KSE
Search
- Page Path
- HOME > Search
Original Article
- Effect of chemotherapy and radiotherapy on cognitive impairment in colorectal cancer: evidence from Korean National Health Insurance Database Cohort
- Kwanghyun Kim, Chang Woo Kim, Aesun Shin, Hyunseok Kang, Sun Jae Jung
- Epidemiol Health. 2021;43:e2021093. Published online November 2, 2021
- DOI: https://doi.org/10.4178/epih.e2021093
- 28,395 View
- 225 Download
- 12 Web of Science
- 14 Crossref
-
Abstract
Summary
PDF
Supplementary Material -
AbstractOBJECTIVES
We investigated the risk of chemotherapy-related and radiotherapy-related cognitive impairment in colorectal cancer patients.METHODSMedical use data of colorectal cancer patients were obtained from the Korean National Health Insurance Database from 2004 to 2018. We randomly selected 40% of all colorectal cancer patients (n=148,848). Cognitive impairment was defined as having 1 or more International Classification of Diseases, 10th revision diagnostic codes for dementia or mild cognitive impairment. Patients aged 18 years or younger, patients diagnosed with cognitive impairment before colorectal cancer diagnosis (n=8,225), and patients who did not receive primary resection (n=45,320) were excluded. The effects of individual chemotherapy regimens on cognitive impairment were estimated. We additionally estimated the effect of radiotherapy in rectal cancer patients. Time-dependent competing risk Cox regression was conducted to estimate the overall and age-specific hazard ratios (HR) separately for colon and rectal cancer. Landmark analyses with different lag times were conducted as sensitivity analyses.RESULTSChemotherapy did not increase the risk of cognitive impairment in colorectal cancer patients (colon cancer: HR, 0.92; 95% confidence interval [CI], 0.83 to 1.03; rectal cancer: HR, 0.88; 95% CI, 0.75 to 1.04), while radiotherapy was negatively associated with cognitive impairment in rectal cancer patients (HR, 0.01; 95% CI, 0.84 to 0.99). Varying directions of the associations between regimens and cognitive impairment were detected. The adverse effect of certain chemotherapy regimens on cognition was more prominent in older adults.CONCLUSIONSChemotherapy and radiotherapy did not increase the risk of cognitive impairment. Older patients with low cognitive reserve could be affected by the adverse cognitive effects of chemotherapy. -
SummaryKorean summary
- 대장암 환자를 대상으로 한 항암화학요법 및 방사선요법은 인지기능저하의 위험을 높이지 않았다 - 일부 항암화학요법의 경우 고령의 대장암 환자에서 인지기능저하의 위험을 증가시킬 수 있다Key Message
Results from nationwide cohort of Korea showed that chemotherapy and radiotherapy did not increase the risk of cognitive impairment in colorectal cancer patients. -
Citations
Citations to this article as recorded by
- C5aR1 and cGAS/STING and their possible involvement in radiosensitivity of colorectal cancer
Quoc Thao Trang Pham, Pei-Ju Lee, Nguyen Quoc Khanh Le
iScience.2026; 29(3): 115009. CrossRef - Cognitive impairment risk in patients with rheumatoid arthritis: a population-based cohort study
Oh Chan Kwon, Hye Sun Lee, Hye Jin Yang, Wonhee Baek
RMD Open.2026; 12(2): e006685. CrossRef - Cancer-Related Cognitive Impairment in Breast Cancer: Current State of Knowledge, Mechanisms, Diagnosis, Prevention and Treatment
Federica Andreis, Chiara Deori, Valentina Giubileo, Chiara Abeni, Irene Caramella, Sara Cherri, Brunella Di Biasi, Michela Libertini, Silvia Noventa, Chiara Ogliosi, Ester Oneda, Tiziana Prochilo, Fausto Angelo Meriggi, Alberto Zaniboni
Cancers.2026; 18(12): 1974. CrossRef - Effect of chemotherapy on cognition and depression among solid tumor cancer patients in a tertiary care hospital
Jenanee Velayutham, Jayasutha Jayram, A. Vengadeswaran, S. Sivasupriya, K. Malini Prithiva Kumari, N. Arunagiri, Charupriya, Lisiya, Lourdu Akshaya, Sindhu Selvam, Ravichandran A. Selvam
International Journal of Basic & Clinical Pharmacology.2026; 15(5): 937. CrossRef - Epigenetic Regulation of Nuclear Factor Erythroid-2-Related Factor 2 in Colorectal Cancer Cells Resistant to Ionizing Radiation
Kyoung Ah Kang, Jinny Park, Mei Jing Piao, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Herath Mudiyanselage Maheshika Madhuwanthi Senavirathna, Jung-Hwan Kim, Suk Ju Cho, Jin Won Hyun
Biomolecules & Therapeutics.2025; 33(1): 182. CrossRef - Long-Term Survival Outcomes of Colorectal Cancer Survivors: An In-Depth Exploration
Zhaobei Cai, Qianqian Chen, Enqiang Linghu
Asian journal of Current Research in Clinical Cancer.2025; 5(1): 12. CrossRef - S100A11 mediates the protective effects of edaravone dexborneol on docetaxel-induced cognitive impairment in rats by inhibiting the MAPK signaling pathway
Ping Liu, Jiantao Jia, Yinliang Lu, Hanmin Tang, Chengyi Gao, Suxia Han
Toxicology and Applied Pharmacology.2025; 504: 117504. CrossRef - Research Progress: Exploring the Long-term Survival Status of Colorectal Cancer Survivors
Zhaobei Cai, Qianqian Chen, Enqiang Linghu
Clinical Cancer Investigation Journal.2024; 13(2): 34. CrossRef - Real-World Data-Derived Pharmacovigilance on Drug-Induced Cognitive Impairment Utilizing a Nationwide Spontaneous Adverse Reporting System
Yongjun Sunwoo, Sae Hyun Eom, Ji Seong Yun, Yujin Kim, Jeongmin Lee, Soo Hyeon Lee, Sooyoung Shin, Yeo Jin Choi
Medicina.2024; 60(7): 1028. CrossRef - Resting-State Brain Function Alteration in Colorectal Cancer Patients
Yanan Xu, Zihan Ma, Jieyu Chen, Huiyan Zhang, Guo Shen, Gang Huang, Wenwen Zhang, Lianping Zhao
Journal of Integrative Neuroscience.2024;[Epub] CrossRef - Predictors of cognitive impairment in patients undergoing ileostomy for colorectal cancer: a retrospective analysis
Jing Xu, Yuelan Yang, Die Hu
PeerJ.2023; 11: e15405. CrossRef - Soluble HSPG and HS relaying neuroinflammation contribute to behavioral comorbidities associated with cancer located outside the central nervous system
Yue-peng Liu, Yan-jun Yang
Medical Hypotheses.2023; 177: 111113. CrossRef - Chemotherapy-induced functional brain abnormality in colorectal cancer patients: a resting‐state functional magnetic resonance imaging study
Siwen Liu, Yesong Guo, Jie Ni, Na Yin, Chenchen Li, Xuan Pan, Rong Ma, Jianzhong Wu, Shengwei Li, Xiaoyou Li
Frontiers in Oncology.2022;[Epub] CrossRef - Association between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants
He-Ying Hu, Ya-Ru Zhang, Qiaolifan Aerqin, Ya-Nan Ou, Zuo-Teng Wang, Wei Cheng, Jian-Feng Feng, Lan Tan, Jin-Tai Yu
Translational Psychiatry.2022;[Epub] CrossRef
- C5aR1 and cGAS/STING and their possible involvement in radiosensitivity of colorectal cancer
First
Prev
