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Seong Hwan Kim 1 Article
No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population
Ho Jin Kang, Byeong Moo Choe, Seong Hwan Kim, Seung-Rak Son, Kyoung-Mu Lee, Byoung Gwon Kim, Young-Seoub Hong
Epidemiol Health. 2010;32:e2010011.   Published online December 24, 2010
DOI: https://doi.org/10.4178/epih/e2010011
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  • 12 Citations
AbstractAbstract PDF
Abstract
OBJECTIVES

Common genetic SNPs in two genes, encoding catechol-O-methyltransferase (COMT) and methylenetetrahydrofolate reductase (MTHFR), which are interconnected with COMT gene regulation, have been reported to contribute to schizophrenia risk. In this study, we evaluated the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk with a case-control study in a Korean population.

METHODS

We performed a case-control study by genotyping analysis using 360 cases and 348 controls in Korean subjects to determine the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk.

RESULTS

Four functional SNPs in COMT (Val158Met and rs165599) and MTHFR (C677T and A1298C) were genotyped by primer extension assay. None of the genotype distributions for the four SNPs was significantly different between cases and controls. Stratified analysis did not show any significant gender difference for any polymorphism. In addition, we found no evidence of a gene-gene interaction in the analysis of combined genotypes.

CONCLUSION

Our results suggest no significant association between the selected functional polymorphisms of COMT or MTHFR in Korean schizophrenia subjects. However, further studies are required to confirm our findings in a larger number of subjects.

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Citations

Citations to this article as recorded by  
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    Xinyao Meng, Ji-long Zheng, Mao-ling Sun, Hai-yun Lai, Bao-jie Wang, Jun Yao, Hongbo Wang, Zezhi Li
    PLOS ONE.2022; 17(7): e0271170.     CrossRef
  • Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis
    Yu-Xin Zhang, Lu-Ping Yang, Cong Gai, Cui-Cui Cheng, Zhen-yu Guo, Hong-Mei Sun, Die Hu
    Frontiers in Psychiatry.2022;[Epub]     CrossRef
  • MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia
    Jia Hong Liu, Cheng Zhu, Ke Zheng, Wei Tang, Li Li Gao, Tammy H. Trihn, Hanjing Emily Wu, Da Chun Chen, Mei Hong Xiu, Xiang Yang Zhang
    Scientific Reports.2020;[Epub]     CrossRef
  • Effort-related decision making in humanized COMT mice: Effects of Val158Met polymorphisms and possible implications for negative symptoms in humans
    Jen-Hau Yang, Rose E. Presby, Suzanne Cayer, Renee A. Rotolo, Peter A. Perrino, R. Holly Fitch, Merce Correa, Elissa J. Chesler, John D. Salamone
    Pharmacology Biochemistry and Behavior.2020; 196: 172975.     CrossRef
  • Association of functional polymorphisms in 3′-untranslated regions of COMT, DISC1, and DTNBP1 with schizophrenia
    Zahra I. Mohamed, Shiau F. Tee, Pek Y. Tang
    Psychiatric Genetics.2018; 28(6): 110.     CrossRef
  • Role of MTHFR C677T gene polymorphism in the susceptibility of schizophrenia: An updated meta-analysis
    Upendra Yadav, Pradeep Kumar, Sanjay Gupta, Vandana Rai
    Asian Journal of Psychiatry.2016; 20: 41.     CrossRef
  • The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects
    Thelma Beatriz González-Castro, Yazmin Hernández-Díaz, Isela Esther Juárez-Rojop, María Lilia López-Narváez, Carlos Alfonso Tovilla-Zárate, Ana Fresan
    NeuroMolecular Medicine.2016; 18(2): 216.     CrossRef
  • Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis
    Shusuke Numata, Makoto Kinoshita, Atsushi Tajima, Akira Nishi, Issei Imoto, Tetsuro Ohmori
    BMC Medical Genetics.2015;[Epub]     CrossRef
  • Catechol-O-methyltransferase gene polymorphisms in Saudi cases with schizophrenia
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    Egyptian Journal of Psychiatry.2015; 36(3): 118.     CrossRef
  • Association of MTHFR C677T polymorphism with schizophrenia and its effect on episodic memory and gray matter density in patients
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    Behavioural Brain Research.2013; 243: 146.     CrossRef
  • Genetic Variation Throughout the Folate Metabolic Pathway Influences Negative Symptom Severity in Schizophrenia
    J. L. Roffman, D. G. Brohawn, A. Z. Nitenson, E. A. Macklin, J. W. Smoller, D. C. Goff
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  • No Association of Functional Polymorphisms in Methlylenetetrahydrofolate Reductase and the Risk and Minor Physical Anomalies of Schizophrenia in Korean Population
    Su-Gyeong Kim, Joo Yun Song, Eun-Jeong Joo, Seong Hoon Jeong, Se Hyun Kim, Kyu Young Lee, Nam Young Lee, Yong Min Ahn, Yong Sik Kim, Myoung-Sun Roh
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Epidemiol Health : Epidemiology and Health