-
Temporal trends in the prevalence, incidence, and mortality of cardiac amyloidosis in Korea over 12 years
-
You-Jung Choi, Yun Jin Choi, Jieun Lee, Jah Yeon Choi, Geum Joon Cho, Jin Oh Na
-
Epidemiol Health. 2024;46:e2024078. Published online September 15, 2024
-
DOI: https://doi.org/10.4178/epih.e2024078
-
-
Abstract
Summary
PDF Supplementary Material
-
Abstract
OBJECTIVES This study investigated the prevalence, incidence, and prognosis of cardiac amyloidosis (CA) in Korea.
METHODS This retrospective nationwide population-based study used the Health Insurance Review and Assessment Service databases between 2008 and 2020. All patients diagnosed with amyloidosis were included, and those with a diagnosis of heart failure or cardiomyopathy were classified as having CA. Both the special code for amyloidosis (V121), which enables coverage of medical expenses, and the corresponding International Classification of Diseases, 10th revision codes for amyloidosis (E850- E854, E858, E859) were used to improve the reliability of amyloidosis diagnosis.
RESULTS Among 2,239 patients with amyloidosis, 758 met the criteria for CA (mean age, 64.4±11.9 years; 59.1% male). The mean age of patients with CA increased from 59.5±14.7 years in 2009 to 68.1±13.9 years in 2020. The incidence and prevalence increased from 0.09 (95% confidence interval [CI], 0.06 to 0.12) to 0.22 (95% CI, 0.18 to 0.27) per 100,000 person-years and 0.20 (95% CI, 0.16 to 0.25) to 1.30 (95% CI, 0.12 to 0.42) per 100,000 persons, respectively (all p<0.001). Patients with light-chain CA showed similar trends. In-hospital mortality decreased from 17.3% (95% CI, 9.23 to 29.6) to 6.10% (95% CI, 4.21 to 8.48) between 2009 and 2020. While age-specific in-hospital mortality was significantly higher in patients aged ≥70 years (p=0.004), no significant age-specific difference in in-hospital mortality was observed in patients with CA aged <70 years (p=0.981).
CONCLUSIONS The prevalence and incidence of CA have increased in Korea, predominantly affecting older individuals, particularly males. Notably, in-hospital mortality decreased significantly.
-
Summary
Korean summary
본 연구는 2009년부터 2020년까지 한국에서의 심장 아밀로이드증의 역학을 조사했으며, 유병률과 발생률이 시간이 지남에 따라 유의미하게 증가하고, 환자의 평균 연령도 높아지는 추세를 보였습니다. 특히, 전체 환자에서 입원 중 사망률이 크게 감소하며 치료와 관리가 개선되었음을 보여주었으나, 70세 이하에서는 심장 아밀로이드증으로 인한 사망이 나이에 따른 차이를 보이지 않아 조기 발견 및 적극적인 치료의 중요성이 강조되었습니다.
Key Message
This study investigated the epidemiology of cardiac amyloidosis in South Korea from 2009 to 2020, revealing a significant increase in prevalence and incidence over time, along with a rise in the median age of patients. Notably, in-hospital mortality decreased substantially across all patients, reflecting improvements in treatment and management. However, among patients under 70 years of age, mortality due to cardiac amyloidosis showed no significant age-related differences, underscoring the importance of early detection and proactive treatment.
|