Epidemiology and Health

Systematic Review

Association between gallstones and the risk of biliary tract cancer: a systematic review and meta-analysis: Dan Huang, Hyundeok Joo, Nan Song, Sooyoung Cho, Woosung Kim, Aesun Shin; Epidemiol Health. 2021;43:e2021011. Published online February 3, 2021; DOI: https://doi.org/10.4178/epih.e2021011

15,060 View
397 Download
16 Web of Science
16 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
Biliary tract cancers (BTCs) are rare but highly fatal. Although the etiology of BTC is poorly understood, gallstones are proposed to be a major risk factor. We conducted a systematic review and meta-analysis to examine the associations between gallstone characteristics and BTC risk.

METHODS

We searched the MEDLINE, Embase, and Cochrane Central databases and systematically reviewed cohort and case-control studies published before April 9, 2018. All the included studies reported appropriate risk estimates and confidence intervals (CIs) for associations between the presence, size, number, or duration of gallstones and the risk of BTC, including gallbladder cancer (GBC), extrahepatic bile duct cancer (EBDC), and ampulla of Vater cancer (AOVC). Summary odds ratios (ORs) and their 95% CIs were calculated using a random-effects model in the meta-analysis. Subgroup analyses were conducted to inspect sources of potential heterogeneity, and the Egger test was performed to assess publication bias.

RESULTS

Seven cohort studies and 23 case-control studies in Asian, European, and American populations were included. The presence of gallstones was associated with an increased risk of BTC (OR, 4.38; 95% CI, 3.23 to 5.93; I2=91.2%), GBC (OR, 7.26; 95% CI, 4.33 to 12.18), EBDC (OR, 3.17; 95% CI, 2.24 to 4.50), and AOVC (OR, 3.28; 95% CI, 1.33 to 8.11). Gallstone size (>1 vs. <1 cm; OR, 1.88; 95% CI, 1.10 to 3.22) was significantly associated with the risk of GBC.

CONCLUSIONS

Gallstone characteristics, such as presence, size, and number, are associated with an increased risk of BTC. However, significantly high heterogeneity in the meta-analyses is a limitation of this study.

Summary

Korean summary
The prevalence of APCT-detected sacroiliitis in CD patients was higher than that in controls, but the condition was asymptomatic. The clinical significance of asymptomatic sacroiliitis in Korean CD patients remains unclear.

Key Message
본 연구에서는 체계적 문헌고찰과 메타분석법을 활용하여 여러 선행연구에서 담도계암 전반과 담석의 다양한 특성사이에 연관성이 있는지 탐구하였다. 총 30개의 문헌을 분석한 결과 담석의 존재 여부가 담도계암과 각 하위 암의 위험을 모두 높이는 것으로 나타났고, 담석의 크기가 클수록 담낭암의 위험이 높은 것으로 드러났다. 본 연구는 담석과 담도계암 전반의 연관성에 대해 체계적으로 정리한 최초의 문헌으로서 담석과 담도계암의 관계에 대한 이해의 폭을 넓히고, 추후 해당 주제로 추가 연구를 수행하는 데에 있어 기준점이 될 수 있으리라 기대한다.

Citations

Citations to this article as recorded by

The Global Burden of Early-Onset Biliary Tract Cancer: Insight From the Global Burden of Disease Study 2019
Pojsakorn Danpanichkul, Cheng H. Ng, Darren J.H. Tan, Mark D. Muthiah, Siwanart Kongarin, Karan Srisurapanont, Yatawee Kanjanakot, Kwanjit Duangsonk, Daniel Q. Huang, Hiroyuki Suzuki, Denise M. Harnois, Ju D. Yang, Mazen Noureddin, Karn Wijarnpreecha
Journal of Clinical and Experimental Hepatology.2024; 14(2): 101320. CrossRef
Tauroursodeoxycholic acid suppresses biliary epithelial cell apoptosis and endoplasmic reticulum stress by miR-107/NCK1 axis in a FXR-dependent manner
Debiao Pan, Jun Wang, Hailin Ye, Yong Qin, Shengqian Xu, Guanxiong Ye, Hejuan Shen
Drug and Chemical Toxicology.2024; : 1. CrossRef
Incidental findings of gallbladder and bile ducts – Management strategies: Normal findings, anomalies, “silent gallstones” and bile duct dilatation - A World Federation of Ultrasound in Medicine and Biology (WFUMB) position paper
Christian Jenssen, Christian P. Nolsøe, Torben Lorentzen, Jae Young Lee, Nitin Chaubal, Kathleen Möller, Caroline Ewertsen, Xin Wu Cui, Edda Leonor Chaves, Alina Popescu, Yi Dong, Christoph F. Dietrich
WFUMB Ultrasound Open.2024; 2(1): 100034. CrossRef
Integrated study reveals mechanism of Tripterygium Wilfordii against cholangiocarcinoma based on bioinformatics approaches and molecular dynamics simulation
Yuting Zhao, Junfeng Guo
Computational Biology and Chemistry.2024; 109: 108030. CrossRef
Habitually Skipping Breakfast Is Associated with the Risk of Gastrointestinal Cancers: Evidence from the Kailuan Cohort Study
Tong Liu, Yiming Wang, Xiaomeng Wang, Chenan Liu, Qi Zhang, Mengmeng Song, Chunhua Song, Qingsong Zhang, Hanping Shi
Journal of General Internal Medicine.2023; 38(11): 2527. CrossRef
Rapid detection of serological biomarkers in gallbladder carcinoma using fourier transform infrared spectroscopy combined with machine learning
Jingrui Dou, Wubulitalifu Dawuti, Jintian Li, Hui Zhao, Run Zhou, Jing Zhou, Renyong Lin, Guodong Lü
Talanta.2023; 259: 124457. CrossRef
Gallbladder Clear Cell Carcinoma: Report of a Rare Case and Literature Review
Panayiotis Papatheodorou, Kyriakos Frantzeskou, Kyriaki Konstantinou, Elena Theophanous, Eric Bergeron
Case Reports in Surgery.2023; 2023: 1. CrossRef
Mediterranean diet and olive oil, microbiota, and obesity-related cancers. From mechanisms to prevention
Enrique Almanza-Aguilera, Ainara Cano, Mercedes Gil-Lespinard, Nerea Burguera, Raul Zamora-Ros, Antonio Agudo, Marta Farràs
Seminars in Cancer Biology.2023; 95: 103. CrossRef
Independent of Primary Sclerosing Cholangitis and Cirrhosis, Early Adulthood Obesity Is Associated with Cholangiocarcinoma
Rikita I. Hatia, Madhulika Eluri, Ernest T. Hawk, Akram Shalaby, Elif Karatas, Ahmed Shalaby, Ahmed Abdelhakeem, Reham Abdel-Wahab, Ping Chang, Asif Rashid, Prasun K. Jalal, Christopher I. Amos, Younghun Han, Tannaz Armaghany, Rachna T. Shroff, Donghui Li
Cancer Epidemiology, Biomarkers & Prevention.2023; 32(10): 1338. CrossRef
Cholecystectomy reduces the risk of cholangiocarcinoma in patients with complicated gallstones, but has negligible effect on hepatocellular carcinoma
Hyeong Sik Ahn, Hyun Jung Kim, Tae Uk Kang, Seon Mee Park
Journal of Gastroenterology and Hepatology.2022; 37(4): 669. CrossRef
Primary spindle cell sarcoma of gallbladder
Xin Long, Yan Chen, Wei-Xun Chen, Yu Wu, Jia Song, Jin Chen, Lei Zhang
Medicine.2022; 101(2): e28549. CrossRef
Circulating miRNA and cell-free DNA as a potential diagnostic tool in early detection of biliary tract cancer: a meta-analysis
Aakansha Singh, Anjana Dwivedi
Biomarkers.2022; 27(5): 399. CrossRef
Immunogenetic clustering of 30 cancers
Lisa M. James, Apostolos P. Georgopoulos
Scientific Reports.2022;[Epub] CrossRef
Risk factors for the occurrence of ampullary tumors: A case‐control study
Piera Zaccari, Livia Archibugi, Giulio Belfiori, Enrico Nista, Giuseppe dell'Anna, Stefano Crippa, Tommaso Schepis, Matteo Tacelli, Francesca Aleotti, Maria Chiara Petrone, Alberto Mariani, Guido Costamagna, Antonio Gasbarrini, Alberto Larghi, Massimo Fal
United European Gastroenterology Journal.2022; 10(7): 730. CrossRef
Evolving Paradigms in the Systemic Treatment of Advanced Gallbladder Cancer: Updates in Year 2022
Zishuo Ian Hu, Kian-Huat Lim
Cancers.2022; 14(5): 1249. CrossRef
Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease
Tianhao Zhou, Debjyoti Kundu, Jonathan Robles-Linares, Vik Meadows, Keisaku Sato, Leonardo Baiocchi, Burcin Ekser, Shannon Glaser, Gianfranco Alpini, Heather Francis, Lindsey Kennedy
Cells.2021; 10(8): 2072. CrossRef

Original Articles

Human papillomavirus: footprints in the population of western India: Ashi Robert Thobias, Kinjal Ankit Patel, Supreet Dhananjay Bhatt, Kruti Ashvinkumar Mehta, Chetana Deepal Parekh, Pariseema Sharad Dave, Prabhudas Shankarbhai Patel; Epidemiol Health. 2021;43:e2021013. Published online February 3, 2021; DOI: https://doi.org/10.4178/epih.e2021013

9,779 View
322 Download
2 Web of Science

Abstract Summary PDF: Abstract
OBJECTIVES
Cancer is a multi-factorial disease, with various intrinsic and environmental factors contributing to its occurrence. Human papillomavirus (HPV) has been associated with the occurrence of many cancers. India severely suffers from 3 HPV-associated cancers (cervical cancer, oral cancer, and oropharyngeal cancer). Hence, the present study aimed to evaluate the HPV burden in these 3 cancers among patients from the western region of India.
METHODS
DNA was isolated from samples from 400 cervical cancer, 127 oral cancer, and 75 oropharyngeal cancer patients. Polymerase chain reaction was performed using degenerate primers for HPV infection.
RESULTS
Overall, HPV infection was observed in 87% of cervical cancer cases, 12.5% of oral cancer cases, and 26.7% of oropharyngeal cancer cases when analyzed with a cumulative detection method using the MY 09/11, GP 5+/6+, and CP I/II primer sets.
CONCLUSIONS
A significant prevalence of HPV infection was detected in all 3 cancers using the degenerate primer sets. This finding implies that testing for HPV infection using multiple primer sets is crucial for determining its actual prevalence in various malignancies.; Summary

Key Message
The study emphasised the need to screen population of India for HPV infection for better prognosis and disease management and showcases a perfect screening module to efficiently screen the HPV strains.

Inherently high uncertainty in predicting the time evolution of epidemics: Seung-Nam Park, Hyong-Ha Kim, Kyoung Beom Lee; Epidemiol Health. 2021;43:e2021014. Published online February 8, 2021; DOI: https://doi.org/10.4178/epih.e2021014

11,152 View
306 Download
2 Web of Science
2 Crossref

Abstract Summary PDF

Abstract

OBJECTIVES
Amid the spread of coronavirus disease 2019 (COVID-19), with its high infectivity, we have relied on mathematical models to predict the temporal evolution of the disease. This paper aims to show that, due to active behavioral changes of individuals and the inherent nature of infectious diseases, it is complicated and challenging to predict the temporal evolution of epidemics.

METHODS

A modified susceptible-exposed-infectious-hospitalized-removed (SEIHR) compartment model with a discrete feedback-controlled transmission rate was proposed to incorporate individuals’ behavioral changes into the model. To figure out relative uncertainties in the infection peak time and the fraction of the infected population at the peak, a deterministic method and 2 stochastic methods were applied.

RESULTS

A relatively small behavioral change of individuals with a feedback constant of 0.02 in the modified SEIHR model resulted in a peak time delay of up to 50% using the deterministic method. Incorporating stochastic methods into the modified model with a feedback constant of 0.04 suggested that the relative random uncertainty of the maximum fraction of infections and that of the peak time for a population of 1 million reached 29% and 9%, respectively. Even without feedback, the relative uncertainty of the peak time increased by up to 20% for a population of 100,000.

CONCLUSIONS

It is shown that uncertainty originates from stochastic properties of infections. Without a proper selection of the evolution scenario, active behavioral changes of individuals could serve as an additional source of uncertainty.

Summary

Korean summary
이 논문은 감염병에 대응하는 개인의 능동적 행동 변화와 감염병의 고유한 특성 때문에 그 진행을 예측하는 것은 복잡하고 도전적인 작업이라는 것을 보이기 위한 것이다. 이런 행동 변화를 고려하기 위하여 감염률에 피드백 제어를 줄 수 있는 SEIHR 수정 모델을 제안하였다. 최대 감염까지 경과 시간과 최대 감염률의 상대 불확도를 계산하기 위하여 하나의 결정론적 방법과 두 가지의 확률론적 방법 적용하였다. 감염병 예측의 불확도는 감염의 확률론적 성질에 기인하는 것을 알 수 있었다. 적절한 진행의 시나리오를 설정하지 못할 경우 개인의 능동적 행동 변화가 추가적인 불확도 요인이 될 것이다.

Key Message
This paper is to show that, due to active behavioral changes of individuals and inherent natures of infectious diseases, it is complicated and challenging to predict the temporal evolutions. A modified-SEIHR compartment model with a discretely feedback-controlled transmission rate was proposed to incorporate the behavioral changes of individuals into the model. To figure out relative uncertainties in the infection peak times and the fraction of the infected population at the peak, a deterministic method and two stochastic methods were applied. It is shown that the uncertainty of the prediction originates from stochastic properties of the infections. Without a proper selection of the evolution scenarios, the active behavioral changes of individuals could cause an additional uncertainty.

Citations

Citations to this article as recorded by

Modeling Supply and Demand Dynamics of Vaccines against Epidemic-Prone Pathogens: Case Study of Ebola Virus Disease
Donovan Guttieres, Charlot Diepvens, Catherine Decouttere, Nico Vandaele
Vaccines.2023; 12(1): 24. CrossRef
Evolution and consequences of individual responses during the COVID-19 outbreak
Wasim Abbas, Masud M. A., Anna Park, Sajida Parveen, Sangil Kim, Siew Ann Cheong
PLOS ONE.2022; 17(9): e0273964. CrossRef

Data Profile

Establishment of the Korea National Health and Nutrition Examination Survey air pollution study dataset for the researchers on the health impact of ambient air pollution: Myung-Jae Hwang, Jisun Sung, Miryoung Yoon, Jong-Hun Kim, Hui-Young Yun, Dae-Ryun Choi, Youn-Seo Koo, Kyungwon Oh, Sungha Yun, Hae-Kwan Cheong; Epidemiol Health. 2021;43:e2021015. Published online February 8, 2021; DOI: https://doi.org/10.4178/epih.e2021015

14,191 View
392 Download
4 Web of Science
4 Crossref

Abstract Summary PDF Supplementary Material

Abstract

To provide a nationwide representative dataset for the study on health impact of air pollution, we combined the data from the Korea National Health and Nutrition Examination Survey with the daily air quality and weather data by matching the date of examination and the residential address of the participants. The database of meteorological factors and air quality as sources of exposure data were estimated using the Community Multiscale Air Quality model. The linkage dataset was merged by three ways; administrative district, si-gun-gu (city, county, and district), and geocode (in latitude and longitude coordinate units) based on the participants’ residential address, respectively. During the study period, the exposure dataset of 85,018 individuals (38,306 men and 46,712 women) whose examination dates were recorded were obtained. According to the definition of exposure period, the dataset was combined with the data on short-term, mid-term, and long-term exposure to air pollutants and the meteorological indices. Calculation of the daily merged dataset’s average air pollution linked by si-gun-gu and geocode units showed similar results. This study generated a daily average of meteorological indices and air pollution exposure dataset for all regions including rural and remote areas in Korea for 11 years. It is expected to provide a platform for the researchers studying the health impact of air pollution and climate change on the representative population and area, which may facilitate the establishment of local health care plans by understanding the residents’ health status at the local as well as national level.

Summary

Korean summary
-2007년부터 2017년까지 11년간 국민건강영양조사의 검진조사 대상자의 검진일자와 지리정보를 기준으로 85,018명에 대해 기상 및 대기오염 모델링 자료를 결합하여 조사 대상자의 거주지주소를 이용하여 시·군·구 단위와 주소 기반 위경도 좌표를 기준으로 각각 노출자료를 결합함. -대기오염의 단기노출, 중기노출, 장기노출의 건강영향을 평가하기 위해 지연효과(lag effect)를 적용하여 각 건강자료와 결합함. -기상 및 대기오염 모델링 자료와 연계된 국민건강영양조사의 활용을 위한 data profile을 제시함.

Key Message
-We built a dataset for air pollution research by combining meteorological and air pollution modeling data through CMAQ for 85,018 individuals based on the date of examination and geographic information of the Korea National Health and Nutrition Examination Survey participants for 11 years, from 2007 to 2017. -Each exposure data was combined based on si-gun-gu (city, county, and district) and geocode (in latitude and longitude coordinate units) based on the participants’ residential address. -To evaluate the health effects of short-, medium- and long-term air pollution exposure, the lag values of days, months, and years was applied and combined with each health data. -A data profile was presented for the Korea National Health and Nutrition Examination Survey linked to meteorological and air pollution modeling data.

Citations

Citations to this article as recorded by

Association between ambient particulate matter levels and hypertension: results from the Korean Genome and Epidemiology Study
Sewhan Na, Jong-Tae Park, Seungbeom Kim, Jinwoo Han, Saemi Jung, Kyeongmin Kwak
Annals of Occupational and Environmental Medicine.2023;[Epub] CrossRef
Effect of Short- to Long-Term Exposure to Ambient Particulate Matter on Cognitive Function in a Cohort of Middle-Aged and Older Adults: KoGES
Jane J. Lee, Ji Hyun Kim, Dae Sub Song, Kyoungho Lee
International Journal of Environmental Research and Public Health.2022; 19(16): 9913. CrossRef
Long-Term Effects of Ambient Particulate and Gaseous Pollutants on Serum High-Sensitivity C-Reactive Protein Levels: A Cross-Sectional Study Using KoGES-HEXA Data
Ji Hyun Kim, Hae Dong Woo, Sunho Choi, Dae Sub Song, Jung Hyun Lee, Kyoungho Lee
International Journal of Environmental Research and Public Health.2022; 19(18): 11585. CrossRef
Effects of exposure to ambient air pollution on pulmonary function impairment in Korea: the 2007-2017 Korea National Health and Nutritional Examination Survey
Soo Beom Choi, Sungha Yun, Sun-Ja Kim, Yong Bum Park, Kyungwon Oh
Epidemiology and Health.2021; 43: e2021082. CrossRef

Cohort Profile

Cohort profile: the Ewha Birth and Growth Study: Hye Ah Lee, Bohyun Park, Jungwon Min, Eun Jeong Choi, Ui Jeong Kim, Hyun Jin Park, Eun Ae Park, Su Jin Cho, Hae Soon Kim, Hwayoung Lee, Young Ju Kim, Young Sun Hong, Eui-Jung Kim, Eun Hee Ha, Hyesook Park; Epidemiol Health. 2021;43:e2021016. Published online February 22, 2021; DOI: https://doi.org/10.4178/epih.e2021016

11,883 View
404 Download
8 Web of Science
9 Crossref

Abstract Summary PDF Supplementary Material

Abstract

With the introduction of life-course epidemiology, researchers realized the importance of identifying risk factors in early life to prevent chronic diseases. This led to the establishment of the Ewha Birth and Growth Study in 2001; the study is a prospective birth cohort designed to provide evidence of early life risk factors for a child’s growth and health. Participants were recruited from those who visited Ewha Womans University Mokdong Hospital (a tertiary hospital in southwest Seoul, Korea) for prenatal care at 24-28 weeks of gestation. In total, 891 mothers enrolled in this study between 2001 and 2006 and their offspring (n=940) were followed-up. Regular check-up examinations of offspring were conducted at 3 years, 5 years, and 7 years of age and every year thereafter. To consider age-related health issues, extensive data were collected using questionnaires and measurements. In 2021, the study subjects will reach 19 years of age, and we are planning a check-up examination for early adulthood. About 20 years have passed since the cohort data were collected, and we have published results on childhood health outcomes associated with prenatal and birth characteristics, genetic and epigenetic characteristics related to childhood metabolism, the effects of exposure to endocrine disruptors, and dietary patterns in childhood. Recently, we started reporting on topics related to adolescent health. The findings will facilitate identification of early life risk factors for chronic diseases and the development of interventions for diseases later in life.

Summary

Korean summary
이화영아성장코호트는 만성질환 예방을 위한 생애초기 위험인자에 대한 근거를 제공하기 위해 2001년에 시작되었습니다. 이화영아성장코호트는 국내에서 선도적인 장기 추적관찰 연구로, 소아기 건강과 관련된 산전 및 출생 시 특징, 소아기 대사와 관련된 유전적 혹은 후성학적 특성, 내분비 장애물질 노출에 따른 영향, 소아기의 식이패턴과 같은 다양한 연구결과들을 발표하였습니다. 추후 청년기의 자료 수집을 계획하고 있으며, 우리의 연구결과는 만성질환 예방을 위한 중재 개발에 기여할 것으로 기대됩니다.

Key Message
To provide evidence of early life risk factors for the prevention of chronic diseases, the Ewha Birth and Growth Study was started in 2001. The Ewha Birth and Growth cohort is a leading long-term follow-up study in Korea, and we have published results on childhood health outcomes associated with prenatal and birth characteristics, genetic and epigenetic characteristics related to childhood metabolism, the effects of exposure to endocrine disruptors, and dietary patterns in childhood. We are planning to collect data for early adulthood, and our findings will contribute to the development of interventions to prevent chronic diseases.

Citations

Citations to this article as recorded by

Prospective association between phthalate exposure in childhood and liver function in adolescence: the Ewha Birth and Growth Cohort Study
Seonhwa Lee, Hye Ah Lee, Bohyun Park, Hyejin Han, Young Sun Hong, Eun Hee Ha, Hyesook Park
Environmental Health.2023;[Epub] CrossRef
BMI trajectory and inflammatory effects on metabolic syndrome in adolescents
Ui-Jeong Kim, Eun Jeong Choi, Hyunjin Park, Hye Ah Lee, Bohyun Park, Jungwon Min, Eun Ae Park, Su Jin Cho, Hae Soon Kim, Hwayoung Lee, Young Ju Kim, Young Sun Hong, Eun Hee Ha, Seungyoun Jung, Hyesook Park
Pediatric Research.2023; 94(1): 153. CrossRef
The Effect of Childhood Obesity or Sarcopenic Obesity on Metabolic Syndrome Risk in Adolescence: The Ewha Birth and Growth Study
Hyunjin Park, Seunghee Jun, Hye-Ah Lee, Hae Soon Kim, Young Sun Hong, Hyesook Park
Metabolites.2023; 13(1): 133. CrossRef
Synergistic effect of serum uric acid and body mass index trajectories during middle to late childhood on elevation of liver enzymes in early adolescence: Findings from the Ewha Birth and Growth Study
Sung Hee Lee, Eun Jeong Choi, Ui Jeong Kim, Hyunjin Park, Bomi Park, Hye Ah Lee, Hyesook Park, Linglin Xie
PLOS ONE.2023; 18(4): e0282830. CrossRef
The association between urinary cotinine level and metabolic syndrome profiles among adolescents: findings from the Ewha Birth and growth study
Hyunjin Park, Ui-Jeong Kim, Eun Jeong Choi, Seunghee Jun, Bomi Park, Hye Ah Lee, Hae Soon Kim, Hyesook Park
BMC Public Health.2023;[Epub] CrossRef
The Mediating Effect of Inflammation between the Dietary and Health-Related Behaviors and Metabolic Syndrome in Adolescence
Ui-Jeong Kim, Eun-Jeong Choi, Hyunjin Park, Hye-Ah Lee, Bomi Park, Haesoon Kim, Youngsun Hong, Seungyoun Jung, Hyesook Park
Nutrients.2022; 14(11): 2339. CrossRef
Precision medicine via the integration of phenotype-genotype information in neonatal genome project
Xinran Dong, Tiantian Xiao, Bin Chen, Yulan Lu, Wenhao Zhou
Fundamental Research.2022; 2(6): 873. CrossRef
Association of participation in the Northern Finland Birth Cohort 1986 with mental disorders and suicidal behaviour
Martta Kerkelä, Mika Gissler, Juha Veijola
Epidemiology and Health.2022; 44: e2022005. CrossRef
Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence
Eun Jeong Choi, Hye Ah Lee, Bomi Park, Bohyun Park, Hae Soon Kim, Young Sun Hong, Hyesook Park
Scientific Reports.2021;[Epub] CrossRef

Original Articles

The effect of demographic characteristics on the relationship between smoking and dry mouth in Iran: a cross-sectional, case-control study: Shahla Kakoei, Amir Hossein Nekouei, Sina Kakooei, Hamid Najafipour; Epidemiol Health. 2021;43:e2021017. Published online February 28, 2021; DOI: https://doi.org/10.4178/epih.e2021017

11,123 View
350 Download
4 Web of Science
4 Crossref

Abstract Summary PDF

Abstract

OBJECTIVES
The effect of age, sex, and other demographic factors on the relationship between smoking and dry mouth remains unknown. The aim of this study was to investigate the effects of demographic characteristics on the relationship between dry mouth, also known as xerostomia, and smoking.

METHODS

This case-control study included 5,640 randomly-selected subjects from the second phase of the Kerman Coronary Artery Disease Risk Factors Study, which observed 10,000 participants from 2014 to 2018. A checklist was used to record the participants’ demographic characteristics and smoking frequency. Each participant completed a six-item Fox questionnaire to measure dry mouth as a dependent variable. The interaction terms of daily cigarette smoking with sex, age, educational level, and marital status were entered into the model. Non-significant terms were removed using hierarchical model selection.

RESULTS

Of the sample, 3,429 (60.8%) did not have dry mouth and were analyzed as controls, whereas 2,211 (39.2%) had xerostomia and were deemed to be cases. Smokers were more likely to have dry mouth in all ages and both sexes (p < 0.001). As male became older, the chance of having dry mouth increased more rapidly than among female smokers (p < 0.001). In addition, female smokers were more likely to have dry mouth than male smokers (p < 0.001).

CONCLUSIONS

The likelihood of dry mouth among daily smokers depended on age and sex. Female smokers were more likely to have dry mouth, and its likelihood increased with age in daily smokers of both sexes, though more rapidly in males.

Summary

Key Message
The relationship between dry mouth as a distressing condition and smoking has been confirmed by many studies, but so far the severity and weakness of this relationship have not been studied in terms of demographic variables. We showed that the female smokers were more likely to have dry mouth. The chance of having dry mouth increase in a male smoker more than a female smoker as age increases.

Citations

Citations to this article as recorded by

The prevalence of xerostomia among e-cigarette or combustible tobacco users: A systematic review and meta-analysis
Xingtong Guo, Lili Hou, Xuepei Peng, Fuyou Tang
Tobacco Induced Diseases.2023; 21(February): 1. CrossRef
World Workshop on Oral Medicine VIII: Development of a core outcome set for dry mouth: a systematic review of outcome domains for xerostomia
Paswach Wiriyakijja, Sven Eric Niklander, Alan Roger Santos-Silva, Michal Kuten Shorrer, Melanie Louise Simms, Alessandro Villa, Vidya Sankar, Alexander Ross Kerr, Richeal Ni Riordain, Siri Beier Jensen, Konstantina Delli
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2023; 135(6): 827. CrossRef
Xerostomia as a key predictor of physical frailty among community-dwelling older adults in Japan: a five-year prospective cohort study from The Otassha Study
Yuki Ohara, Masahori Iwasaki, Maki Shirobe, Hisashi Kawai, Ayako Edahiro, Keiko Motokawa, Yoshinori Fujiwara, Hunkyung Kim, Kazushige Ihara, Shuichi Obuchi, Yutaka Watanabe, Hirohiko Hirano
Archives of Gerontology and Geriatrics.2022; 99: 104608. CrossRef
Effect of vitamin E and supragingival scaling on salivary gland function in patients with differentiated thyroid cancer treated with 131I
Yan Cheng, Huimin Tong, Xiaoqian Li, Xiaomin Zhang, Ju Fang, Rongli Yue, Nan Huang, Jing Tian, Feiyan Yu, Ying Gao
Nuclear Medicine Communications.2022; 43(9): 995. CrossRef

Estimated incidence of juvenile-onset recurrent respiratory papillomatosis in Korea: Jin-Kyoung Oh, Hwa Young Choi, Minji Han, Yuh-Seog Jung, Sang Joon Lee, Moran Ki; Epidemiol Health. 2021;43:e2021019. Published online March 10, 2021; DOI: https://doi.org/10.4178/epih.e2021019

11,515 View
322 Download
1 Web of Science
1 Crossref

Abstract Summary PDF

Abstract

OBJECTIVES
Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 and 11 and is potentially preventable through vaccination. This study estimated the incidence of juvenile-onset RRP before the implementation of the national HPV vaccination program in Korea.

METHODS

We conducted a cohort study using claims data provided by a mandatory insurance program to estimate the incidence of RRP and associated healthcare use. Patients with juvenile RRP were defined as those aged ≤12 years with ≥2 admissions or ≥2 outpatient visits during which they received the International Classification of Diseases, 10th revision code for benign neoplasms of the larynx (D14.1).

RESULTS

During 2002-2014, 123 children (74 boys and 49 girls) were diagnosed with RRP. The patients had a mean of 6.5 person-years of follow-up. The incidence was estimated at 0.30/100,000 person-years. The median age at diagnosis was 4.0 years (mean, 4.3). Thirty-six (29.3%) patients underwent surgery, including 23 patients (18.7%) who underwent 2 or more surgical procedures. Severe disease, measured by more frequent surgical procedures and shorter time intervals between consecutive operations, was associated with a younger age at diagnosis.

CONCLUSIONS

The estimated incidence of juvenile-onset RRP in Korea was similar to that reported in other countries. The RRP burden should continue to be monitored using National Health Insurance Service claims data.

Summary

Korean summary
재발성호흡기유두종증은 사람유두종바이러스에 의해 발현되는 희귀 질환이다. 건강보험 청구자료를 활용하여 2002년 이후 출생아 전수 중 2014년까지 후두양성종양으로 2회이상 입원 또는 2회이상 외래진료를 받은 어린이 코호트를 관찰하여 재발성호흡기유두종증 발생률을 추정하였다. 총 123명의 재발성호흡기유두종증 환자가 발생하였으며 (발생률 10만인년당 0.30명), 평균 첫 진단시기는 4세인 것으로 나타났다. 2회 이상 수술적 치료를 받은 경우는 18.7%였다.

Key Message
Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV). We conducted a cohort study using claims data to estimate the incidence of RRP. Patients with juvenile RRP were defined as those aged ≤12 years with ≥2 admissions or ≥2 outpatient visits with diagnosis for benign neoplasms of the larynx. During 2002-2014, 123 children were diagnosed with RRP. The incidence was estimated at 0.30/100,000 person-years. The median age at diagnosis was 4.0 years. Twenty three patients (18.7%) underwent 2 or more surgical procedures.

Citations

Citations to this article as recorded by

Global epidemiology of HPV-associated recurrent respiratory papillomatosis and effect of vaccination
RY Seedat, FG Dikkers
Future Virology.2022; 17(5): 265. CrossRef

Estimation and change of edentulism among the Korean population: Korea National Health and Nutrition Examination Survey 2007-2018: Na-Hyeon Yu, Ah Ra Shin, Song Vogue Ahn, Keun-Bae Song, Youn-Hee Choi; Epidemiol Health. 2021;43:e2021020. Published online April 2, 2021; DOI: https://doi.org/10.4178/epih.e2021020

10,848 View
302 Download
6 Web of Science
6 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
To estimate the prevalence of edentulism according to the socio-demographic variables of Korean adults between 2007 and 2018 and to analyze the trends.

METHODS

This study was conducted using raw data from the Korea National Health and Nutrition Examination Survey (KNHANES) from 2007 to 2018. Edentulism was defined as the absence of upper and lower teeth or the retained root of the missing teeth. To obtain the prevalence of edentulism, complex sample frequency analysis and regression analysis were performed according to the socio-demographic variables to represent the national population. The Korean population structure in 2005 was exploited as a standard population to calculate age-standardized edentulism.

RESULTS

The prevalence of edentulism in 2016-2018 was 9.7% in the Korean elderly, and the change of age-standardized edentulism steadily declined over time from 2007, 12.8%. In particular, it decreased by approximately 20% in the period between 2016 and 2018 compared to that in 2007 for those in their 80s. The trend of the prevalence according to gender decreased significantly in women. According to the level of education, the greatest decrease was seen in the group with the lowest education, although the prevalence itself was higher than that seen in those who were more educated.

CONCLUSIONS

The prevalence of edentulism among the older Korean population has decreased over time. However, the concern is on those with lower education and men as these groups are still at higher risk for edentulism.

Summary

Korean summary
치아상실은 구강건강의 지표로써 현재 국외에서는 무치악 유병률 추이 파악뿐만 아니라 다국 간의 비교가 이루어지고 있지만 아시아의 주요국가 중 하나인 한국의 무치악 유병률 추이에 대해서는 아직 연구되지 않았다. 연구 결과, 2016-2018년 한국 노인의 무치악 유병률은 9.72%였으며, 연령표준화된 무치악 유병률의 변화는 2007 년 12.8 %에서 꾸준히 감소했다. 결론적으로 무치악으로 어려움을 겪을 수 있는 교육수준이 낮은 노인과 남성에 대해선 지속적인 관심이 필요하다.

Key Message
Tooth loss is an indicator of oral health. At present, not only the trend of edentulous prevalence is being identified abroad, but also multi-country comparisons are being made, but the trend of edentulous prevalence in Korea, one of the major Asian countries, has not been studied. As a result of the study, the prevalence of edentulous in Korea in 2016-2018 was 9.72%, and the change in the age-standardized edentulous prevalence steadily decreased from 12.8% in 2007. In conclusion, continuous attention is needed for the elderly and men with low educational standards who may suffer from edentulous.

Citations

Citations to this article as recorded by

Comparison of the oral health status and costs of the provision of dental care in ten high-income countries
Rüdiger Saekel
Journal of Dental Health, Oral Disorders & Therapy.2024; 15(1): 23. CrossRef
Trend in the Incidence of Severe Partial Edentulism among Adults Using the Korean National Health Insurance Service Claim Data, 2014–2018
Hyeonjeong Go, Hoi-In Jung, Song Vogue Ahn, Jeonghoon Ahn, Hosung Shin, Atsuo Amano, Youn-Hee Choi
Yonsei Medical Journal.2024; 65(4): 234. CrossRef
A preclinical study comparing single- and double-root 3D-printed Ti–6Al–4V implants
Inna Chung, Jungwon Lee, Ling Li, Yang-Jo Seol, Yong-Moo Lee, Ki-Tae Koo
Scientific Reports.2023;[Epub] CrossRef
Oral health status and behavior in elderly Koreans with periodontal disease
Sae‐Rom Lee, Mi Ah Han, Jong Park, So Yeon Ryu, So Yeong Kim
Journal of Public Health Dentistry.2022; 82(4): 378. CrossRef
High exposure to phthalates is associated with HbA1c worsening in type 2 diabetes subjects with and without edentulism: a prospective pilot study
Alessandro Mengozzi, Fabrizia Carli, Samantha Pezzica, Edoardo Biancalana, Amalia Gastaldelli, Anna Solini
Diabetology & Metabolic Syndrome.2022;[Epub] CrossRef
Incidence of edentulism among older adults using the Korean National Health Insurance Service database, 2013-2018
Hyeonjeong Go, Eun-Kyong Kim, Hoi-In Jung, Song Vogue Ahn, Hosung Shin, Atsuo Amano, Youn-Hee Choi
Epidemiology and Health.2022; 44: e2022091. CrossRef

Gender role stereotypes, patriarchal attitudes, and cognitive function in the elderly rural Korean population: a cross-sectional study: Hye Rin Choi, Byeonggwan Ha, Ye Jin Jeon, Yoosik Youm, Hyeon Chang Kim, Sun Jae Jung; Epidemiol Health. 2021;43:e2021023. Published online April 7, 2021; DOI: https://doi.org/10.4178/epih.e2021023

11,196 View
356 Download
1 Web of Science
1 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
We analyzed whether gender role stereotypes (GRS) and patriarchal attitudes are associated with cognitive function in an elderly community.

METHODS

We analyzed data from 580 people enrolled in the Korean Social Life, Health, and Aging Project. The degrees to which respondents held stereotypical beliefs about gender roles and had patriarchal mindsets were measured using a questionnaire. Based on participants’ responses, we divided respondents into 2 groups—those with conservative mindsets and those with open mindsets—according to the median score for each of the 2 variables. Cognitive function was assessed using the Mini-Mental State Examination, Korean version (MMSE-K). Cognitive impairment was defined as an MMSE-K score ≤21 points. Multivariable logistic regression was performed, adjusting for gender, age, socio-demographic and lifestyle factors, and social network size. Age and lifestyle factors were stratified.

RESULTS

Compared to those with open mindsets, those with conservative mindsets regarding gender roles and patriarchal norms had adjusted odds ratios of 1.88 (95% confidence interval [CI], 1.11 to 3.19) and 1.67 (95% CI, 1.00 to 2.79) for cognitive impairment, respectively. In the stratified analysis, subgroups with younger age and a good lifestyle maintained a protective association with cognitive impairment.

CONCLUSIONS

GRS and a patriarchal mindset were marginally significantly associated with cognitive impairment among women later in life.

Summary

Korean summary
농촌지역에 거주하는 노년기 인구 580명 대상으로 성 역할 고정관념 또는 가부장적 사고가 인지기능과 연관성이 있는지 로지스틱 회귀분석을 통해 알아보았다. 분석결과, 보수적인 성 역할 고정관념과 가부장적 사고를 가진 여성에서 개방적인 사고를 가진 여성보다 인지기능이 통계적으로 유의하게 저하된 결과를 얻었다.

Key Message
We investigated whether gender role stereotypes and patriarchal attitudes are associated with cognitive function in the elderly rural Korean population. Compared to women with open attitudes, those with conservative attitudes regarding gender roles and patriarchal norms had marginally significant higher odds ratios for cognitive impairment. Thus, gender role stereotypes and a patriarchal mindset were marginally significantly associated with cognitive impairment among women later in life.

Citations

Citations to this article as recorded by

Examining the gender equity outlook and patriarchal beliefs of police constables in Allahabad, India: A machine learning approach
Saumya Tripathi
Policing: A Journal of Policy and Practice.2023;[Epub] CrossRef

Deprived areas and community water fluoridation in Brazil: a multilevel approach for refocusing public policy: Franklin Barbosa da Silva, José Leopoldo Ferreira Antunes, Paulo Frazão; Epidemiol Health. 2021;43:e2021031. Published online May 1, 2021; DOI: https://doi.org/10.4178/epih.e2021031

9,458 View
314 Download

Abstract Summary PDF: Abstract
OBJECTIVES
The aim of this study was to determine whether geographic location, socioeconomic status, infant mortality, and mortality from diarrheal disease in health regions are associated with the provision of community water fluoridation (CWF) in Brazilian municipalities.
METHODS
A multilevel ecological study was conducted based on data from the National Survey of Basic Sanitation and Human Development Atlas. A multilevel analysis was carried out considering Brazilian municipalities as the first level and health regions as the second level, comprising sanitation, demographic, socioeconomic, and health characteristics.
RESULTS
The observation units comprised 5,565 municipalities clustered in 438 health regions in Brazil. The lack of CWF provision was positively associated with the following municipal characteristics: a below-median proportion of inhabitants covered by the sewage network, medium to very low human development index, below-median per capita gross domestic product, and an above-median percentage of expenditures on sanitation. In relation to the health regions, the likelihood of a lack of CWF provision was greater in the municipalities belonging to the health regions located in the Northern and Northeastern areas of Brazil and in those where child mortality due to acute diarrheal disease and the proportion of people with low income were higher when adjusted by municipal indicators.
CONCLUSIONS
Information on the characteristics associated with CWF provision constitutes important input for refocusing public policy to reduce inequalities among Brazilian municipalities and health regions. These findings may help policy-makers to understand the challenges facing CWF expansion in low-, middle-, and high-income countries.; Summary

Key Message
Just as the challenges for CWF's expansion in Brazil's most vulnerable areas require firm leadership for refocusing public policy, expansion in low- and middle-income countries demands a continued global collaborative effort.

Effectiveness of hydrogen peroxide as auxiliary treatment for hospitalized COVID-19 patients in Brazil: preliminary results of a randomized double-blind clinical trial: Marielle Bazzo Di Domênico, Henrique Cesca, Thales Henrique Jincziwski Ponciano, Renan Brandenburg dos Santos, Ulysses Lenz, Vinícius Picoli Antunes, Vinicius Webber Godinho, Kauê Collares, Pedro Henrique Corazza; Epidemiol Health. 2021;43:e2021032. Published online May 1, 2021; DOI: https://doi.org/10.4178/epih.e2021032

15,041 View
411 Download
6 Web of Science
3 Crossref

Abstract Summary PDF

Abstract

OBJECTIVES
To evaluate the effectiveness of hydrogen peroxide (H2O2) in the form of mouthwash and nasal spray as an auxiliary treatment for coronavirus disease 2019 (COVID-19).

METHODS

Forty hospitalized patients who tested positive for severe acute respiratory syndrome coronavirus 2 using a reverse-transcription polymerase chain reaction test were evaluated. They were randomly divided into an experimental group (n= 20; gargling with 1.0% H2O2 and nasal wash with 0.5% H2O2) or a control group (n= 20). The solutions were used for 7 days and the patients were monitored every 2 days, for a total of 8 days. At check-ups, patients were asked about their symptoms and possible adverse effects of the solutions. The presence and severity (mild, moderate, or severe) of symptoms were recorded. Data were compared using the Student test and the Fisher exact test (α= 0.05).

RESULTS

There was no significant difference between the 2 groups in the length of hospital stay (p= 0.65). The most frequent symptom on day 0 was coughing (72.0% in the experimental group and 76.5% in the control group), which abated over time. There was no significant difference between the groups in the evaluated symptoms. Most (75.0%) of the patients in the experimental group presented a reduction in dyspnea between days 0 and 2. Few patients reported adverse effects from the use of the solutions.

CONCLUSIONS

H2O2 as a mouthwash and nasal spray is safe to use. There is insufficient evidence to demonstrate that H2O2 is effective as an auxiliary treatment for hospitalized COVID-19 patients.

Summary

Key Message
Despite some improvement trends in the symptom 'difficulty breathing', the effectiveness of the mouthwash and nasal spray of H2O2 for COVID-19 hospitalized patients was not proven yet.

Citations

Citations to this article as recorded by

Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review
Miriam Ting, Alex Dahlkemper, Jeremy J. Schwartz, Manzel Woodfork, Jon B. Suzuki
Biomedicines.2023; 11(6): 1694. CrossRef
The effectiveness of mouthwash against SARS-CoV-2 infection: A review of scientific and clinical evidence
Ming-Hsu Chen, Po-Chun Chang
Journal of the Formosan Medical Association.2022; 121(5): 879. CrossRef
Hydrogen peroxide as an auxiliary treatment for COVID-19 in Brazil: a randomized double-blind clinical trial
Marielle Bazzo Di Domênico, Kauê Collares, Renan Brandenburg dos Santos, Ulysses Lenz, Vinícius Picoli Antunes, Vinicius Webber Godinho, Henrique Cesca, Thales Henrique Jincziwski Ponciano, Pedro Henrique Corazza
Epidemiology and Health.2021; 43: e2021051. CrossRef

Health inequalities of 57,541 prisoners in Korea: a comparison with the general population: Seohyun Yoon, Young-Su Ju, Jaehong Yoon, Ji-Hwan Kim, Bokyoung Choi, Seung-Sup Kim; Epidemiol Health. 2021;43:e2021033. Published online May 6, 2021; DOI: https://doi.org/10.4178/epih.e2021033

10,794 View
366 Download
1 Web of Science
1 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
This study aimed to examine health disparities between prisoners and the general population in Korea.

METHODS

We sought to estimate the prevalence of 17 physical and mental diseases using the nationwide medication prescription dataset among the total population of prisoners (n=57,541) in Korea. Age- and sex- standardized prevalence ratios (SPRs) were estimated to compare the disease prevalence between the prisoners and the general population. The disease prevalence for the general population was calculated from the prescription dataset for a representative of the Korean population (n=926,246) from the 2013 Korean National Health Insurance Service-National Sample Cohort. Furthermore, the prevalence of these diseases was compared between prisoners and a low-income segment of the general population (n=159,781).

RESULTS

Compared to the general population, prisoners had higher prevalence of almost all physical and mental diseases, including hyperlipidemia (SPR, 20.18; 95% confidence interval [CI], 19.43 to 20.94), pulmonary tuberculosis (SPR, 9.58; 95% CI, 7.91 to 11.50), diabetes (SPR, 6.13; 95% CI, 5.96 to 6.31), cancer (SPR, 2.36; 95% CI, 2.07 to 2.68), and depression (SPR, 46.73; 95% CI, 44.14 to 49.43). When compared with the low-income population segment, higher prevalence were still found among prisoners for most diseases, including pulmonary tuberculosis (SPR, 6.39; 95% CI, 5.27 to 7.67) and depression (SPR, 34.71; 95% CI, 32.79 to 36.72).

CONCLUSIONS

We found that prisoners were more likely to be unhealthy than the general population, even in comparison with a low-income segment of the general population in Korea.

Summary

Korean summary
이 연구는 대한민국 재소자 전수(전국 총 52개 정부운영 교정시설 재소자 57,541명)를 대상으로 법무부 전체 구금시설 의료실태 현황조사 자료를 이용해 신체적∙정신적 건강상태를 파악하고자 하였다. 그 결과를 성∙연령별 표준화율을 적용해 일반인구집단의 국민건강보험공단 표본 코호트 자료와 비교했을 때 재소자들은 고지혈증, 폐결핵, 우울증 등 대부분의 질병에서 일반인구집단보다 더 높은 유병률을 보였다. 이러한 결과는 저소득 일반인구집단과의 비교에서도 유사하게 나타났다.

Key Message
This study aimed to assess mental and physical health conditions among the total population of 57,541 prisoners in all 52 government correctional facilities. And we sought to estimate age- and sex- standardized prevalence ratios to compare the disease prevalence between the prisoners and the general population. Prisoners were more likely to have most of physical and mental diseases (including hyperlipidemia, pulmonary tuberculosis, and depression) than the general population in Korea.

Citations

Citations to this article as recorded by

Prevalence of latent tuberculosis infection among participants of the national LTBI screening program in South Korea – A problem of low coverage rate with current LTBI strategy
Hyung Woo Kim, Jinsoo Min, Joon Young Choi, Ah Young Shin, Jun-Pyo Myong, Yunhee Lee, Hyeon Woo Yim, Hyunsuk Jeong, Sanghyuk Bae, Hoyong Choi, Hyekyung In, Ahyoung Park, Miri Jang, Hyeon-Kyoung Koo, Sung-Soon Lee, Jae Seuk Park, Ju Sang Kim
Frontiers in Public Health.2023;[Epub] CrossRef

The anatomy of COVID-19 comorbidity networks among hospitalized Korean patients: Eun Kyong Shin, Hyo Young Choi, Neil Hayes; Epidemiol Health. 2021;43:e2021035. Published online May 7, 2021; DOI: https://doi.org/10.4178/epih.e2021035

11,047 View
381 Download
3 Web of Science
3 Crossref

Abstract Summary PDF

Abstract

OBJECTIVES
We aimed to examine how comorbidities were associated with outcomes (illness severity or death) among hospitalized patients with coronavirus disease 2019 (COVID-19).

METHODS

Data were provided by the National Medical Center of the Korea Disease Control and Prevention Agency. These data included the clinical and epidemiological information of all patients hospitalized with COVID-19 who were discharged on or before April 30, 2020 in Korea. We conducted comorbidity network and multinomial logistic regression analyses to identify risk factors associated with COVID-19 disease severity and mortality. The outcome variable was the clinical severity score (CSS), categorized as mild (oxygen treatment not needed), severe (oxygen treatment needed), or death.

RESULTS

In total, 5,771 patients were included. In the fully adjusted model, chronic kidney disease (CKD) (odds ratio [OR], 2.58; 95% confidence interval [CI], 1.19 to 5.61) and chronic obstructive pulmonary disease (COPD) (OR, 3.19; 95% CI, 1.35 to 7.52) were significantly associated with disease severity. CKD (OR, 5.35; 95% CI, 2.00 to 14.31), heart failure (HF) (OR, 3.15; 95% CI, 1.22 to 8.15), malignancy (OR, 3.38; 95% CI, 1.59 to 7.17), dementia (OR, 2.62; 95% CI, 1.45 to 4.72), and diabetes mellitus (OR, 2.26; 95% CI, 1.46 to 3.49) were associated with an increased risk of death. Asthma and hypertension showed statistically insignificant associations with an increased risk of death.

CONCLUSIONS

Underlying diseases contribute differently to the severity of COVID-19. To efficiently allocate limited medical resources, underlying comorbidities should be closely monitored, particularly CKD, COPD, and HF.

Summary

Korean summary
본 연구는 2019 년 코로나 바이러스 질환 (COVID-19)으로 입원 한 환자의 합병증이 결과 (질병 중증도 또는 사망)와 어떤 관련이 있는지를 동반 질환 네트워크 및 다항 로지스틱 회귀 분석을 통해 분석하였다. 기저 질환은 COVID-19의 중증도 및 사망에 차별적으로 영향을 미친다. 제한된 의료 자원을 효율적으로 활용하기 위해서 환자의 기저 동반 질환 중, 특히 만성 신장 질환 (CKD), 만성 폐쇄성 폐 질환 (COPD), 심부전 (HF)을 더욱 면밀히 모니터링해야 한다.

Key Message
We examined how comorbidities were associated with outcomes (illness severity or death) among hospitalized patients with coronavirus disease 2019 (COVID-19), implementing comorbidity network and multinomial logistic regression analyses. Underlying diseases contribute differently to the severity of COVID-19. To efficiently allocate limited medical resources, underlying comorbidities should be closely monitored, particularly chronic kidney disease (CKD), chronic obstructive pulmonary disease (COPD), and heart failure (HF).

Citations

Citations to this article as recorded by

SARS-CoV-2 susceptibility and COVID-19 illness course and outcome in people with pre-existing neurodegenerative disorders: systematic review with frequentist and Bayesian meta-analyses
Muhannad Smadi, Melina Kaburis, Youval Schnapper, Gabriel Reina, Patricio Molero, Marc L. Molendijk
The British Journal of Psychiatry.2023; 223(2): 348. CrossRef
Asthma and COPD as co-morbidities in patients hospitalised with Covid-19 disease: a global systematic review and meta-analysis
James Patrick Finnerty, A. B. M. Arad Hussain, Aravind Ponnuswamy, Hafiz Gulzeb Kamil, Ammar Abdelaziz
BMC Pulmonary Medicine.2023;[Epub] CrossRef
The Role of Diabetes and Hyperglycemia on COVID-19 Infection Course—A Narrative Review
Evangelia Tzeravini, Eleftherios Stratigakos, Chris Siafarikas, Anastasios Tentolouris, Nikolaos Tentolouris
Frontiers in Clinical Diabetes and Healthcare.2022;[Epub] CrossRef

Health Statistics

A comparison of breast cancer survival across different age groups: a multicentric database study in Penang, Malaysia: King Fang Tan, Farzaana Adam, Hasmah Hussin, Noor Mastura Mohd Mujar; Epidemiol Health. 2021;43:e2021038. Published online May 25, 2021; DOI: https://doi.org/10.4178/epih.e2021038

13,155 View
378 Download
11 Web of Science
10 Crossref

Abstract Summary PDF

Abstract

This study compared breast cancer survival and the prognostic factors across different age groups of women in Penang, Malaysia. Data on 2,166 women with breast cancer who had been diagnosed between 2010 and 2014 were extracted from the Penang Breast Cancer Registry and stratified into 3 age groups: young (< 40 years old), middle-aged (40-59 years old), and elderly (≥ 60 years). The overall and relative survival rates were calculated using the life table method, median survival time was calculated using the Kaplan-Meier method, and comparisons between groups were conducted using the log-rank test. Prognostic factors were analyzed using a Cox proportional hazards model. The 5-year overall and breast cancer-specific survival rates for women with breast cancer in Penang were 72.9% and 75.2%, with a mean survival time of 92.5 months and 95.1 months, respectively. The 5-year breast cancer-specific survival rates for young, middle-aged, and elderly women were 74.9%, 77.8%, and 71.4%, respectively, with a mean survival time of 95.7 months, 97.5 months, and 91.2 months. There was a significant difference in breast cancer survival between age groups, with elderly women showing the lowest survival rate, followed by young and middle-aged women. Disease stage was the most prominent prognostic factor for all age groups. Survival rates and prognostic factors differed according to age group. Treatment planning for breast cancer patients should be age-specific to promote better cancer care and survival.

Summary

Key Message
The relationship between breast cancer survival and age at diagnosis has been explored, but information between survival at different age groups remains unclear, in addition to conflicting study results. This multicentre study was conducted to compare breast cancer survival across different age groups in an Asian setting.

Citations

Citations to this article as recorded by

Illuminating the breast cancer survival rates among Southeast Asian women: A systematic review and meta-analysis spanning four decades
Duc Tran Quang, Thanh Luong Thi, Khanh Nguyen Di, Chi Vu Thi Quynh, Huyen Nguyen Thi Hoa, Quang Phan Ngoc
Current Problems in Cancer.2024; 48: 101062. CrossRef
Clinical characteristics and prognostic factors of male breast cancer in China
Han Lei, Baojie Hua, Yingying Mao, Wei Cui, Caiping Mao, Shaoxue Yang, Jiayu Li
Frontiers in Oncology.2024;[Epub] CrossRef
Five-year survival prognosis of young, middle-aged, and elderly adult female invasive breast cancer patients by clinical and lifestyle characteristics
Yu-Tung Teng, Yong Alison Wang, Yaa-Hui Dong, Jason J. Liu
Breast Cancer Research and Treatment.2024;[Epub] CrossRef
Cancer–related symptoms among young and middle–aged women undergoing chemotherapy for breast cancer: Application of latent class analysis and network analysis
Tingting Cai, Tingting Zhou, Qingmei Huang, Fulei Wu, Feixia Ni, Changrong Yuan
European Journal of Oncology Nursing.2023; 63: 102287. CrossRef
myBeST—A Web-Based Survival Prognostic Tool for Women with Breast Cancer in Malaysia: Development Process and Preliminary Validation Study
Mohd Nasrullah Nik Ab Kadir, Suhaily Mohd Hairon, Najib Majdi Yaacob, Siti Norbayah Yusof, Kamarul Imran Musa, Maya Mazuwin Yahya, Seoparjoo Azmel Mohd Isa, Muhammad Hafizuddin Mamat Azlan, Imi Sairi Ab Hadi
International Journal of Environmental Research and Public Health.2023; 20(4): 2985. CrossRef
Clinical Features and Outcomes of Triple-Negative Breast Cancer Among Latin American Adolescents and Young Adults Compared to Middle-Aged and Elder Females: A Cohort Analysis Over 15 Years
Bryan Valcarcel, J. Smith Torres-Roman, Daniel Enriquez-Vera, Gabriel De-la-Cruz-Ku
Journal of Adolescent and Young Adult Oncology.2023; 12(5): 625. CrossRef
Metastasis pattern and prognosis of large cell neuroendocrine carcinoma: a population-based study
Tongchao Jiang, Haishuang Sun, Na Li, Tongcui Jiang
Journal of Cancer Research and Clinical Oncology.2023; 149(15): 13511. CrossRef
The prognostic impact of body mass index on female breast cancer patients in underdeveloped regions of northern China differs by menopause status and tumor molecular subtype
Lijun Ma, Ailan Liu, Jinnan Gao, Haoliang Zhao
Open Life Sciences.2023;[Epub] CrossRef
A Metabolic Gene Signature to Predict Breast Cancer Prognosis
Jun Lu, Pinbo Liu, Ran Zhang
Frontiers in Molecular Biosciences.2022;[Epub] CrossRef
Development of Predictive Models for Survival among Women with Breast Cancer in Malaysia
Mohd Nasrullah Nik Ab Kadir, Najib Majdi Yaacob, Siti Norbayah Yusof, Imi Sairi Ab Hadi, Kamarul Imran Musa, Seoparjoo Azmel Mohd Isa, Balqis Bahtiar, Farzaana Adam, Maya Mazuwin Yahya, Suhaily Mohd Hairon
International Journal of Environmental Research and Public Health.2022; 19(22): 15335. CrossRef

COVID-19: Original Article

Dynamics of the COVID-19 epidemic in the post-vaccination period in Korea: a rapid assessment: Kyung-Duk Min, Sangwoo Tak; Epidemiol Health. 2021;43:e2021040. Published online May 27, 2021; DOI: https://doi.org/10.4178/epih.e2021040

11,618 View
409 Download
9 Web of Science
9 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
Coronavirus disease 2019 (COVID-19) has had a tremendous impact on public health and socioeconomic conditions globally. Although non-pharmaceutical interventions (NPIs) such as social distancing effectively reduced the incidence of COVID-19, especially in Korea, demand for vaccination has increased to minimize the social costs of NPIs. This study estimated the potential benefits of COVID-19 vaccination in Korea.

METHODS

A mathematical model with vaccinated–susceptible–latent–infectious–recovered compartments was used to simulate the COVID-19 epidemic. The compartments were stratified into age groups of 0-19 years, 20-59 years, and 60 years or older. Based on the Korea Disease Control and Prevention Agency national vaccination plan for the second quarter of 2021, announced on March 15, we developed vaccination scenarios (with 150,000 dose/d and 100% compliance as the main scenario). Comparing scenarios without vaccination or with higher/lower vaccination rates and compliance, we estimated the numbers of COVID-19 cases that will be prevented by vaccination.

RESULTS

The results projected 203,135 cases within a year after April 2021 without vaccination, which would be reduced to 71,248 (64.9% decrease) by vaccination. Supposing a vaccination rate of 150,000 dose/d and 100% compliance, social distancing interventions for those aged 20 or more can be retracted after January 1, 2022.

CONCLUSIONS

We expect COVID-19 vaccination to be effective in Korea. Health authorities should minimize delays in vaccination and vaccine avoidance to maximize the effectiveness of vaccination and end social distancing early.

Summary

Korean summary
본 연구에서 국내 백신 접종 시작이후의 코로나19 유행 추이를 수학적 모형을 통하여 예측하였다. 연구 결과, 백신 접종이 전혀 진행되지 않을 경우, 2021년 4월부터 1년간 203,135 건의 확진 사례가 보고될 것으로 예측되었으나, 하루 15만 도즈의 접종이 진행될 경우 같은 기간의 확진자 수를 64.9% 감소시킬 수 있을 것으로 나타났으며, 20세 이상을 대상으로한 사회적 거리두기 정책은 2022년 1월에 중지될 수 있을 것으로 예상되었다.

Key Message
A mathematical model with vaccinated–susceptible–latent–infectious–recovered compartments was used to simulate the COVID-19 epidemic in Korea. The results projected 203,135 cases within a year after April 2021 without vaccination, which would be reduced to 71,248 (64.9% decrease) by vaccination (150,000 doses per day and 100% compliance). Supposing a vaccination rate of 150,000 doses per day and 100% compliance, social distancing intervention for those aged 20 or more can be retracted after January 1, 2022.

Citations

Citations to this article as recorded by

Predictive models for health outcomes due to SARS-CoV-2, including the effect of vaccination: a systematic review
Oscar Espinosa, Laura Mora, Cristian Sanabria, Antonio Ramos, Duván Rincón, Valeria Bejarano, Jhonathan Rodríguez, Nicolás Barrera, Carlos Álvarez-Moreno, Jorge Cortés, Carlos Saavedra, Adriana Robayo, Oscar H. Franco
Systematic Reviews.2024;[Epub] CrossRef
Mathematical Modeling of COVID-19 Transmission and Intervention in South Korea: A Review of Literature
Hyojung Lee, Sol Kim, Minyoung Jeong, Eunseo Choi, Hyeonjeong Ahn, Jeehyun Lee
Yonsei Medical Journal.2023; 64(1): 1. CrossRef
Neural network method and multiscale modeling of the COVID-19 epidemic in Korea
Ziqian Li, Jiwei Jia, Guidong Liao, Young Ju Lee, Siyu Liu
The European Physical Journal Plus.2023;[Epub] CrossRef
Impact of vaccination and non-pharmacological interventions on COVID-19: a review of simulation modeling studies in Asia
Karan Thakkar, Julia Regazzini Spinardi, Jingyan Yang, Moe H. Kyaw, Egemen Ozbilgili, Carlos Fernando Mendoza, Helen May Lin Oh
Frontiers in Public Health.2023;[Epub] CrossRef
Cost-effectiveness analysis of COVID-19 variants effects in an age-structured model
Giphil Cho, Young Jin Kim, Sang-hyup Seo, Geunsoo Jang, Hyojung Lee
Scientific Reports.2023;[Epub] CrossRef
Impact of national Covid-19 vaccination Campaign, South Korea
Seonju Yi, Young June Choe, Do Sang Lim, Hye Roen Lee, Jia Kim, Yoo-Yeon Kim, Ryu Kyung Kim, Eun Jung Jang, Sangwon Lee, Eunjoo Park, Seung-Jin Kim, Young-Joon Park
Vaccine.2022; 40(26): 3670. CrossRef
Multi-Faceted Analysis of COVID-19 Epidemic in Korea Considering Omicron Variant: Mathematical Modeling-Based Study
Youngsuk Ko, Victoria May Mendoza, Renier Mendoza, Yubin Seo, Jacob Lee, Jonggul Lee, Donghyok Kwon, Eunok Jung
Journal of Korean Medical Science.2022;[Epub] CrossRef
The economic impact of COVID-19 interventions: A mathematical modeling approach
Jung Eun Kim, Heejin Choi, Yongin Choi, Chang Hyeong Lee
Frontiers in Public Health.2022;[Epub] CrossRef
Analysis of Superspreading Potential from Transmission Clusters of COVID-19 in South Korea
Hyojung Lee, Changyong Han, Jooyi Jung, Sunmi Lee
International Journal of Environmental Research and Public Health.2021; 18(24): 12893. CrossRef

First
Prev
Page of 21
Next
Last