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Seong Hwan Kim 2 Articles
Association of blood pressure measurements in sitting, supine, and standing positions with the 10-year risk of mortality in Korean adults
Inkyung Baik, Nan Hee Kim, Seong Hwan Kim, Chol Shin
Epidemiol Health. 2023;45:e2023055.   Published online June 8, 2023
DOI: https://doi.org/10.4178/epih.e2023055
  • 8,570 View
  • 201 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
This prospective cohort study investigated the association between blood pressure (BP) as measured in different body postures and all-cause and cardiovascular (CV) mortality risk.
METHODS
This population-based investigation included 8,901 Korean adults in 2001 and 2002. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured sequentially in the sitting, supine, and standing positions and classified into 4 categories: (1) normal, SBP <120 mmHg and DBP <80 mmHg; (2) high normal/prehypertension, SBP 120-129 mmHg and DBP <80 mmHg/SBP 130-139 mmHg or DBP 80-89 mmHg; (3) grade 1 hypertension (HTN), with SBP 140-159 mmHg or DBP 90-99 mmHg; and (4) grade 2 HTN, SBP ≥160 mmHg or DBP ≥100 mmHg. The date and cause of individual deaths were confirmed in the death record data compiled until 2013. Data were analyzed using Cox proportional hazard regression.
RESULTS
Significant associations were found between the BP categories and all-cause mortality, but only when BPs were measured in the supine position. The multivariate hazard ratios (95% confidence intervals, [CIs]) were 1.36 (95% CI, 1.06 to 1.75) and 1.59 (95% CI, 1.06 to 2.39) for grade 1 HTN and grade 2 HTN, respectively, compared with the normal category. The associations between the BP categories and CV mortality were significant regardless of body posture among participants ≥65 years, whereas they were significant for supine BP measurements only in those <65 years.
CONCLUSIONS
BP measured in the supine position predicted all-cause mortality and CV mortality better than BP measured in other postures.
Summary
Korean summary
본 역학 연구는 한국 성인 8,901명을 연구대상자로 하여 기초조사에서 세가지 자세, 즉 앉은 자세, 누운 자세, 일어선 자세에서 혈압을 측정하고, 이후 10년 동안의 사망 여부를 추적조사하여, 측정 자세에 따른 혈압과 사망 위험과의 관련성을 분석하였다. 그 결과, 누운 자세에서 측정된 고혈압(기준: 수축기 혈압이 140 mmHg 이상 혹은 이완기 혈압이 90 mmHg 이상)인 사람은 정상 혈압(기준: 수축기 혈압이 120 mmHg 미만이고 이완기 혈압이 80 mmHg 미만)인 사람에 비해 36%(1단계 고혈압) 혹은 59%(2단계 고혈압) 가량 총 사망 위험이 유의적으로 증가하는 것으로 나타났다. 이에 비해, 앉은 자세 및 일어선 자세에서 측정, 정의된 고혈압은 총 사망 위험을 증가시켰지만 유의적인 결과를 나타내지 못했다. 추후 연구에서 재확인이 필요하지만, 본 연구 결과가 시사하는 바는 앉은 자세나 일어선 자세보다 누운 자세에서 측정하는 혈압이 총 사망 위험을 더 잘 예측하므로, 고혈압 진단 외의 추가적인 활용 가능성이 있는 것으로 평가된다.
Key Message
The current epidemiological study revealed that blood pressure measured in a supine position could predict all-cause mortality and cardiovascular mortality better than blood pressure measured in a sitting or standing position. As a result, blood pressure measurements in a supine position may be useful in assessing mortality risk.

Citations

Citations to this article as recorded by  
  • Safety of midodrine in patients with heart failure with reduced ejection fraction: a retrospective cohort study
    Ming-Ju Wu, Cheng-Hsu Chen, Shang-Feng Tsai
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population
Ho Jin Kang, Byeong Moo Choe, Seong Hwan Kim, Seung-Rak Son, Kyoung-Mu Lee, Byoung Gwon Kim, Young-Seoub Hong
Epidemiol Health. 2010;32:e2010011.   Published online December 24, 2010
DOI: https://doi.org/10.4178/epih/e2010011
  • 19,786 View
  • 130 Download
  • 13 Crossref
AbstractAbstract PDF
Abstract
<sec><title>OBJECTIVES</title><p>Common genetic SNPs in two genes, encoding catechol-O-methyltransferase (COMT) and methylenetetrahydrofolate reductase (MTHFR), which are interconnected with COMT gene regulation, have been reported to contribute to schizophrenia risk. In this study, we evaluated the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk with a case-control study in a Korean population.</p></sec><sec><title>METHODS</title><p>We performed a case-control study by genotyping analysis using 360 cases and 348 controls in Korean subjects to determine the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk.</p></sec><sec><title>RESULTS</title><p>Four functional SNPs in COMT (Val158Met and rs165599) and MTHFR (C677T and A1298C) were genotyped by primer extension assay. None of the genotype distributions for the four SNPs was significantly different between cases and controls. Stratified analysis did not show any significant gender difference for any polymorphism. In addition, we found no evidence of a gene-gene interaction in the analysis of combined genotypes.</p></sec><sec><title>CONCLUSION</title><p>Our results suggest no significant association between the selected functional polymorphisms of COMT or MTHFR in Korean schizophrenia subjects. However, further studies are required to confirm our findings in a larger number of subjects.</p></sec>
Summary

Citations

Citations to this article as recorded by  
  • Molecular Mechanisms Provide a Landscape for Biomarker Selection for Schizophrenia and Schizoaffective Psychosis
    Stephanie Fryar-Williams, Jörg Strobel, Peter Clements
    International Journal of Molecular Sciences.2023; 24(20): 15296.     CrossRef
  • Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis
    Xinyao Meng, Ji-long Zheng, Mao-ling Sun, Hai-yun Lai, Bao-jie Wang, Jun Yao, Hongbo Wang, Zezhi Li
    PLOS ONE.2022; 17(7): e0271170.     CrossRef
  • Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis
    Yu-Xin Zhang, Lu-Ping Yang, Cong Gai, Cui-Cui Cheng, Zhen-yu Guo, Hong-Mei Sun, Die Hu
    Frontiers in Psychiatry.2022;[Epub]     CrossRef
  • MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia
    Jia Hong Liu, Cheng Zhu, Ke Zheng, Wei Tang, Li Li Gao, Tammy H. Trihn, Hanjing Emily Wu, Da Chun Chen, Mei Hong Xiu, Xiang Yang Zhang
    Scientific Reports.2020;[Epub]     CrossRef
  • Effort-related decision making in humanized COMT mice: Effects of Val158Met polymorphisms and possible implications for negative symptoms in humans
    Jen-Hau Yang, Rose E. Presby, Suzanne Cayer, Renee A. Rotolo, Peter A. Perrino, R. Holly Fitch, Merce Correa, Elissa J. Chesler, John D. Salamone
    Pharmacology Biochemistry and Behavior.2020; 196: 172975.     CrossRef
  • Association of functional polymorphisms in 3′-untranslated regions of COMT, DISC1, and DTNBP1 with schizophrenia
    Zahra I. Mohamed, Shiau F. Tee, Pek Y. Tang
    Psychiatric Genetics.2018; 28(6): 110.     CrossRef
  • Role of MTHFR C677T gene polymorphism in the susceptibility of schizophrenia: An updated meta-analysis
    Upendra Yadav, Pradeep Kumar, Sanjay Gupta, Vandana Rai
    Asian Journal of Psychiatry.2016; 20: 41.     CrossRef
  • The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects
    Thelma Beatriz González-Castro, Yazmin Hernández-Díaz, Isela Esther Juárez-Rojop, María Lilia López-Narváez, Carlos Alfonso Tovilla-Zárate, Ana Fresan
    NeuroMolecular Medicine.2016; 18(2): 216.     CrossRef
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    Shusuke Numata, Makoto Kinoshita, Atsushi Tajima, Akira Nishi, Issei Imoto, Tetsuro Ohmori
    BMC Medical Genetics.2015;[Epub]     CrossRef
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    Ashraf Tantawy, Abduhamid Al-Yahia, Yasser Raya, Abdurrahman Al-Mohaimeed, Ahmad Settin
    Egyptian Journal of Psychiatry.2015; 36(3): 118.     CrossRef
  • Association of MTHFR C677T polymorphism with schizophrenia and its effect on episodic memory and gray matter density in patients
    Yanling Zhang, Hao Yan, Lin Tian, Fang Wang, Tianlan Lu, Lifang Wang, Jun Yan, Qi Liu, Lan Kang, Yanyan Ruan, Dai Zhang, Weihua Yue
    Behavioural Brain Research.2013; 243: 146.     CrossRef
  • Genetic Variation Throughout the Folate Metabolic Pathway Influences Negative Symptom Severity in Schizophrenia
    J. L. Roffman, D. G. Brohawn, A. Z. Nitenson, E. A. Macklin, J. W. Smoller, D. C. Goff
    Schizophrenia Bulletin.2013; 39(2): 330.     CrossRef
  • No Association of Functional Polymorphisms in Methlylenetetrahydrofolate Reductase and the Risk and Minor Physical Anomalies of Schizophrenia in Korean Population
    Su-Gyeong Kim, Joo Yun Song, Eun-Jeong Joo, Seong Hoon Jeong, Se Hyun Kim, Kyu Young Lee, Nam Young Lee, Yong Min Ahn, Yong Sik Kim, Myoung-Sun Roh
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