Skip Navigation
Skip to contents

Epidemiol Health : Epidemiology and Health


Author index

Page Path
HOME > Browse articles > Author index
Sahar Goodarzi 1 Article
The impact of disease characteristics on multiple sclerosis patients’ quality of life
Aziz Rezapour, Abdollah Almasian Kia, Sahar Goodarzi, Mojtaba Hasoumi, Soraya Nouraei Motlagh, Sajad Vahedi
Epidemiol Health. 2017;39:e2017008.   Published online February 19, 2017
  • 16,779 View
  • 396 Download
  • 45 Web of Science
  • 43 Crossref
AbstractAbstract PDF
The aim of this study was to assess the quality of life (QoL) of patients with multiple sclerosis (MS), and to investigate the effects of characteristics of MS such as disease course, severity, and relapses on patients’ QoL.
This was a cross-sectional study, in which 171 patients were enrolled. Health-related QoL was assessed using the Persian version of the Multiple Sclerosis Quality of Life-54 questionnaire. To measure patients’ disability status, we used the Expanded Disability Status Scale. Other variables included in the study were disease course and relapses of the disease.
The average scores for patients’ physical and mental QoL were 60.9±22.3 and 59.5±21.4, respectively. In a bivariate analysis, disease course, severity of the disease, and relapses were significantly associated with the physical and mental health composite scores. In a hierarchal regression analysis, disease course, severity of the disease, and relapses were responsible for 38 and 16% of the variance in physical and mental QoL, respectively. It was also observed that relapses were a strong predictor of both physical and mental QoL.
Our results showed that disease characteristics significantly affected both dimensions of QoL. It is therefore suggested that health care providers should be aware of these characteristics of MS to more successfully improve MS patients’ QoL.


Citations to this article as recorded by  
  • Predictive Model of Anxiety and Depression Perception in Multiple Sclerosis Patients: Possible Implications for Clinical Treatment
    María Cuerda-Ballester, Antonio Bustos, David Sancho-Cantus, David Martínez-Rubio, Jesús Privado, Jorge Alarcón-Jiménez, Carlos Villarón-Casales, Nieves de Bernardo, Esther Navarro Illana, José Enrique de la Rubia Ortí
    Bioengineering.2024; 11(1): 100.     CrossRef
  • Validity and reliability of the Persian version of Recce stigma scale in people with multiple sclerosis and its impact on quality of life
    Mohammad Amin Habibi, Mohammad Yazdan Panah, Saeed Vaheb, Meysam Olfatifar, Aysa Shaygannejad, Yousef Mokary, Majid Ghasemi, Sangharsha Thapa, Vahid Shaygannejad, Omid Mirmosayyeb
    BMC Neurology.2024;[Epub]     CrossRef
  • Review on the Pharmacological Activities of Black Pepper
    D. R. Anandh, D. Priya
    Journal of Natural Remedies.2024; : 441.     CrossRef
  • Disease-modifying therapies as positive predictors of quality of life for Sudanese patients with multiple sclerosis: a cross-sectional study
    Eman Saleh Omar, Hayat M. Suliman, Bashier Osman, Safa A. Abdalla, Iman Hassan Abdoon
    The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2024;[Epub]     CrossRef
  • A theory of mind training for people with multiple sclerosis: Development of a scale to assess the treatment acceptability
    Alessia d’Arma, Annalisa Valle, Sonia Di Tella, Davide Massaro, Marco Rovaris, Francesca Baglio, Antonella Marchetti
    Current Psychology.2023; 42(14): 11586.     CrossRef
  • Neuroprotective Effects of Black Pepper and Its Bioactive Compounds in Age-Related Neurological Disorders
    Rengasamy Balakrishnan, Shofiul Azam, In-Su Kim, Dong-Kug Choi
    Aging and disease.2023; 14(3): 750.     CrossRef
  • Representing disabling experiences: Rethinking quality of life when evaluating public health interventions
    Karl Atkin, Maria Berghs, Sangeeta Chattoo
    Politics & Policy.2023; 51(1): 41.     CrossRef
  • Impact of sexual and neurogenic lower urinary tract dysfunction on multiple sclerosis patients' quality of life and health perceptions
    Cukurova Medical Journal.2023; 48(2): 448.     CrossRef
  • Interventions to Improve Quality of Life in Multiple Sclerosis: New Opportunities and Key Talking Points
    Erin Faraclas
    Degenerative Neurological and Neuromuscular Disease.2023; Volume 13: 55.     CrossRef
  • Perceived health- related quality of life in persons with multiple sclerosis with and without a vascular comorbidity
    Lindsay O. Neto, Jennifer A. Ruiz, Elizabeth S. Gromisch
    Quality of Life Research.2023;[Epub]     CrossRef
  • Factors that influence quality of life in patients with multiple sclerosis in Saudi Arabia
    Fuad A. Abdulla, Faisal M. Albagmi, Fahd A. Al-Khamis
    Disability and Rehabilitation.2022; 44(17): 4775.     CrossRef
  • Analysis of frequency and severity of relapses in multiple sclerosis patients treated with cladribine tablets or placebo: The CLARITY and CLARITY Extension studies
    Nicola De Stefano, Maria Pia Sormani, Gavin Giovannoni, Kottil Rammohan, Thomas Leist, Patricia K Coyle, Fernando Dangond, Birgit Keller, Nektaria Alexandri, Andrew Galazka
    Multiple Sclerosis Journal.2022; 28(1): 111.     CrossRef
  • Short quality of life scale: A cross-cultural validation in Iranian patients with multiple sclerosis
    Samira Zarrabi-Ajami, Hadi Zamanian, Mohammadali Amini-Tehrani, Zahra Farhadidanaloo, Razieh Janati Razavi, Azam Abbasi, Saeideh Darbandi, Pegah Chenari
    Multiple Sclerosis and Related Disorders.2022; 58: 103411.     CrossRef
  • Therapeutic Potential of Combined Therapy of Vitamin A and Vitamin C in the Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats
    Mojdeh Navidhamidi, Atena Nazari, Samaneh Dehghan, Anahita Ebrahimpour, Reza Nasrnezhad, Fereshteh Pourabdolhossein
    Molecular Neurobiology.2022; 59(4): 2328.     CrossRef
  • Health-Related Quality of Life in people with Multiple Sclerosis: How does this Population Compare to Population-based Norms in Different Health Domains?
    Erin Faraclas, Jeff Lynn, Jeffery D. Lau, Angela Merlo
    Journal of Patient-Reported Outcomes.2022;[Epub]     CrossRef
  • Pelvic floor muscle training in multiple sclerosis patients with lower urinary tract dysfunction: A systematic review and meta-analysis
    Mehrnaz Kajbafvala, Zinat Ashnagar, Adelia Lucio, Fahimeh Firoozeh, Reza Salehi, Fariba Pashazadeh, Mehdi Dadgoo, Hassan Jafari
    Multiple Sclerosis and Related Disorders.2022; 59: 103559.     CrossRef
  • Improvement of gait and balance in patients with multiple sclerosis after multidisciplinary physical rehabilitation: Analysis of real-world data in Russia
    A. Stepanova, G Makshakov, A. Kulyakhtin, I. Kalinin, P Feys, E. Evdoshenko
    Multiple Sclerosis and Related Disorders.2022; 59: 103640.     CrossRef
  • The Relationship Between Adaptation to Disease and Self-care Agency Levels in Patients With Multiple Sclerosis
    Aysun Bayram, Afife Yurttaş
    Journal of Neuroscience Nursing.2022; 54(2): 102.     CrossRef
  • The validity, responsiveness, and score interpretation of the PROMISnq Physical Function – Multiple Sclerosis 15a short form in multiple sclerosis
    Paul Kamudoni, Dagmar Amtmann, Jeffrey Johns, Karon F. Cook, Rana Salem, Sam Salek, Jana Raab, Rod Middleton, Pavle Repovic, Kevin N. Alschuler, Gloria von Geldern, Annette Wundes, Amy Barrett, Oyebimpe Olayinka-Amao, Christian Henke
    Multiple Sclerosis and Related Disorders.2022; 62: 103753.     CrossRef
  • Fatigue, Depression, and Anxiety Among Ambulating Multiple Sclerosis Patients
    Safanah AlSaeed, Tamadher Aljouee, Nuha M. Alkhawajah, Rola Alarieh, Hanan AlGarni, Salman Aljarallah, Mohsen Ayyash, Amani Abu-Shaheen
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Age, motor dysfunction and neuropsychiatric symptoms impact quality of life in multiple sclerosis
    Patrícia de Morais Ferreira Brandão, Tayla Borges Lino, Renata Terra de Oliveira, Andrelisa Vendrami Parra, Paulo Henrique Muleta Andrade, Gustavo Christofoletti
    Revista Brasileira de Enfermagem.2022;[Epub]     CrossRef
  • Avoidant Coping Is Associated with Quality of Life in Persons with Multiple Sclerosis with High Cognitive Reserve
    Samantha M Vervoordt, Megan L Bradson, Peter A Arnett
    Archives of Clinical Neuropsychology.2022; 37(7): 1527.     CrossRef
  • Impact of autologous HSCT on the quality of life and fatigue in patients with relapsing multiple sclerosis
    N. Giedraitiene, G. Gasciauskaite, G. Kaubrys
    Scientific Reports.2022;[Epub]     CrossRef
  • Perceived facilitators, needs, and barriers to health related quality of life in people with multiple sclerosis: a qualitative investigation
    Erin Faraclas, Angela Merlo, Jeff Lynn, Jeffery D. Lau
    Journal of Patient-Reported Outcomes.2022;[Epub]     CrossRef
  • Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis
    Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús Romero-Imbroda, Oscar Fernández, Laura Leyva, Fernando Rodríguez de Fonseca, Jerold Chun, Celine Louapre, Anne Baron Van-Evercooren, Violetta Zujovic, Guillermo Estivill-Torrús, Beatriz García-Díaz
    Molecular Neurobiology.2021; 58(2): 470.     CrossRef
  • Multipl Skleroz Tanılı ve Sağlıklı Kadınların Alt Üriner Sistem Semptomlarının Karşılaştırılması
    Anadolu Kliniği Tıp Bilimleri Dergisi.2021; 26(2): 143.     CrossRef
  • Perceived social support, mental health, and marital satisfaction in multiple sclerosis patients
    Şükrü Özen, Tuğba Karataş, Ülkü Polat
    Perspectives in Psychiatric Care.2021; 57(4): 1862.     CrossRef
  • Virtual reality is a feasible intervention platform in multiple sclerosis: A pilot protocol and acute improvements in affect
    Michael T. Shaw, Maria J. Palmeri, Martin Malik, Bryan Dobbs, Leigh E. Charvet
    Multiple Sclerosis Journal - Experimental, Translational and Clinical.2021; 7(2): 205521732110061.     CrossRef
  • Sensorimotor function does not predict quality of life in persons with multiple sclerosis
    Philipp Gulde, Joachim Hermsdörfer, Peter Rieckmann
    Multiple Sclerosis and Related Disorders.2021; 52: 102986.     CrossRef
  • Fear of relapse in patients suffering from RRMS influence their quality of life
    Ali Khatibi, Tracey J Weiland, Mohsen Dehghani
    Multiple Sclerosis and Related Disorders.2021; 54: 103137.     CrossRef
  • Piperine Improves Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats Through its Neuroprotective, Anti-inflammatory, and Antioxidant Effects
    Reza Nasrnezhad, Sohrab Halalkhor, Farzin Sadeghi, Fereshteh Pourabdolhossein
    Molecular Neurobiology.2021; 58(11): 5473.     CrossRef
  • Quality of Life of Children and Adolescents with Multiple Sclerosis—A Literature Review of the Quantitative Evidence
    Slávka Mrosková, Eleonóra Klímová, Ľudmila Majerníková, Ľubomíra Tkáčová
    International Journal of Environmental Research and Public Health.2021; 18(16): 8645.     CrossRef
  • Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype
    Nupur Nag, Maggie Yu, George Jelinek, Steve Simpson-Yap, Sandra Neate, Hollie Schmidt
    Journal of Personalized Medicine.2021; 11(11): 1218.     CrossRef
  • Coping Strategies and Their Impact on Quality of Life and Physical Disability of People with Multiple Sclerosis
    Silvia Cerea, Marta Ghisi, Marco Pitteri, Maddalena Guandalini, Lauren B. Strober, Simona Scozzari, Francesco Crescenzo, Massimiliano Calabrese
    Journal of Clinical Medicine.2021; 10(23): 5607.     CrossRef
  • The Relationship Between Aspects of Resiliency and Intimacy-Related Illness Intrusiveness in Males with Multiple Sclerosis
    Lindsay Neto, Elizabeth S. Gromisch, Jessica Sloan, Tuula Tyry, Frederick W. Foley
    Sexuality and Disability.2020; 38(1): 135.     CrossRef
  • Health-Related Quality of Life and the Relationship to Treatment Satisfaction in Patients with Multiple Sclerosis: Insights from a Large Observational Study

    Dirk Schriefer, Rocco Haase, Jennifer S Kullmann, Tjalf Ziemssen
    Patient Preference and Adherence.2020; Volume 14: 869.     CrossRef
  • Quality of life among patients with multiple sclerosis and voiding dysfunction: a cross-sectional study
    Fatemeh Nazari, Vahid Shaygannejad, Mehrdad Mohammadi Sichani, Marjan Mansourian, Valiollah Hajhashemi
    BMC Urology.2020;[Epub]     CrossRef
  • Mindfulness-Based Interventions for the Improvement of Well-Being in People With Multiple Sclerosis: A Systematic Review and Meta-Analysis
    Sara Carletto, Cesare Cavalera, Isabel Sadowski, Marco Rovaris, Martina Borghi, Bassam Khoury, Luca Ostacoli, Francesco Pagnini
    Psychosomatic Medicine.2020; 82(6): 600.     CrossRef
  • Der Einfluss von MS-spezifischen Symptomen auf die gesundheitsbezogene Lebensqualität
    Lydia Sander, Joachim Kugler, Bernhard Elsner
    Fortschritte der Neurologie · Psychiatrie.2020; 88(11): 704.     CrossRef
  • Quality of life in adults with multiple sclerosis: a systematic review
    Irene Gil-González, Agustín Martín-Rodríguez, Rupert Conrad, María Ángeles Pérez-San-Gregorio
    BMJ Open.2020; 10(11): e041249.     CrossRef
  • Sex differences in predictors of illness intrusiveness in persons with multiple sclerosis
    Lindsay O. Neto, Elizabeth S. Gromisch, Jessica Sloan, Tuula Tyry, Frederick W. Foley
    Quality of Life Research.2019; 28(2): 389.     CrossRef
  • Validation of the Indonesian version of multiple sclerosis quality of life-54 (MSQOL-54 INA) questionnaire
    Riwanti Estiasari, Syarly Melani, A. A. A. Agung Kusumawardhani, David Pangeran, Yuhyi Fajrina, Kartika Maharani, Darma Imran
    Health and Quality of Life Outcomes.2019;[Epub]     CrossRef
  • A Controlled Clinical Trial on the Effects of Exercise on Lower Urinary Tract Symptoms in Women With Multiple Sclerosis
    Ana Paula Silva Ferreira, Ana Beatriz Gomes de Souza Pegorare, Ari Miotto Junior, Pedro Rippel Salgado, Fausto Orsi Medola, Gustavo Christofoletti
    American Journal of Physical Medicine & Rehabilitation.2019; 98(9): 777.     CrossRef

Epidemiol Health : Epidemiology and Health