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2 "Hyungjun Kim"
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Original Article
The association between the consumption of raw Kudoa septempunctata–infected farmed Paralichthys olivaceus and gastrointestinal symptoms
Jihye An, En-Joo Jung, Soon-Ok Lee, Jong-Hoon Choi, JungHee Kim, Sung-Jong Hong, Sung-Hee Hong, Jung-Won Ju, Hyungjun Kim, Kwang-Pil Ko
Epidemiol Health. 2026;48:e2026003.   Published online January 19, 2026
DOI: https://doi.org/10.4178/epih.e2026003
  • 3,306 View
  • 103 Download
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
<i>Kudoa septempunctata</i> has been identified as the causative agent of food poisoning following the consumption of raw farmed <i>Paralichthys olivaceus</i>. However, cohort studies providing robust evidence for an association between <i>K. septempunctata</i> and gastrointestinal symptoms remain limited. This prospective cohort study investigated the association between the consumption of <i>K. septempunctata</i>–infected farmed <i>P. olivaceus</i> and the occurrence of gastrointestinal symptoms.
METHODS
Individuals who purchased raw farmed <i>P. olivaceus</i> between 2020 and 2021 were selected as the study population. Study data included 2 rounds of questionnaire surveys administered before and after consumption, 2 muscle specimens obtained from each purchased fish, and human biological specimens collected from individuals who developed gastrointestinal symptoms within 24 hours after consumption. Data were analyzed using the chi-square test and t-test, and the association between consumption of <i>K. septempunctata</i>–infected farmed <i>P. olivaceus</i> and gastrointestinal symptoms was evaluated using relative risk estimates between exposure groups.
RESULTS
The relative risk of gastrointestinal symptoms associated with exposure to <i>K. septempunctata</i>–infected <i>P. olivaceus</i> ranged from 71.2 (95% confidence interval [CI], 27.0 to 178.6) to 124.5 (95% CI, 43.5 to 355.0) across the 2 case definitions. A strong and statistically significant association was observed between exposure to <i>K. septempunctata</i>–infected <i>P. olivaceus</i> and the development of acute gastrointestinal symptoms.
CONCLUSIONS
These findings indicate both an association and a causal relationship between consumption of <i>K. septempunctata</i>–infected farmed <i>P. olivaceus</i> and the onset of gastrointestinal symptoms.
Summary
Korean summary
본 연구는 Kudoa septempunctata에 감염된 광어회 섭취가 위장관 증상과 연관되며, 감염 강도와 섭취량에 따라 증상의 중증도가 증가한다는 전향적 근거를 제시한다. 이러한 결과는 역학적 공백을 보완하며, 감시체계 강화와 예방 중심의 정책 마련의 필요성을 강조한다.
Key Message
This study provides prospective evidence that consumption of raw halibut infected with Kudoa septempunctata is associated with gastrointestinal symptoms, with the severity of symptoms increasing with the intensity of infection and the amount consumed. These results address a gap in epidemiological knowledge and highlight the need for strengthened surveillance systems and prevention-focused policies.
COVID-19: Brief Communication
Self-reported adverse events after 2 doses of COVID-19 vaccine in Korea
Yunhyung Kwon, Insob Hwang, Mijeong Ko, Hyungjun Kim, Seontae Kim, Soon-Young Seo, Enhi Cho, Yeon-Kyeng Lee
Epidemiol Health. 2023;45:e2023006.   Published online December 26, 2022
DOI: https://doi.org/10.4178/epih.e2023006
  • 23,152 View
  • 181 Download
  • 2 Web of Science
  • 4 Crossref
AbstractAbstract AbstractSummary PDF
Abstract
OBJECTIVES
In Korea, a national coronavirus disease 2019 (COVID-19) vaccination program was implemented, including 4 vaccines against COVID-19. A text messaging-based survey, in addition to a passive adverse event reporting system, was launched to quickly report unusual symptoms post-vaccination. This study compared the frequency of adverse events after COVID-19 vaccination based on the vaccine type and the type of 2-dose regimen (homologous or heterologous).
METHODS
Self-reported adverse events were collected through a text-message survey for 7 days after each vaccination. This study included 50,950 vaccine recipients who responded to the survey at least once. Informed consent to receive surveys via text was obtained from the vaccine recipients on the date of first vaccination.
RESULTS
The recipients of mRNA vaccines reported local and systemic reactions 1.6 times to 2.8 times more frequently after dose 2 than after dose 1 (p<0.001), whereas ChAdOx1-S recipients reported significantly fewer local and systemic reactions after dose 2 than after dose 1 (p<0.001). Local and systemic reactions were approximately 2 times and 4 times more frequent for heterologous vaccination than for BNT162b2/BNT162b2 and ChAdOx1-S/ChAdOx1-S regimens, respectively. Young individuals, female, and those receiving heterologous vaccine regimens including ChAdOx1-S/BNT162b2 vaccines reported more adverse events than older participants, male, and those with homologous vaccine regimens.
CONCLUSIONS
Although a heterologous regimen, youth, and female sex were associated with a higher risk of adverse reactions after COVID-19 vaccination, no critical issues were noted. Active consideration of heterologous schedules based on the evidence of efficacy and safety appears desirable.
Summary
Korean summary
본 연구는 코로나19 백신 접종 후 7일 동안 문자 설문조사를 통해 50,950명이 자가 보고한 이상반응자료를 분석하였다. mRNA 백신 접종자는1회 접종 후보다 2회 접종 후 국소 이상반응 및 전신이상반응을 1.6~2.8배 더 자주 보고한 반면, ChAdOx1-S 백신 접종자는1회 접종 후 보다 2회 접종 후 이상반응을 더 적게 보고하였다. 동종 백신접종 보다 교차 접종의 경우 2-4배 더 많은 이상반응을 보고 하였다. COVID-19 백신 접종 후 교차접종, 젊은 연령, 여성의 경우 좀 더 많은 이상반응을 보고하였지만,중대한 문제는 보고되지 않았다.
Key Message
Self-reported adverse events were collected through a text-message survey from 50,950 recipients for 7 days after COVID-19 vaccination. The mRNA vaccine recipients reported local and systemic reactions 1.6 to 2.8 times more frequently after dose 2 than after dose 1, whereas ChAdOx1-S recipients reported significantly fewer local and systemic reactions after dose 2 than after dose 1. Local and systemic reactions were approximately 2 to 4 times more frequent for heterologous vaccination than for homologous regimens. Although a heterologous regimen, youth, and female were associated with a higher risk of adverse reac¬tions after COVID-19 vaccination, no critical issues were noted.

Citations

Citations to this article as recorded by  
  • Retinal Vascular Occlusions After COVID-19 Vaccination in South Korea: A Nation-Wide Population-Based Study
    Yeji Kim, Kyungdo Han, Jae Hui Kim
    Ophthalmic Epidemiology.2025; 32(4): 403.     CrossRef
  • Safety of a second homologous Ad26.COV2.S vaccine among healthcare workers in the phase 3b implementation Sisonke study in South Africa
    Azwidihwi Takalani, Michelle Robinson, Phumeza Jonas, Annie Bodenstein, Vuyelo Sambo, Barry Jacobson, Vernon Louw, Jessica Opie, Jonny Peter, Pradeep Rowji, Ishen Seocharan, Tarylee Reddy, Nonhlanhla Yende-Zuma, Kentse Khutho, Ian Sanne, Linda-Gail Bekker
    Vaccine.2024; 42(6): 1195.     CrossRef
  • Comparative safety of monovalent and bivalent mRNA COVID-19 booster vaccines in adolescents aged 12 to 17 years in the Republic of Korea
    Mijeong Ko, Seontae Kim, Seok-Kyoung Choi, Seung Hwan Shin, Yeon-Kyeng Lee, Yunhyung Kwon
    Osong Public Health and Research Perspectives.2024; 15(4): 364.     CrossRef
  • A Nationwide Survey of mRNA COVID-19 Vaccinee’s Experiences on Adverse Events and Its Associated Factors
    Dongwon Yoon, Ha-Lim Jeon, Yunha Noh, Young June Choe, Seung-Ah Choe, Jaehun Jung, Ju-Young Shin
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
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