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- Original article Association of decreased estimated glomerular filtration rate with lung cancer risk in the Korean population
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Soonsu Shin1,2
, Min-Ho Kim3
, Chang-Mo Oh4
, Hyejin Chun5
, Eunhee Ha6
, Hyo Choon Lee2
, Seong Ho Moon2
, Dong-Young Lee7
, Dosang Cho8
, Sangho Lee9
, Min Hyung Jung10
, Jae-Hong Ryoo11
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Epidemiol Health 2024;e2024041
DOI: https://doi.org/10.4178/epih.e2024041 [Accepted]
Published online: March 20, 2024
2Department of Occupational and Environmental Medicine, Kyung Hee University Hospital, Seoul, Korea
3Ewha Medical Data Organization, Ewha Womans University Seoul Hospital , Seoul, Korea
4Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea
5Department of Family Medicine, College of Medicine, Ewha Womans University, Seoul, Korea
6Department of Occupational and Environment Medicine, College of Medicine, Ewha Womans University, Seoul, Korea
7Department of Internal Medicine, Veterans Healthcare Service Medical Center, Seoul, Korea
8Department of Neurosurgery, Ewha Womans University Seoul Hospital, Seoul, Korea
9Department of Anesthesiology and Pain Medicine, Kyung Hee University Medical Center, Seoul, Korea
10Department of Obstetrics and Gynecology, Kyung Hee University Hospital, Seoul, Korea
11Department of Occupational and Environmental Medicine, School of Medicine, Kyung Hee University, Seoul, Korea
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Corresponding author:
Jae-Hong Ryoo,
Email: armani131@naver.com
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Abstract
OBJECTIVES
Inconsistent results are available regarding the association between low estimated glomerular filtration rate (eGFR) and lung cancer risk. We aimed to explore the risk of lung cancer according to eGFR category in the Korean population.
METHODS
We included 358,293 adults who underwent health checkups between 2009 and 2010, utilizing data from the National Health Insurance Service-National Sample Cohort. Participants were categorized into 3 groups based on their baseline eGFR, as determined using the Chronic Kidney Disease Epidemiology Collaboration equation: group 1 (eGFR ≥90 mL/min/1.73m2), group 2 (eGFR ≥60 to <90mL/min/1.73m2), and group 3 (eGFR <60 mL/min/1.73m2). Incidences of lung cancer were identified using the corresponding codes from the International Classification of Diseases, 10th Revision. Multivariate Cox proportional hazard models were employed to calculate the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for lung cancer incidence up to 2019.
RESULTS
In multivariate analysis, group 2 exhibited a 26.5% higher risk of developing lung cancer than group 1 (HR, 1.265; 95% CI, 1.189 to 1.346). Furthermore, group 3 demonstrated a 72.5% elevated risk of lung cancer relative to group 1 (HR, 1.725; 95% CI, 1.577 to 1.887). Among participants with dipstick proteinuria of 2+ or greater, group 3 faced a significantly higher risk of lung cancer than group 1 (HR, 2.928; 95% CI, 1.375 to 6.237).
CONCLUSION
Low eGFR was significantly associated with increased lung cancer risk within the Korean population. A particularly robust association was observed in individuals with severe proteinuria, emphasizing the need for further investigation.
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