Epidemiology and Health

Original Article

Analysis of survival data in thalassemia patients in Shiraz, Iran: Abdolreza Rajaeefard, Mahmoud Hajipour, Hamid Reza Tabatabaee, Jafar Hassanzadeh, Shahab Rezaeian, Zahra Moradi, Mehdi Sharafi, Mohsen Shafiee, Ali Semati, Sanaz Safaei, Maryam Soltani; Epidemiol Health. 2015;37:e2015031. Published online July 7, 2015; DOI: https://doi.org/10.4178/epih/e2015031

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Abstract

OBJECTIVES
The survival rate of thalassemia patients has not been conclusively established, and the factors associated with survival remain unclear. This study aimed to determine the survival rate of thalassemia among patients in southern Iran and to identify the factors associated with mortality from thalassemia.

METHODS

This retrospective cohort study was conducted based on a retrospective review of the medical records of 911 beta-thalassemia patients in 2014. Data analysis was conducted using the Kaplan-Meier method and Cox regression analysis.

RESULTS

Overall, 212 patients (23.3%) died, and 26.8% had thalassemia intermedia. The 20-year, 40-year, and 60-year survival rates were 85%, 63%, and 54%, respectively. Both crude and adjusted analyses found that education, marital status, ferritin levels, and comorbidities were related to mortality.

CONCLUSIONS

Sociodemographic and hematological factors were found to be significantly associated with the survival rate of thalassemia. Addressing these factors may help healthcare providers and physicians to provide the best possible care and to improve the survival rate.

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