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Korean J Epidemiol > Volume 30(2);2008 > Article
Korean Journal of Epidemiology 2008;30(2): 206-215. doi: http://dx.doi.org/10.4178/kje.2008.30.2.206
Relationship between serum gamma-glutamyltransferase and metabolic syndrome among Korean non-diabetic adults.
Wee Hyun Park, Shung Chull Chae, Byung Yeol Chun, Kyung Eun Lee, Bo Wan Kim, Jung Guk Kim, Ji Seun Lim, Sun Kyun Park
1Cardiovascular Research Institute, Kyungpook NationalUniversity, Korea.
2Health Promotion Research Center, Kyungpook NationalUniversity, Korea. bychun@knu.ac.kr
3Department of Internal Medicine, School of Medicine,Kyungpook National University, Korea.
4Department of Occupational Medicine, Kyungpook NationalUniversity Hospital, Korea.
5Department of Preventive Medicine, School of Medicine,Kyungpook National University, Korea.
Received: 10 October 2008;  Accepted: 18 December 2008.  Published online: 31 December 2008.
ABSTRACT
PURPOSE:
This study was conducted to investigate the association of gamma-glutamyltransferase (GGT) with metabolic syndrome among non-diabetic adults.
METHODS:
This study was conducted in a rural area, South Korea from August, 2003 to November, 2003. The study subjects were 1,023 sampled persons aged from 40 years and older (male 377, female 646). We analyzed the association between GGT with metabolic syndrome by multiple logistic regression analysis using SAS 9.1 version.
RESULTS:
The prevalence of metabolic syndrome in this study was 28.8%. The prevalence of metabolic syndrome was increased by quartiles of serum GGT level (P for trend <0.05). The prevalence of metabolic alterations fitting the criteria of the metabolic syndrome by quartiles of serum GGT level were almost significantly increased except for the criterion of low high density lipoprotein (HDL) cholesterol with adjustment for age and alcohol intake. Among 5 components of metabolic syndrome, the criterion of high serum triglyceride was most powerfully associated with serum GGT level in both gender.
CONCLUSIONS:
This study shows that serum GGT level was significantly associated with metabolic syndrome even after excluding diabetic adults.
KEY WORDS: Gamma-glutamyltransferase; Metabolic Syndrome X; Oxidative Stress; Diabetes Mellitus
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