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Sero-prevalence of Hepatitis B Virus Surface Antigen and Antibody in High School Students in Chungju-city.
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Hyeongsu Kim, Kun Sei Lee, Soung Hoon Chang, Suekyung Park, Cheongsik Kim, Chang Hee Lee, Hyuk Jung Kweon, Soon Sup Chung
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Korean J Epidemiol. 2002;24(2):107-112.
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 Abstract
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Abstract
OBJECTIVES
Since Korea has been known to be one of the endemic area for hepatitis B virus(HBV) infection, vaccination for HBV has been recommended for all neonates in Korea. After starting vaccination in 1983, the change of sero-positivity of HBsAg and HBsAb is expected. This study was carried out to investigate the seropositive rate of hepatitis B virus surface antigen and antibody in high school freshmen students in Chungju-city.METHODS AND MATERIALS: From 1998 to 2001, a total of 11,735 who were born in 1982 to 1986, were enrolled in this study.
HBsAg and anti-HBs were tested by reversed passive hemagglutination and passive hemagglutination, respectively.
PESULTS: The study population was 11,735 students who were composed of 5,813 males (49.6%) and 5,914 females (50.4%).
The HBsAg sero-positivity of male and female students was 3.25% (n=381) and 2.59% (n=153) respectively. The anti-HBs sero-positivity of male and female students was 62.2% (n=3,154) and 64.1% (n=2,969) respectively. There are significant difference observed in comparison of HBsAg and anti-HBs seropositivity according to sex (p<0.05). From 1982 to 1986 on birth year, anti-HBs sero-positivity has been increased significantly from 63.3% to 73.3%. But the change of HBsAg sero-positivity has not been changed significantly.CONCLUSIONS As compared with previous studies of HBsAg and anti-HBs, the sero-positive rate of HBsAg has not been changed but that of HBsAb has been increased significantly.
This result revealed that the effect of HBV vaccination program was successful.
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