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Systematic review of the published data on the worldwide prevalence of John Cunningham virus in patients with multiple sclerosis and neuromyelitis optica
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Sonia Patricia Castedo Paz, Luciana Branco, Marina Alves de Camargo Pereira, Caroline Spessotto, Yara Dadalti Fragoso
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Epidemiol Health. 2018;40:e2018001. Published online January 5, 2018
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DOI: https://doi.org/10.4178/epih.e2018001
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Abstract
OBJECTIVES
John Cunningham virus (JCV) is a polyoma virus that infects humans, mainly in childhood or adolescence, and presents no symptomatic manifestations. JCV can cause progressive multifocal leukoencephalopathy (PML) in immunosuppressed individuals, including those undergoing treatment for multiple sclerosis (MS) and neuromyelitis optica (NMO). PML is a severe and potentially fatal disease of the brain. The prevalence of JCV antibodies in human serum has been reported to be between 50.0 and 90.0%. The aim of the present study was to review worldwide data on populations of patients with MS and NMO in order to establish the rates of JCV seropositivity in these individuals.
METHODS The present review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and used the following search terms: “JCV” OR “JC virus” AND “multiple sclerosis” OR “MS” OR “NMO” OR “neuromyelitis optica” AND “prevalence.” These terms were searched for both in smaller and in larger clusters of words. The databases searched included PubMed, MEDLINE, SciELO, LILACS, Google Scholar, and Embase.
RESULTS After the initial selection, 18 papers were included in the review. These articles reported the prevalence of JCV antibodies in the serum of patients with MS or NMO living in 26 countries. The systematic review identified data on 29,319 patients with MS/NMO and found that 57.1% of them (16,730 individuals) were seropositive for the anti-JCV antibody (range, 40.0 to 69.0%).
CONCLUSIONS The median worldwide prevalence of JCV among adults with MS or NMO was found to be 57.1%.
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Summary
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Citations
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Journal of Inflammation Research.2021; Volume 14: 6349. CrossRef - Infections in patients diagnosed with multiple sclerosis: A multi-database study
R. Persson, S. Lee, M. Ulcickas Yood, CAPT M. Wagner, USN, MC, N. Minton, S. Niemcryk, A. Lindholm, A.M. Evans, S.S. Jick
Multiple Sclerosis and Related Disorders.2020; 41: 101982. CrossRef - Changes in Anti-JCV Antibody Status in a Large Population of Multiple Sclerosis Patients Treated with Natalizumab
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CNS Drugs.2020; 34(5): 535. CrossRef - Two susceptible HLA-DRB1 alleles for multiple sclerosis differentially regulate anti-JC virus antibody serostatus along with fingolimod
Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Masami Tanaka, Ayako Sakoda, Fumie Hayashi, Yuji Kawano, Ryo Yamasaki, Takuya Matsushita, Jun-ichi Kira
Journal of Neuroinflammation.2020;[Epub] CrossRef - John Cunningham Virus Status, Seroconversion Rate, and the Risk of Progressive Multifocal Leukoencephalopathy in Polish John Cunningham Virus-Seronegative Patients with Relapsing-Remitting Multiple Sclerosis
Katarzyna Kapica-Topczewska, Francois Collin, Joanna Tarasiuk, Agata Czarnowska, Monika Chorąży, Anna Mirończuk, Jan Kochanowicz, Alina Kułakowska
European Neurology.2020; 83(5): 487. CrossRef - The spectrum of progressive multifocal leukoencephalopathy: a practical approach
T. Bartsch, T. Rempe, F. Leypoldt, C. Riedel, O. Jansen, D. Berg, G. Deuschl
European Journal of Neurology.2019; 26(4): 566. CrossRef - Prevalence of Anti-JC Virus (JCV) Antibodies in the Multiple Sclerosis (MS) Population in Cyprus: A Retrospective Study
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Neurology Research International.2019; 2019: 1. CrossRef - High Seroprevalence and Index of Anti-John-Cunningham Virus Antibodies in Korean Patients with Multiple Sclerosis
Su-Hyun Kim, Yeseul Kim, Ji Yun Jung, Na-Young Park, Hyunmin Jang, Jae-Won Hyun, Ho Jin Kim
Journal of Clinical Neurology.2019; 15(4): 454. CrossRef - Three cases of non-carryover fingolimod-PML
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Neurology Neuroimmunology & Neuroinflammation.2019;[Epub] CrossRef - Serum anti-JCV antibody indexes in Japanese patients with multiple sclerosis: elevations along with fingolimod treatment duration
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Journal of Neurology.2018; 265(5): 1145. CrossRef
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