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Charlotte Warren-Gash 1 Article
Data resource profile: the National Health Insurance Research Database (NHIRD)
Liang-yu Lin, Charlotte Warren-Gash, Liam Smeeth, Pau-Chung Chen
Epidemiol Health. 2018;40:e2018062.   Published online December 27, 2018
DOI: https://doi.org/10.4178/epih.e2018062
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AbstractAbstract PDFSupplementary Material
Abstract
Electronic health records (EHRs) can provide researchers with extraordinary opportunities for population-based research. The National Health Insurance system of Taiwan was established in 1995 and covers more than 99.6% of the Taiwanese population; this system’s claims data are released as the National Health Insurance Research Database (NHIRD). All data from primary outpatient departments and inpatient hospital care settings after 2000 are included in this database. After a change and update in 2016, the NHIRD is maintained and regulated by the Data Science Centre of the Ministry of Health and Welfare of Taiwan. Datasets for approved research are released in three forms: sampling datasets comprising 2 million subjects, disease-specific databases, and full population datasets. These datasets are de-identified and contain basic demographic information, disease diagnoses, prescriptions, operations, and investigations. Data can be linked to government surveys or other research datasets. While only a small number of validation studies with small sample sizes have been undertaken, they have generally reported positive predictive values of over 70% for various diagnoses. Currently, patients cannot opt out of inclusion in the database, although this requirement is under review. In conclusion, the NHIRD is a large, powerful data source for biomedical research.
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    Neuropsychiatric Disease and Treatment.2021; Volume 17: 2315.     CrossRef
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    International Journal of Chronic Obstructive Pulmonary Disease.2021; Volume 16: 2721.     CrossRef
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  • The dialysis facility levels and sizes are associated with outcomes of incident hemodialysis patients
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  • Association of Acute Upper Respiratory Tract Infections with Sudden Sensorineural Hearing Loss: A Case-Crossover, Nationwide, Population-Based Cohort Study
    Chuan-Yi Lin, Po-Hsiu Kuo, Szu-Yuan Wu
    International Journal of Environmental Research and Public Health.2021; 18(20): 10745.     CrossRef
  • Effect of Nephrology Care on Mortality in Incident Dialysis Patients: A Population-Based Cohort Study
    Cheng-Yin Chung, Ping-Hsun Wu, Yi-Wen Chiu, Shang-Jyh Hwang, Ming-Yen Lin
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  • Coprescription Trends in Western Medicine, Chinese Herbal Medicine and Dental Medicine among Older Adults in Taiwan from 1997 to 2013
    Chia-Yu Huang, Mei-Yao Wu, Chia-Ling Chang, Yuan-Ching Liao, Ying-Yu Chen, Wu-Chou Lin, Hung-Rong Yen
    Complementary Therapies in Medicine.2021; 63: 102782.     CrossRef
  • High Risk for Attention-Deficit Hyperactive Disorder in Children with Strabismus: A Nationwide Cohort Study from the National Health Insurance Research Database
    Chia-Ying Tsai, Chien-Chia Su, Yao-Lin Liu, I-Ju Tsai, Tzu-Hsun Tsai
    Life.2021; 11(11): 1139.     CrossRef
  • Comparison of Medical Comorbidity between Patients with Normal-Tension Glaucoma and Primary Open-Angle Glaucoma: A Population-Based Study in Taiwan
    Wei-Yang Lu, Ci-Wen Luo, Shyan-Tarng Chen, Yu-Hsiang Kuan, Shun-Fa Yang, Han-Yin Sun
    Healthcare.2021; 9(11): 1509.     CrossRef
  • Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study
    Chin-Chia Wu, Cheng-Hung Lee, Ta-Wen Hsu, Chia-Chou Yeh, Mei-Chen Lin, Chun-Ming Chang, Jui-Hsiu Tsai
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  • Association between different systemic therapies and the risk of tuberculosis in psoriasis patients: A population‐based study
    Sze‐Wen Ting, Sze‐Ya Ting, Yu‐Sheng Lin, Ming‐Shyan Lin, George Kuo
    International Journal of Clinical Practice.2021;[Epub]     CrossRef
  • Differential Presentations of Arterial Thromboembolic Events Between Venous Thromboembolism and Atrial Fibrillation Patients
    Yu-Sheng Lin, Ming-Shyan Lin, Victor Chien-Chia Wu, Yung-Lung Chen, Jung-Jung Chang, Pao-Hsien Chu, Gregory Y. H. Lip, Mien-Cheng Chen
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  • Developing the New National Patient Sample and Evaluating Representations
    Chul Young Yoon, Jae Joon Ahn, Gyeongmin Lee, Yongseok Choi, Lihyun Kim, Dae Yoo Ha, Ki-Bong Yoo
    Health Insurance Review & Assessment Service Research.2021; 1(2): 166.     CrossRef
  • Economic evaluation of transferring first-stroke survivors to rehabilitation wards: A 10-year longitudinal, population-based study
    Chien-Min Chen, Yao-Hsu Yang, Meng Lee, Kai-Hua Chen, Shih-Shin Huang
    Topics in Stroke Rehabilitation.2020; 27(1): 8.     CrossRef
  • Risk of preventable hospitalization before and after diagnosis among rheumatoid arthritis patients compared to non-rheumatoid arthritis controls
    Chang-Fu Kuo, Patricia B. Burns, Jung-Sheng Chen, Lu Wang, Kevin C. Chung
    Joint Bone Spine.2020; 87(2): 149.     CrossRef
  • Examining the Potential of Blockchain Technology to Meet the Needs of 21st-Century Japanese Health Care: Viewpoint on Use Cases and Policy
    Tim Mackey, Hirofumi Bekki, Tokio Matsuzaki, Hiroshi Mizushima
    Journal of Medical Internet Research.2020; 22(1): e13649.     CrossRef
  • Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study
    Nen-Chung Chang, Patrick Hu, Tien-Hsing Chen, Chun-Tai Mao, Ming-Jui Hung, Chi-Tai Yeh, Ming-Yow Hung, Giuseppe Coppola
    PLOS ONE.2020; 15(1): e0227571.     CrossRef
  • Biologic Agents Reduce Cardiovascular Events in Rheumatoid Arthritis Not Responsive to Tumour Necrosis Factor Inhibitors: A National Cohort Study
    Ming-Jer Hsieh, Cheng-Hung Lee, Ming-Lung Tsai, Chang-Fu Kao, Wen-Ching Lan, Yu-Tung Huang, Wen-Yi Tseng, Ming-Shien Wen, Shang-Hung Chang
    Canadian Journal of Cardiology.2020; 36(11): 1739.     CrossRef
  • Increased Risk of Systemic Lupus Erythematosus in Patients With Helicobacter pylori Infection: A Nationwide Population-Based Cohort Study
    Meng-Che Wu, Pui-Ying Leong, Jeng-Yuan Chiou, Huang-Hsi Chen, Jing-Yang Huang, James Cheng-Chung Wei
    Frontiers in Medicine.2020;[Epub]     CrossRef
  • The incidence of collagen-associated adverse events in pediatric population with the use of fluoroquinolones: a nationwide cohort study in Taiwan
    Pei-Han Yu, Chih-Fen Hu, Jen-Wei Liu, Chi-Hsiang Chung, Yong-Chen Chen, Chien-An Sun, Wu-Chien Chien
    BMC Pediatrics.2020;[Epub]     CrossRef
  • Are Anticholinergic Medications Associated With Increased Risk of Dementia and Behavioral and Psychological Symptoms of Dementia? A Nationwide 15-Year Follow-Up Cohort Study in Taiwan
    Yia-Ping Liu, Wu-Chien Chien, Chi-Hsiang Chung, Hsin-An Chang, Yu-Chen Kao, Nian-Sheng Tzeng
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • The impact of colectomy on the risk of cardiovascular disease among patients without colorectal cancer
    Chin-Chia Wu, Ta-Wen Hsu, Chia-Chou Yeh, Cheng-Hung Lee, Mei-Chen Lin, Chun-Ming Chang
    Scientific Reports.2020;[Epub]     CrossRef
  • Associations Between Periodontal Health/Treatment and Cognitive Impairment: Latest Evidence From Epidemiological Studies
    Misuzu Sato, Masanori Iwasaki, Kumiko Minagawa, Akane Miyamoto
    Current Oral Health Reports.2020; 7(2): 119.     CrossRef
  • Validity of ICD-10-CM Codes Used to Identify Patients with Chronic Hepatitis B and C Virus Infection in Administrative Claims Data from the Taiwan National Health Insurance Outpatient Claims Dataset


    Ming-Jen Sheu, Fu-Weng Liang, Sheng-Tung Li, Chung-Yi Li, Tsung-Hsueh Lu
    Clinical Epidemiology.2020; Volume 12: 185.     CrossRef
  • Preadmission Antihypertensive Drug Use and Sepsis Outcome: Impact of Angiotensin-Converting Enzyme Inhibitors (ACEIs) and Angiotensin Receptor Blockers (ARBs)
    Ming-Shun Hsieh, Chorng-Kuang How, Vivian Chia-Rong Hsieh, Pau-Chung Chen
    Shock.2020; 53(4): 407.     CrossRef
  • Continuity of Care Is Associated with Medical Costs and Inpatient Days in Children with Cerebral Palsy
    Kuang-Tsu Yang, Chun-Hao Yin, Yao-Min Hung, Shih-Ju Huang, Ching-Chih Lee, Tsu-Jen Kuo
    International Journal of Environmental Research and Public Health.2020; 17(8): 2913.     CrossRef
  • Effect of early eradication therapy on systemic lupus erythematosus risk in patients with Helicobacter pylori infection: a nationwide population-based cohort study
    Meng-Che Wu, Jing-Yang Huang, Huang-Hsi Chen, James Cheng-Chung Wei
    Lupus.2020; 29(7): 751.     CrossRef
  • Association Between Attention Deficit Hyperactivity Disorder and Risk of Burn Injury: A Propensity-Matched Cohort Study


    Jia-Yin Yeh, Tsai-Yu Hou, Wei-Ting Tseng, Vincent Chin-Hung Chen, Yao-Hsu Yang, Ting-Yu Kuo, Jun-Cheng Weng, Charles Tzu-Chi Lee, Yi-Lung Chen, Min-Jing Lee
    Neuropsychiatric Disease and Treatment.2020; Volume 16: 1249.     CrossRef
  • Risk of ankylosing spondylitis following human papillomavirus infection: A nationwide, population-based, cohort study
    Chen-Yu Wei, Jia-Ying Lin, Yi-Ting Wang, Jing-Yang Huang, James Cheng-Chung Wei, Jeng-Yuan Chiou
    Journal of Autoimmunity.2020; 113: 102482.     CrossRef
  • Decreased Risk of Influenza in Child and Adolescent Patients with Attention-Deficit Hyperactivity Disorder Following Methylphenidate Treatment: A Nationwide Cohort Study in Taiwan


    Hsuan Lee, Vincent Chin-Hung Chen, Yao-Hsu Yang, Ting-Yu Kuo, Tzu-Chin Lin, Shu-I Wu, Kai-Liang Kao, Jun-Cheng Weng, Brent Allan Kelsen, Sophie Hsin-Yi Liang
    Neuropsychiatric Disease and Treatment.2020; Volume 16: 1309.     CrossRef
  • Creating the BELgian COngenital heart disease database combining administrative and clinical data (BELCODAC): Rationale, design and methodology
    Fouke Ombelet, Eva Goossens, Ruben Willems, Lieven Annemans, Werner Budts, Julie De Backer, Katya De Groote, Stéphane Moniotte, Liesbet Van Bulck, Ariane Marelli, Philip Moons
    International Journal of Cardiology.2020; 316: 72.     CrossRef
  • The Trend of Aggressive Treatments in End-of-Life Care for Older People With Dementia After a Policy Change in Taiwan
    Ying Hsin Hsu, Ming Yueh Chou, Hsiu-Min Chen, Wei-Cheng Chang, Che Sheng Chu, Yu-Chun Wang, Chiao-Lin Hsu, Chih-Kuang Liang, Ching-Chih Lee, Yu Te Lin
    Journal of the American Medical Directors Association.2020; 21(6): 858.     CrossRef
  • Relationship between Helicobacter pylori infection and psoriasis: a nationwide population-based longitudinal cohort study
    Meng-Che Wu, Kevin Sheng-Kai Ma, Huang-Hsi Chen, Jing-Yang Huang, James Cheng-Chung Wei
    Medicine.2020; 99(24): e20632.     CrossRef
  • Association between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study
    Yi-Ju Chen, Chao-Kuei Juan, Yun-Ting Chang, Chun-Ying Wu, Hsiu J. Ho, Hsiao-Ching Tseng
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  • Prescription patterns and factors influencing the use of Chinese herbal medicine among pregnant women in Taiwan: a population-based retrospective study
    Shu-Hui Wen, Wei-Chuan Chang, Hsuan-Shu Shen, Hsien-Chang Wu
    BMC Complementary Medicine and Therapies.2020;[Epub]     CrossRef
  • Chinese Herbal Medicine Is Helpful for Survival Improvement in Patients With Multiple Myeloma in Taiwan: A Nationwide Retrospective Matched-Cohort Study
    Chia-Yu Huang, Mei-Yao Wu, Yu-Hung Kuo, Sio-Ian Tou, Hung-Rong Yen
    Integrative Cancer Therapies.2020;[Epub]     CrossRef
  • Green space structures and schizophrenia incidence in Taiwan: is there an association?
    Hao-Ting Chang, Chih-Da Wu, Jung-Der Wang, Po-See Chen, Ying-Jan Wang, Huey-Jen Su
    Environmental Research Letters.2020; 15(9): 094058.     CrossRef
  • Liver cancer prediction in a viral hepatitis cohort: A deep learning approach
    Dinh‐Van Phan, Chien‐Lung Chan, Ai‐Hsien Adams Li, Ting‐Ying Chien, Van‐Chuc Nguyen
    International Journal of Cancer.2020; 147(10): 2871.     CrossRef
  • Medical Insurance Information Systems in China: Mixed Methods Study
    Yazi Li, Chunji Lu, Yang Liu
    JMIR Medical Informatics.2020; 8(9): e18780.     CrossRef
  • Impact of tonsillectomy on irritable bowel syndrome: A nationwide population-based cohort study
    Meng-Che Wu, Kevin Sheng-Kai Ma, Yu-Hsun Wang, James Cheng-Chung Wei, Sanjiv Mahadeva
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  • Challenges faced in managing adult asthma: A perspective from Asian countries
    Raja Dhar, Mary Ip, Tarang Kulkarni, Sang‐Heon Kim, Diahn‐Warng Perng, Xin Yao, Takashi Iwanaga, Mariko Siyue Koh
    Respirology.2020; 25(12): 1235.     CrossRef
  • Impact of Liver Cirrhosis on Incidence of Dialysis Among Patients with Type 2 Diabetes
    Yi-Jing Sheen, Pei-Tseng Kung, Wayne H.-H. Sheu, Wei-Yin Kuo, Wen-Chen Tsai
    Diabetes Therapy.2020; 11(11): 2611.     CrossRef
  • Association of Infections and Use of Fluoroquinolones With the Risk of Aortic Aneurysm or Aortic Dissection
    Yaa-Hui Dong, Chia-Hsuin Chang, Jiun-Ling Wang, Li-Chiu Wu, Jou-Wei Lin, Sengwee Toh
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  • Association of ocular diseases with schizophrenia, bipolar disorder, and major depressive disorder: a retrospective case-control, population-based study
    Chun-Hao Liu, Eugene Yu-Chuan Kang, Yu-Hsiang Lin, Wei-Chi Wu, Zhuo-Hao Liu, Chang-Fu Kuo, Chi-Chun Lai, Yih-Shiou Hwang
    BMC Psychiatry.2020;[Epub]     CrossRef
  • Constipation might be associated with risk of allergic rhinitis: A nationwide population-based cohort study
    Meng-Che Wu, Ming-Shiou Jan, Jeng-Yuan Chiou, Yu-Hsun Wang, James Cheng-Chung Wei, Tomohiko Ai
    PLOS ONE.2020; 15(10): e0239723.     CrossRef
  • Economic burden of cancers in Taiwan: a direct and indirect cost estimate for 2007–2017
    Shao-Yi Huang, Ho-Min Chen, Kai-Hsin Liao, Bor-Sheng Ko, Fei-Yuan Hsiao
    BMJ Open.2020; 10(10): e036341.     CrossRef
  • Uremic pruritus and long-term morbidities in the dialysis population
    Sze-Wen Ting, Pei-Chun Fan, Yu-Sheng Lin, Ming-Shyan Lin, Cheng-Chia Lee, George Kuo, Chih-Hsiang Chang, Yu Ru Kou
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  • Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study
    Liang-Yu Chen, Huey-Juan Lin, Wen-Tung Wu, Yong-Chen Chen, Cheng-Li Chen, Jing Kao, San-Lin You, Yu-Ching Chou, Chien-An Sun
    International Journal of Environmental Research and Public Health.2020; 17(21): 8271.     CrossRef
  • Association Between Low-Dose Aspirin Use and Colorectal Cancer Incidence in Taiwan
    Hui-Min Diana Lin, Pareen Vora, Montse Soriano-Gabarró, K. Arnold Chan
    JAMA Network Open.2020; 3(11): e2026494.     CrossRef
  • Effects of Erythropoietin Payment Policy on Cardiovascular Outcomes of Peritoneal Dialysis Patients: Observational Study
    Ying-Hui Hou, Feng-Jung Yang, I-Chun Lai, Shih-Pi Lin, Thomas TH Wan, Ray-E Chang
    JMIR Medical Informatics.2020; 8(12): e18716.     CrossRef
  • Hysterectomies are associated with an increased risk of osteoporosis and bone fracture: A population-based cohort study
    Ying-Ting Yeh, Pei-Chen Li, Kun-Chi Wu, Yu-Cih Yang, Weishan Chen, Hei-Tung Yip, Jen-Hung Wang, Shinn-Zong Lin, Dah-Ching Ding, Yu Ru Kou
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  • Outcomes after surgery in patients with diabetes who used metformin: a retrospective cohort study based on a real-world database
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    BMJ Open Diabetes Research & Care.2020; 8(2): e001351.     CrossRef
  • Risk of Leukemia after Dengue Virus Infection: A Population-Based Cohort Study
    Yu-Wen Chien, Chia-Chun Wang, Yu-Ping Wang, Cho-Yin Lee, Guey Chuen Perng
    Cancer Epidemiology, Biomarkers & Prevention.2020; 29(3): 558.     CrossRef
  • Big Data in Ophthalmology
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    Asia-Pacific Journal of Ophthalmology.2020; 9(4): 291.     CrossRef
  • Apolipoprotein B Level and the Apolipoprotein B/Apolipoprotein A-I Ratio as a Harbinger of Ischemic Stroke: A Prospective Observation in Taiwan
    Yu-Ching Chou, Po-Chi Chan, Tsan Yang, San-Lin You, Chyi-Huey Bai, Chien-An Sun
    Cerebrovascular Diseases.2020; 49(5): 487.     CrossRef
  • Risk of Dementia in Diabetic Patients with Hyperglycemic Crisis: A Nationwide Taiwanese Population-Based Cohort Study
    Chih-Ho Chou, I-Jung Feng, Yi-Chen Chen, Jiann-Hwa Chen, Hung-Jung Lin, Jhi-Joung Wang, Chien-Chin Hsu, Chien-Cheng Huang
    Neuroepidemiology.2020; 54(5): 419.     CrossRef
  • Incidence and risk of major adverse cardiovascular events in middle-aged patients with chronic kidney disease: a population-based cohort study
    Shiauyee Chen, Wen-yen Hsu, Yen-Nung Lin, Chien-Yung Wang, Chien-Hua Wu, Kwang-Hwa Chang
    International Urology and Nephrology.2019; 51(7): 1219.     CrossRef
  • Dental treatment procedures for periodontal disease and the subsequent risk of ischaemic stroke: A retrospective population‐based cohort study
    Hsiao‐Wei Lin, Chun‐Min Chen, Yi‐Chun Yeh, Yen‐Yu Chen, Ru‐Yu Guo, Yen‐Ping Lin, Ya‐Ching Li
    Journal of Clinical Periodontology.2019; 46(6): 642.     CrossRef
  • Risk of schizophrenia among people with obsessive-compulsive disorder: A nationwide population-based cohort study
    Yu-Fang Cheng, Vincent Chin-Hung Chen, Yao-Hsu Yang, Ko-Jung Chen, Yi-Chen Lee, Mong-Liang Lu
    Schizophrenia Research.2019; 209: 58.     CrossRef
  • Use of Antiplatelet Agents and Survival of Tuberculosis Patients: A Population-Based Cohort Study
    Meng-Rui Lee, Ming-Chia Lee, Chia-Hao Chang, Chia-Jung Liu, Lih-Yu Chang, Jun-Fu Zhang, Jann-Yuan Wang, Chih-Hsin Lee
    Journal of Clinical Medicine.2019; 8(7): 923.     CrossRef
  • Statin use and Vital Organ Failure in Patients With Asthma–Chronic Obstructive Pulmonary Disease Overlap: A Time-Dependent Population-Based Study
    Jun-Jun Yeh, Shih-Huei Syue, Cheng-Li Lin, Chung Y. Hsu, Zonyin Shae, Chia-Hung Kao
    Frontiers in Pharmacology.2019;[Epub]     CrossRef
  • Health care utilization pattern prior to maltreatment among children under five years of age in Taiwan
    Liang-Yi Wang, Chih-Ying Wu, Yi-Hsin Chang, Tsung-Hsueh Lu
    Child Abuse & Neglect.2019; 98: 104202.     CrossRef
  • Insulin enhances and metformin reduces risk of colorectal carcinoma in type-2 diabetes
    C-H Chen, C-L Lin, C-Y Hsu, C-H Kao
    QJM: An International Journal of Medicine.2019;[Epub]     CrossRef
  • Association of gout medications and risk of cataract: a population-based case–control study
    Y-J Li, W-T Perng, K-Y Tseng, Y-H Wang, J C-C Wei
    QJM: An International Journal of Medicine.2019; 112(11): 841.     CrossRef
  • High risk of gastrointestinal hemorrhage in patients with systemic sclerosis
    Yi-Ting Lin, Yun-Shiuan Chuang, Jiunn-Wei Wang, Ping-Hsun Wu
    Arthritis Research & Therapy.2019;[Epub]     CrossRef
  • Herbal Medicine Containing Aristolochic Acid and the Risk of Primary Liver Cancer in Patients with Hepatitis C Virus Infection
    Chi-Jen Chen, Yao-Hsu Yang, Meng-Hung Lin, Chuan-Pin Lee, Yu-Tse Tsan, Ming-Nan Lai, Hsiao-Yu Yang, Pat Doyle, Wen-Chao Ho, Pau-Chung Chen
    Cancer Epidemiology, Biomarkers & Prevention.2019; 28(11): 1876.     CrossRef

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