrossRef
  • Cost-effectiveness of scaling up of hepatitis C screening and treatment: a modelling study in South Korea
    Jungyeon Kim, Markus Haacker, Salmaan Keshavjee, Rifat Atun
    BMJ Global Health.2019; 4(3): e001441.     CrossRef
  • Updates on Cancer Epidemiology in Korea, 2018
    Sun-Seog Kweon
    Chonnam Medical Journal.2018; 54(2): 90.     CrossRef
  • Factors influencing on health-related quality of life in South Korean with chronic liver disease
    Hyun Jin Kim, Hyeonsik Chu, Seonhye Lee
    Health and Quality of Life Outcomes.2018;[Epub]     CrossRef
  • Efficacy and safety of sofosbuvir plus ribavirin for Korean patients with hepatitis C virus genotype 2 infection: A retrospective multi-institutional study
    Young Min Kim, Suk Bae Kim, Il Han Song, Sae Hwan Lee, Hong Soo Kim, Tae Hee Lee, Young Woo Kang, Seok Hyun Kim, Byung Seok Lee, Hee Bok Chae, Myeong Jun Song, Ji Woong Jang, Soon Young Ko, Jae Dong Lee
    Clinical and Molecular Hepatology.2018; 24(3): 311.     CrossRef
  • Changes in Quality of Life of Chronic Hepatitis C Patients Participating in Clinical Trial
    Hoo-Jeung CHO, Euna PARK
    JOURNAL OF FISHRIES AND MARINE SCIENCES EDUCATION.2018; 30(5): 1725.     CrossRef
  • Estimation of Direct Medical Costs Related to Chronic Hepatitis C: A Rationale for Early Antiviral Therapy
    Do Young Kim
    Gut and Liver.2017; 11(6): 745.     CrossRef

Epidemiol Health : Epidemiology and Health
TOP