Skip Navigation
Skip to contents

Epidemiol Health : Epidemiology and Health

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Browse articles > Author index
Search
Hossein Ali Adineh 1 Article
The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran
Alireza Ansari-Moghaddam, Hossein Ali Adineh, Iraj Zareban, Mehdi Mohammadi, Mahtab Maghsoodlu
Epidemiol Health. 2018;40:e2018048.   Published online October 3, 2018
DOI: https://doi.org/10.4178/epih.e2018048
  • 9,153 View
  • 248 Download
  • 13 Citations
AbstractAbstract PDF
Abstract
OBJECTIVES
Thalassemia is a common genetic disease in Iran, especially in the north and south of Iran. The present study sought to determine the survival rate of patients with thalassemia in highly endemic regions of Iran and its variation in patients born before and after 1971.
METHODS
The present historical cohort study extracted data from the health records of patients with beta-thalassemia major, beta-thalassemia intermedia, and sickle beta-thalassemia who had presented to thalassemia treatment centers in the past years. The collected data were analyzed using the Kaplan-Meier test, the log-rank test, and the chi-square test.
RESULTS
Of the total of 5,491 medical records (2,647 men and 2,634 women; mean age, 23.81±11.32 years), 3,936 belonged to patients with beta-thalassemia major, and 999 and 89 to patients with beta-thalassemia intermedia and sickle beta-thalassemia, respectively. In 467 cases, the type of thalassemia was not clear. The cumulative survival rate was calculated as 0.92, 0.83, 0.74, and 0.51 by ages 25, 35, 45, and 55, respectively. The hazard ratio of death was 4.22 (p<0.05) for beta-thalassemia major and 0.77 for beta-thalassemia intermedia (p=0.70). It was calculated as 1.45 for men patients and as 3.82 for single patients.
CONCLUSIONS
The present study showed relatively high survival rates in patients with thalassemia. The survival of patients was unfavorable in poorer regions (Zahedan and Iranshahr). Factors including women gender, a higher level of education, being married, and living in metropolises decreased the risk of death at younger ages and improved survival.
Summary
Korean summary
Key Message

Citations

Citations to this article as recorded by  
  • Prevalence and risk factors of fractures in transfusion dependent thalassemia – A Hong Kong Chinese population cohort
    Samantha Lai Ka Lee, Raymond Siu Ming Wong, Chi Kong Li, Wing Kwan Leung
    Endocrinology, Diabetes & Metabolism.2022;[Epub]     CrossRef
  • Estimation of the prevalence of Hemoglobinopathies in Erbil governorate, Kurdistan region of Iraq
    SarkarS Aziz, BahraK Hamad, HeroO Hamad, MuzhdaI Qader, EmanN Ali, RayanH Muhammed, MudhirSabir Shekha
    Iraqi Journal of Hematology.2022; 11(1): 19.     CrossRef
  • Thalassaemia
    Antonis Kattamis, Janet L Kwiatkowski, Yesim Aydinok
    The Lancet.2022; 399(10343): 2310.     CrossRef
  • Bone Mineral Density, Serum Calcium, and Vitamin D Levels in Adult Thalassemia Major Patients: Experience From a Single Center in Eastern India
    Soumya Santra, Kunal Sharma, Ipsita Dash, Shaikat Mondal, Himel Mondal
    Cureus.2022;[Epub]     CrossRef
  • Thalassemia Intermedia: Chelator or Not?
    Yen-Chien Lee, Chi-Tai Yen, Yen-Ling Lee, Rong-Jane Chen
    International Journal of Molecular Sciences.2022; 23(17): 10189.     CrossRef
  • The Outcomes of Patients with Haemoglobin Disorders in Cyprus: A Joined Report of the Thalassaemia International Federation and the Nicosia and Paphos Thalassaemia Centres (State Health Services Organisation)
    Michael Angastiniotis, Soteroula Christou, Annita Kolnakou, Evangelia Pangalou, Irene Savvidou, Dimitrios Farmakis, Androulla Eleftheriou
    Thalassemia Reports.2022; 12(4): 143.     CrossRef
  • Investigating the effectiveness of Case‐Based Technology‐Enhanced workshops ( e‐Flipped vs. Online) among health worker nurses during the COVID ‐19 pandemic
    Nahid Zarifsanaiey, Roghaye Sajjadian, Zahra Karimian, Laleh Khojasteh, Hadi Raeisi Shahraki
    Nursing Open.2022;[Epub]     CrossRef
  • Abnormal diastolic function and Global longitudinal strain in patients with Thalassemia Major on long term chelation therapy
    Sunil K. Nadar, Shahina Daar, Wael A. Abdelmottaleb, Muhammad M. Shaikh, Hafsa Al Mahrouqi, Majida Al-Raiisi, Moez Hassan, Badar Al Rawahi, Sarah Al Rahbi
    The International Journal of Cardiovascular Imaging.2021; 37(2): 643.     CrossRef
  • The effect of curcumin on serum copper, zinc, and zinc/copper ratio in patients with β-thalassemia intermedia: a randomized double-blind clinical trial
    Mohammadreza Saeidnia, Peyman Nowrouzi-Sohrabi, Mehran Erfani, Pooria Fazeli, Gholamhossein Tamaddon, Mehran Karimi
    Annals of Hematology.2021; 100(3): 627.     CrossRef
  • The Prevention of Thalassemia Revisited: A Historical and Ethical Perspective by the Thalassemia International Federation
    Michael Angastiniotis, Mary Petrou, Dimitrios Loukopoulos, Bernadette Modell, Dimitrios Farmakis, Panos Englezos, Androulla Eleftheriou
    Hemoglobin.2021; 45(1): 5.     CrossRef
  • Developing a databank for multiple transfusion patients: Rh antigen and phenotype distribution among 3000 regular blood donors in Iran
    Zahra Bakhshandeh, Naser Amirizadeh, Mahtab Maghsoodlu, Arezoo Oodi, Amirali Naghi, Ali Arab Khazaeli, Azita Azarkeivan
    Transfusion and Apheresis Science.2021; 60(3): 103124.     CrossRef
  • Thalassemia-Beta major-Case report
    Ambarkova Vesna, Krmzova Tina, Nonkulovski Zoran
    Archives of Hematology Case Reports and Reviews.2021; : 021.     CrossRef
  • An insight into Indonesian current thalassaemia care and challenges
    Pustika Amalia Wahidiyat, Teny Tjitra Sari, Ludi Dhyani Rahmartani, Iswari Setianingsih, Stephen Diah Iskandar, Anastasia Michelle Pratanata, Ivana Yapiy, Mikhael Yosia, Fernando Tricta
    ISBT Science Series.2020; 15(3): 334.     CrossRef

Epidemiol Health : Epidemiology and Health