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- Effect of chemotherapy and radiotherapy on cognitive impairment in colorectal cancer: evidence from Korean National Health Insurance Database Cohort
- Kwanghyun Kim, Chang Woo Kim, Aesun Shin, Hyunseok Kang, Sun Jae Jung
- Epidemiol Health. 2021;43:e2021093. Published online November 2, 2021
- DOI: https://doi.org/10.4178/epih.e2021093
- 11,496 View
- 198 Download
- 6 Web of Science
- 7 Crossref
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Abstract
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AbstractOBJECTIVES
We investigated the risk of chemotherapy-related and radiotherapy-related cognitive impairment in colorectal cancer patients.METHODSMedical use data of colorectal cancer patients were obtained from the Korean National Health Insurance Database from 2004 to 2018. We randomly selected 40% of all colorectal cancer patients (n=148,848). Cognitive impairment was defined as having 1 or more International Classification of Diseases, 10th revision diagnostic codes for dementia or mild cognitive impairment. Patients aged 18 years or younger, patients diagnosed with cognitive impairment before colorectal cancer diagnosis (n=8,225), and patients who did not receive primary resection (n=45,320) were excluded. The effects of individual chemotherapy regimens on cognitive impairment were estimated. We additionally estimated the effect of radiotherapy in rectal cancer patients. Time-dependent competing risk Cox regression was conducted to estimate the overall and age-specific hazard ratios (HR) separately for colon and rectal cancer. Landmark analyses with different lag times were conducted as sensitivity analyses.RESULTSChemotherapy did not increase the risk of cognitive impairment in colorectal cancer patients (colon cancer: HR, 0.92; 95% confidence interval [CI], 0.83 to 1.03; rectal cancer: HR, 0.88; 95% CI, 0.75 to 1.04), while radiotherapy was negatively associated with cognitive impairment in rectal cancer patients (HR, 0.01; 95% CI, 0.84 to 0.99). Varying directions of the associations between regimens and cognitive impairment were detected. The adverse effect of certain chemotherapy regimens on cognition was more prominent in older adults.CONCLUSIONSChemotherapy and radiotherapy did not increase the risk of cognitive impairment. Older patients with low cognitive reserve could be affected by the adverse cognitive effects of chemotherapy. -
SummaryKorean summary
- 대장암 환자를 대상으로 한 항암화학요법 및 방사선요법은 인지기능저하의 위험을 높이지 않았다 - 일부 항암화학요법의 경우 고령의 대장암 환자에서 인지기능저하의 위험을 증가시킬 수 있다Key Message
Results from nationwide cohort of Korea showed that chemotherapy and radiotherapy did not increase the risk of cognitive impairment in colorectal cancer patients. -
Citations
Citations to this article as recorded by
- Research Progress: Exploring the Long-term Survival Status of Colorectal Cancer Survivors
Zhaobei Cai, Qianqian Chen, Enqiang Linghu
Clinical Cancer Investigation Journal.2024; 13(2): 34. CrossRef - Real-World Data-Derived Pharmacovigilance on Drug-Induced Cognitive Impairment Utilizing a Nationwide Spontaneous Adverse Reporting System
Yongjun Sunwoo, Sae Hyun Eom, Ji Seong Yun, Yujin Kim, Jeongmin Lee, Soo Hyeon Lee, Sooyoung Shin, Yeo Jin Choi
Medicina.2024; 60(7): 1028. CrossRef - Resting-State Brain Function Alteration in Colorectal Cancer Patients
Yanan Xu, Zihan Ma, Jieyu Chen, Huiyan Zhang, Guo Shen, Gang Huang, Wenwen Zhang, Lianping Zhao
Journal of Integrative Neuroscience.2024;[Epub] CrossRef - Predictors of cognitive impairment in patients undergoing ileostomy for colorectal cancer: a retrospective analysis
Jing Xu, Yuelan Yang, Die Hu
PeerJ.2023; 11: e15405. CrossRef - Soluble HSPG and HS relaying neuroinflammation contribute to behavioral comorbidities associated with cancer located outside the central nervous system
Yue-peng Liu, Yan-jun Yang
Medical Hypotheses.2023; 177: 111113. CrossRef - Chemotherapy-induced functional brain abnormality in colorectal cancer patients: a resting‐state functional magnetic resonance imaging study
Siwen Liu, Yesong Guo, Jie Ni, Na Yin, Chenchen Li, Xuan Pan, Rong Ma, Jianzhong Wu, Shengwei Li, Xiaoyou Li
Frontiers in Oncology.2022;[Epub] CrossRef - Association between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants
He-Ying Hu, Ya-Ru Zhang, Qiaolifan Aerqin, Ya-Nan Ou, Zuo-Teng Wang, Wei Cheng, Jian-Feng Feng, Lan Tan, Jin-Tai Yu
Translational Psychiatry.2022;[Epub] CrossRef
- Research Progress: Exploring the Long-term Survival Status of Colorectal Cancer Survivors
- Androgen deprivation therapy is associated with decreased second primary lung cancer risk in the United States veterans with prostate cancer
- Kyungsuk Jung, Jong Chul Park, Hyunseok Kang, Johann Christoph Brandes
- Epidemiol Health. 2018;40:e2018040. Published online August 11, 2018
- DOI: https://doi.org/10.4178/epih.e2018040
- 14,650 View
- 208 Download
- 7 Web of Science
- 6 Crossref
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Abstract
Summary
PDFSupplementary Material
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AbstractOBJECTIVES
We investigated whether androgen deprivation therapy (ADT) in prostate cancer patients was associated with a decreased risk for second primary lung cancer in US veterans.METHODSProstate cancer diagnoses in the US Veterans Affairs Cancer Registry between 1999 and 2008 were identified. Use of hormonal therapy and diagnoses of second primary lung cancer were determined from the registry. Synchronous prostate and lung cancers, defined as 2 diagnoses made within 1 year, were excluded from the analysis. Cancer-free survival was estimated using the Kaplan-Meier method and hazard ratios were estimated using Cox proportional hazard models.RESULTSAmong the 63,141 identified patients with prostate cancer, 18,707 subjects were eligible for the study. Hormonal therapy was used in 38% of patients and the median follow-up period was 28 months. ADT use was associated with longer lung cancer-free survival in prostate cancer patients (log-rank p=0.01). After adjusting for age, race, smoking and prostate cancer stage, ADT use was associated with decreased lung cancer risk by 15, 21, and 24% after 1, 2, and 3 years, respectively.CONCLUSIONSADT in prostate cancer patients may be associated with decreased second primary lung cancer risk among US veterans. -
SummaryKorean summary
비소세포성 폐암이 호르몬 수용체에 의해 영향을 받을 수 있다는 기존의 연구 결과를 바탕으로, 이 연구는 미국 재향 군인 병원 암등록 자료를 분석하여 전립선암 환자 중, 안드로겐 박탈 요법으로 치료를 받은 경우와 그렇지 않은 경우의 비소세포성 폐암 발생율을 비교분석하였다. 분석 결과, 전립선암을 진단받은 미국 재향군인들 중 안드로겐 박탈 요법으로 치료를 받은 환자들이 그렇지 않은 환자들에 비해 비소세포성 폐암 발생율이 통계적으로 유의미하게 감소하는 것이 관찰되었다. -
Citations
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International Journal of Cancer.2022; 151(5): 699. CrossRef - Racial and ethnic differences in risk of second primary cancers among prostate cancer survivors
Diana R. Withrow, Sara J. Schonfeld, Rochelle E. Curtis, Lindsay M. Morton, Michael B. Cook, Eboneé N. Butler, Amy Berrington de González
Cancer Causes & Control.2020; 31(11): 1011. CrossRef - Sex steroid metabolism and actions in non-small cell lung carcinoma
Teeranut Asavasupreechar, Monica S.M. Chan, Ryoko Saito, Yasuhiro Miki, Viroj Boonyaratanakornkit, Hironobu Sasano
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- Correlation between second and first primary cancer: systematic review and meta-analysis of 9 million cancer patients
- Green Tea Consumption and Stomach Cancer Risk: A Meta-Analysis
- Hyunseok Kang, Sun Young Rha, Kyung Won Oh, Chung Mo Nam
- Epidemiol Health. 2010;32:e2010001. Published online April 26, 2010
- DOI: https://doi.org/10.4178/epih/e2010001
- 20,928 View
- 130 Download
- 30 Crossref
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Abstract
PDF
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Abstract<sec><title>OBJECTIVES</title><p>Green tea has been suggested to have a chemopreventive effect against various cancers including stomach cancer. The aim of this study is to elucidate the relationship between green tea consumption and stomach cancer risk by meta-analysis.</p></sec><sec><title>METHODS</title><p>Eighteen observational studies were identified using MEDLINE, THE COCHRANE LIBRARY, RISS, and a manual search. Summary relative risks/odds ratios (RR/ORs) for the highest versus non/lowest green tea consumption levels were calculated on the basis of fixed and random effect models. Subgroup analyses were used to examine heterogeneity across the studies.</p></sec><sec><title>RESULTS</title><p>The combined results indicate a reduced risk of stomach cancer with intake of green tea (RR/OR=0.86, 95% CI=0.74-1.00). Subgroup analysis with six studies that reported differences between the highest and lowest consumption levels equal to or greater than five cups/day revealed a statistically significant protective effect (RR/OR=0.68, 95% CI=0.53-0.87).</p></sec><sec><title>CONCLUSION</title><p>Green tea appears to play a protective role against the development of stomach cancer. The results also suggest that a higher level of green tea consumption might be needed for a clear preventive effect to appear. This conclusion, however, should be interpreted with caution because various biases can affect the results of a meta-analysis.</p></sec>
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Citations
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