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MERS
Editorial
2015 MERS outbreak in Korea: hospital-to-hospital transmission
Moran Ki
Epidemiol Health 2015;37:e2015033.
DOI: https://doi.org/10.4178/epih/e2015033
Published online: July 21, 2015

Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea

Correspondence: Moran Ki Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 410-769, Korea Tel: +82-31-920-2736, Fax: +82-50-4069-4908, E-mail: moranki@naver.com
• Received: July 14, 2015   • Accepted: July 21, 2015

©2015, Korean Society of Epidemiology

This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • The distinct characteristic of the Middle East Respiratory Syndrome (MERS) outbreak in South Korea is that it not only involves intra-hospital transmission, but it also involves hospital-to-hospital transmission. It has been the largest MERS outbreak outside the Middle East, with 186 confirmed cases and, among them, 36 fatal cases as of July 26, 2015. All confirmed cases are suspected to be hospital-acquired infections except one case of household transmission and two cases still undergoing examination. The Korean health care system has been the major factor shaping the unique characteristics of the outbreak. Taking this as an opportunity, the Korean government should carefully assess the fundamental problems of the vulnerability to hospital infection and make short- as well as long-term plans for countermeasures. In addition, it is hoped that this journal, Epidemiology and Health, becomes a place where various topics regarding MERS can be discussed and shared.
The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an RNA virus in the family of Coronaviridae, which was first reported in Saudi Arabia [1]. Information on the mode of transmission of the virus remains limited at the moment. Furthermore, there is no effective medication or vaccine against MERS, and it shows a high case fatality rate of 40% [2-4].
It was May 20, 2015 when the first MERS patient was confirmed in Korea. As of July 26, within approximately two months, 186 cases have been confirmed, including 36 deaths and 138 completely recovered cases. Among the remaining 12 patients still under treatment, 9 are in stable condition but 3 are unstable. Currently, there are only one person in quarantine, and 16,692 people have been released [5]. Hospital-to-hospital transmission occurred in 17 hospitals, all of which originated in one hospital.
Characteristics of confirmed cases
Out of the 186 confirmed cases as of July 26, 2015, 111 were male and 75 were female, and the confirmed cases occurred most in those in their 50s among males and in those in their 60s among females. One male patient was in the 10 to 19 age range. Out of 186 confirmed cases reported, 28 were first generation cases (15.1%) infected by the index case, 125 second generation cases (67.2%), and 32 third generation cases (17.2%). In two additional cases, the modes of infection are not certain yet. There are 82 cases (44%) who were admitted (or treated) in the same hospital with a confirmed case, 71 cases (38%) who are family members, health care aides, or visitors, and 31 cases (17%) who are medical staff.
The number of confirmed cases associated with each hospital that has been affected by the outbreak are as follows: 36 cases (19.4%) originated at Pyeongtaek St. Mary’s Hospital where the outbreak was started by the index case, 91 cases (48.9%) at Samsung Medical Center by the 14th confirmed case who was infected at Pyeongtaek St. Mary’s Hospital, and 25 cases (13.4%) at Daecheong Hospital and Konyang University Hospital by the 16th confirmed case who was also infected at Pyeongtaek St. Mary’s Hospital. Furthermore, 11 cases (5.9%) at KunKuk University Medical Center, Kyung Hee University Hospital and ambulance are quaternary cases who were infected by the 76th confirmed case, who was infected at Samsung Medical Center by the 14th confirmed case. Twenty additional cases were distributed among 11 other hospitals or ambulance (Figure 1).
Among the confirmed cases, 77 patients (41%) had underlying diseases, and the most common initial symptoms included fever (93.5%), followed by cough (41.4%), myalgia (25.9%), sputum (18.8%), diarrhea (11.8%), shortness of breath (7.5%), and nausea and vomiting (7.5%).
Characteristics of deaths
Up until July 26, 36 cases had died out of 186, marking a case fatality rate of 19.4.%, but when the 12 cases under treatment are excluded from denominator, the case fatality rate becomes 20.7%. The case fatality rate was 29.3% among patients, 15.5% among family members, health care aides, or visitors, and 3.2% among medical staff. Among the medical staff, the death case was a 70 years old male driver of an ambulance. The case fatality rate was 21.6% among males, 16.0% among females, 77.8% among those in their 80s or beyond, 36.7% in those in their 70s, 30.6% in those in their 60s, 14.6% in those in their 50s, and 3.3% in patients in their 40s. Out of 77 patients with underlying diseases, 26 patients (33.8%) died, and out of 109 patients without underlying diseases, 10 patients (9.2%) died.
Epidemiological characteristics
The incubation period, that is, the duration from the midpoint of the exposure to the symptom onset, was 6.5 days (median; range, 2 to 16 days). The median time from symptom onset to confirmation was 5 days (0 to 17 days), that from symptom onset to death was 13 days (1 to 41 days), and that from symptom onset to discharge from the hospital was 20 days (8 to 41 days).
Characteristics of the outbreak
The MERS outbreak in Korea can be characterized by intra-hospital transmission as well as hospital-to-hospital transmission due to movement of cases from one hospital to another. Out of 186 cases, the majority are hospital-acquired infections: Only one patient is suspected of household transmission, and for two patients, the modes of transmission are still under examination. Among the latter two, one case is suspected to have been a community acquired infection by an unknown route. Specifically, the 1st generation cases infected by the index case, the 2nd generation cases infected by three of the 1st generation cases, and the 3rd generation cases infected by one of the 2nd generation cases comprise 87.6% of the total confirmed cases. This is similar to the main mode of transmission of the patients reported in Saudi Arabia in 2014, which involved super-spreaders and nosocomial transmission [6]. Specifically, the majority of people who transmitted the infection to many other people had close contact with the patients at the hospital after their pneumonia had progressed [7].
Based on this fact, the most important intervention for preventing the spread of the disease is to identify patients who show initial symptoms early on and to provide treatment in isolation before they progress to a severe status.
Causes of the outbreak
The large-scale infection of MERS in Korea is due to intra-hospital infection as well as hospital-to-hospital transmission. The reason that the MERS-infected patients at the Pyeongtaek St. Mary’s Hospital were not controlled and they could visit many different hospitals is because when the index case was confirmed on May 20, the people considered to be close contacts who needed to be quarantined were limited only to the patients and the families in the same hospital room and the medical staff who interacted with them. This was noticed only after another confirmed case was identified in another hospital room on May 28. However, this was already after some infected cases moved to other hospitals without having been informed about MERS. The initial criteria for quarantine was limited to only close contacts,—of being within two meters for more than an hour—, and casual contacts, —of being within the contaminated environments from confirmed case—, were not included. However both contacts should be in quarantine based on Korea Centers for Disease Control and Prevention guidelines [8]. In addition, the base causes of the spread of infection by the MERS infected patients as they moved throughout the country are associated with the Korean health care system, which is vulnerable to hospital-acquired infection, as well as with the cultural characteristics of Korea. Specifically, first of all, all Korean citizens are able to receive medical treatment at a relatively low cost through the nationwide health insurance system. However, in order to reduce costs, more than 50% of hospital rooms have more than 4 beds per room, and the family members of the patients are responsible for providing some care for the patients. Thus, hospital rooms are always crowded with patients as well as their families or privately hired health care aides taking care of the patients. Secondly, the Korean health care delivery system is very loose, in that patients themselves can pick and choose the hospitals that they want to visit. In order to visit tertiary general hospital after primary health care, a referral slip by a doctor is required, but one can be directly treated or admitted to tertiary hospitals without the referral slip if a patient visits the emergency room first. Therefore, many patients go directly to the emergency room in order to be treated at large tertiary hospitals. Thirdly, except for drug utilization reviews, which provide a comprehensive review of patients’ prescription and medication data to prevent duplicated drug prescriptions, information regarding patients’ past disease history, response to certain medications, or the results of examinations are not shared between hospitals. Finally, it is a Korean custom to pay a visit to patients in the hospital out of a sense of duty; thus many visitors come to hospitals. This is another factor that causes crowding in hospitals.
Plan for future countermeasures
The current MERS countermeasure plan provides quarantine criteria without considering the differences between hospital-acquired infection and community-acquired infection. While the current revised guideline seems appropriate in the case of community-acquired infection, it is necessary to use broader criteria for quarantine in the case of hospital-acquired infection [9]. The response to new infectious disease cannot always be perfect. However, it is possible to minimize the damage if we do our best to prepare for the situation. The uncontrollable spread of the outbreak due to the failures of initial epidemiologic investigation and preventive measures as well as the characteristics of the Korean health care system have many important implications. Many experts and organizations are proposing various solutions, and the government, after accepting these suggestions, has started to assess of the entire health care system. However, we must address the root cause rather than providing temporary solutions. In addition, a number of varying lines of research will be conducted based on the experience of the MERS outbreak. The journal Epidemiology and Health is planning to create a separate section dedicated to the MERS outbreak so that related studies can be easily accessible and readily available to researchers around the world. We welcome submissions on topics related to MERS.
I would like to thank the epidemiologic investigators, all of the civil servants from the Korea Centers for Disease Control and Prevention, and members of the Korean Society for Preventive Medicine, as well as the members of the Korean Society of Epidemiology for their dedicated efforts in investigation of the MERS outbreak and prevention of its spread.

The author has no conflicts of interest to declare for this study.

Supplementary material (Korean version) is available at http://www.e-epih.org/.
Figure 1.
Epidemic curve.
epih-37-e2015033f1.gif

Figure & Data

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    • Core-periphery structure and power imbalance in disaster management networks: a Bayesian approach to interorganizational response to a public health disaster
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      Ji Yoon Baek, Seung Hee Seo, Sooyoung Cho, Jun-Bean Park, Bhumsuk Keam, Shin Hye Yoo, Aesun Shin
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      International Journal of Environmental Research and Public Health.2023; 20(4): 3271.     CrossRef
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    • Immunogenic Epitope-Based Vaccine Prediction from Surface Glycoprotein of MERS-CoV by Deploying Immunoinformatics Approach
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    • The Effect of Epidemic Outbreak on Healthcare Usage: Lessons from the 2015 Middle East Respiratory Syndrome Outbreak in South Korea
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    • The COVID-19 pandemic – How many times were we warned before?
      Naim Mahroum, Isa Seida, Sevval Nil Esirgün, Nicola Luigi Bragazzi
      European Journal of Internal Medicine.2022; 105: 8.     CrossRef
    • Development of virus‐like particles‐based vaccines against coronaviruses
      Chean Yeah Yong, Winnie Pui Pui Liew, Hui Kian Ong, Chit Laa Poh
      Biotechnology Progress.2022;[Epub]     CrossRef
    • A semiparametric Bayesian approach to epidemics, with application to the spread of the coronavirus MERS in South Korea in 2015
      Michael Schweinberger, Rashmi P. Bomiriya, Sergii Babkin
      Journal of Nonparametric Statistics.2022; 34(3): 628.     CrossRef
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      Nayoung Kim, Tae-Young Lee, Hansaem Lee, Jeong-Sun Yang, Kyung-Chang Kim, Joo-Yeon Lee, Hyun-Joo Kim
      Vaccines.2022; 10(11): 1843.     CrossRef
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      Jeongwoo Lee, Jihoon Kim, Incheol Park, Junho Cho, Min Joung Kim, Jin Ho Beom
      Journal of EMS Medicine.2022; 1(1): 23.     CrossRef
    • Human coronavirus spike protein-host receptor recognition
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      Progress in Biophysics and Molecular Biology.2021; 161: 39.     CrossRef
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      The Korean Journal of Internal Medicine.2021; 36(5): 1134.     CrossRef
    • MERS-CoV: epidemiology, molecular dynamics, therapeutics, and future challenges
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      Annals of Clinical Microbiology and Antimicrobials.2021;[Epub]     CrossRef
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      JCI Insight.2021;[Epub]     CrossRef
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      Journal of Infection and Public Health.2020; 13(3): 418.     CrossRef
    • The Effects of Social Determinants on Public Health Emergency Preparedness Mediated by Health Communication: The 2015 MERS Outbreak in South Korea
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      Health Communication.2020; 35(11): 1396.     CrossRef
    • Focus on Middle East respiratory syndrome coronavirus (MERS-CoV)
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    • Burden of Middle East respiratory syndrome coronavirus infection in Saudi Arabia
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      Viruses.2020; 12(2): 244.     CrossRef
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    • Psychological and Behavioral Responses in South Korea During the Early Stages of Coronavirus Disease 2019 (COVID-19)
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    • Tackling the COVID-19 Pandemic
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      Archives of Medical Research.2020; 51(5): 468.     CrossRef
    • Complementary and alternative medicine use among outpatients during the 2015 MERS outbreak in South Korea: a cross-sectional study
      Jung Hye Hwang, Hyun Jeong Cho, Hyea Bin Im, Young Sun Jung, Soo Jeung Choi, Dongwoon Han
      BMC Complementary Medicine and Therapies.2020;[Epub]     CrossRef
    • SARS, MERS and COVID-19 among healthcare workers: A narrative review
      Jian Xiao, Min Fang, Qiong Chen, Bixiu He
      Journal of Infection and Public Health.2020; 13(6): 843.     CrossRef
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      Lucia Mullen, Christina Potter, Lawrence O Gostin, Anita Cicero, Jennifer B Nuzzo
      BMJ Global Health.2020; 5(6): e002502.     CrossRef
    • Enhancing hospital event-based surveillance system – Findings from a pilot study, Vietnam, 2017-2018
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      Global Security: Health, Science and Policy.2020; 5(1): 28.     CrossRef
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      International Journal of Molecular Medicine.2020;[Epub]     CrossRef
    • Increased Pathogenicity and Virulence of Middle East Respiratory Syndrome Coronavirus Clade B In Vitro and In Vivo
      Yanqun Wang, Jing Sun, Xiaobo Li, Airu Zhu, Wenda Guan, De-Qiang Sun, Mian Gan, Xuefeng Niu, Jun Dai, Lu Zhang, Zhaoyong Zhang, Yongxia Shi, Shuxiang Huang, Chris Ka Pun Mok, Zifeng Yang, Zhongfang Wang, Wenjie Tan, Yimin Li, Ling Chen, Rongchang Chen, Ma
      Journal of Virology.2020;[Epub]     CrossRef
    • Vaccines based on virus-like nano-particles for use against Middle East Respiratory Syndrome (MERS) coronavirus
      Alireza Hashemzadeh, Amir Avan, Gordon A. Ferns, Majid Khazaei
      Vaccine.2020; 38(36): 5742.     CrossRef
    • A Canary in a COVID Coal Mine: Building Better Healthcare Biopreparedness Policy
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      World Medical & Health Policy.2020; 12(3): 223.     CrossRef
    • Newly Emerging Human Coronaviruses: Animal Models and Vaccine Research for SARS, MERS, and COVID-19
      Pureum Lee, Doo-Jin Kim
      Immune Network.2020;[Epub]     CrossRef
    • Epidemiological parameters of COVID-19 and its implication for infectivity among patients in China, 1 January to 11 February 2020
      Qing-Bin Lu, Yong Zhang, Ming-Jin Liu, Hai-Yang Zhang, Neda Jalali, An-Ran Zhang, Jia-Chen Li, Han Zhao, Qian-Qian Song, Tian-Shuo Zhao, Jing Zhao, Han-Yu Liu, Juan Du, Ai-Ying Teng, Zi-Wei Zhou, Shi-Xia Zhou, Tian-Le Che, Tao Wang, Tong Yang, Xiu-Gang Gu
      Eurosurveillance.2020;[Epub]     CrossRef
    • Learning before and during the COVID-19 outbreak: a comparative analysis of crisis learning in South Korea and the US
      Seulki Lee, Jungwon Yeo, Chongmin Na
      International Review of Public Administration.2020; 25(4): 243.     CrossRef
    • Roadblocks to Infection Prevention Efforts in Health Care: SARS-CoV-2/COVID-19 Response
      Saskia Popescu
      Disaster Medicine and Public Health Preparedness.2020; 14(4): 538.     CrossRef
    • COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far
      Mujeeb Khan, Syed F. Adil, Hamad Z. Alkhathlan, Muhammad N. Tahir, Sadia Saif, Merajuddin Khan, Shams T. Khan
      Molecules.2020; 26(1): 39.     CrossRef
    • Healthcare-associated infections: the hallmark of Middle East respiratory syndrome coronavirus with review of the literature
      J.A. Al-Tawfiq, P.G. Auwaerter
      Journal of Hospital Infection.2019; 101(1): 20.     CrossRef
    • Surveillance and public health response for travelers returning from MERS-CoV affected countries to Gyeonggi Province, Korea, 2016–2017
      Sukhyun Ryu, Joon Jai Kim, Benjamin J. Cowling, Chulhee Kim
      Travel Medicine and Infectious Disease.2019; 31: 101350.     CrossRef
    • Knowledge, perception, performance, and attitude regarding hand hygiene and related factors among infection control nurses in South Korea: A cross-sectional study
      Hyang Soon Oh
      American Journal of Infection Control.2019; 47(3): 258.     CrossRef
    • Clinical and Laboratory Findings of Middle East Respiratory Syndrome Coronavirus Infection
      Se-Min Hwang, Baeg-Ju Na, Yoomi Jung, Hyun-Suk Lim, Jeong-Eun Seo, Shin-Ae Park, Young-Soo Cho, Eun-Hyang Song, Ji-Yeon Seo, Sung-Ryul Kim, Gang-Young Lee, Soon-Ja Kim, Young-Suk Park, Haesook Seo
      Japanese Journal of Infectious Diseases.2019; 72(3): 160.     CrossRef
    • Individual and network characteristic associated with hospital-acquired Middle East Respiratory Syndrome coronavirus
      Oyelola Adegboye, Timor Saffary, Majeed Adegboye, Faiz Elfaki
      Journal of Infection and Public Health.2019; 12(3): 343.     CrossRef
    • Registered nurses are at increased risk of hospitalization for infectious diseases and perinatal complications: A population-based observational study
      Kuei-Lin Liao, Yu-Tung Huang, Shih-Hsien Kuo, Wei-Ting Lin, Fan-Hao Chou, Pi-Ling Chou
      International Journal of Nursing Studies.2019; 91: 70.     CrossRef
    • Airflow analysis of Pyeongtaek St Mary's Hospital during hospitalization of the first Middle East respiratory syndrome patient in Korea
      Seongmin Jo, Jinkwan Hong, Sang-Eun Lee, Moran Ki, Bo Youl Choi, Minki Sung
      Royal Society Open Science.2019; 6(3): 181164.     CrossRef
    • Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017
      Sibylle Bernard-Stoecklin, Birgit Nikolay, Abdullah Assiri, Abdul Aziz Bin Saeed, Peter Karim Ben Embarek, Hassan El Bushra, Moran Ki, Mamunur Rahman Malik, Arnaud Fontanet, Simon Cauchemez, Maria D. Van Kerkhove
      Scientific Reports.2019;[Epub]     CrossRef
    • New and emerging infectious diseases (Ebola, Middle Eastern respiratory syndrome coronavirus, carbapenem-resistant Enterobacteriaceae, Candida auris): Focus on environmental survival and germicide susceptibility
      David J. Weber, Emily E. Sickbert-Bennett, Hajime Kanamori, William A. Rutala
      American Journal of Infection Control.2019; 47: A29.     CrossRef
    • Overview of Current Therapeutics and Novel Candidates Against Influenza, Respiratory Syncytial Virus, and Middle East Respiratory Syndrome Coronavirus Infections
      Mohammad Amin Behzadi, Victor H. Leyva-Grado
      Frontiers in Microbiology.2019;[Epub]     CrossRef
    • Worldwide Reduction in MERS Cases and Deaths since 2016
      Christl A. Donnelly, Mamun R. Malik, Amgad Elkholy, Simon Cauchemez, Maria D. Van Kerkhove
      Emerging Infectious Diseases.2019; 25(9): 1758.     CrossRef
    • Generation and characterization of a monoclonal antibody against MERS-CoV targeting the spike protein using a synthetic peptide epitope-CpG-DNA-liposome complex
      Byoung Kwon Park, Sony Maharjan, Su In Lee, Jinsoo Kim, Joon-Yong Bae, Man-Seong Park, Hyung-Joo Kwon
      BMB Reports.2019; 52(6): 397.     CrossRef
    • Risk Factors for Fatal Middle East Respiratory Syndrome Coronavirus Infections in Saudi Arabia: Analysis of the WHO Line List, 2013–2018
      Arifur Rahman, Atanu Sarkar
      American Journal of Public Health.2019; 109(9): 1288.     CrossRef
    • Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015
      Maria D. Van Kerkhove, Sadoof Alaswad, Abdullah Assiri, Ranawaka A.P.M. Perera, Malik Peiris, Hassan E. El Bushra, Abdulaziz A. BinSaeed
      Emerging Infectious Diseases.2019; 25(10): 1802.     CrossRef
    • Middle East respiratory syndrome coronavirus-encoded ORF8b strongly antagonizes IFN-β promoter activation: its implication for vaccine design
      Jeong Yoon Lee, Sojung Bae, Jinjong Myoung
      Journal of Microbiology.2019; 57(9): 803.     CrossRef
    • Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD
      Nianshuang Wang, Osnat Rosen, Lingshu Wang, Hannah L. Turner, Laura J. Stevens, Kizzmekia S. Corbett, Charles A. Bowman, Jesper Pallesen, Wei Shi, Yi Zhang, Kwanyee Leung, Robert N. Kirchdoerfer, Michelle M. Becker, Mark R. Denison, James D. Chappell, And
      Cell Reports.2019; 28(13): 3395.     CrossRef
    • A Novel Bacterium-Like Particle Vaccine Displaying the MERS-CoV Receptor-Binding Domain Induces Specific Mucosal and Systemic Immune Responses in Mice
      Li, Chi, Huang, Yan, Zhang, Liu, Wang, Li, Zhang, Mo, Jin, Wang, Feng, Wang, Bi, Wang, Sun, Gao, Zhao, Yang, Xia
      Viruses.2019; 11(9): 799.     CrossRef
    • Risk of transmission via medical employees and importance of routine infection-prevention policy in a nosocomial outbreak of Middle East respiratory syndrome (MERS): a descriptive analysis from a tertiary care hospital in South Korea
      Hyun Kyun Ki, Sang Kuk Han, Jun Seong Son, Sang O Park
      BMC Pulmonary Medicine.2019;[Epub]     CrossRef
    • Identifying potential emerging threats through epidemic intelligence activities—looking for the needle in the haystack?
      Jennifer Wilburn, Catherine O’Connor, Amanda L. Walsh, Dilys Morgan
      International Journal of Infectious Diseases.2019; 89: 146.     CrossRef
    • Optimal Resource Allocation over Complex Networks: An Approach via Geometric Programming
      Masaki OGURA
      IEICE ESS Fundamentals Review.2019; 12(3): 191.     CrossRef
    • Association between Hospital Nurses’ Perception of Patient Safety Management and Standard Precaution Adherence: A Cross-Sectional Study
      Ji-Hye Lim, Jung-Won Ahn, Youn-Jung Son
      International Journal of Environmental Research and Public Health.2019; 16(23): 4744.     CrossRef
    • Gender Difference in the Effects of Outdoor Air Pollution on Cognitive Function Among Elderly in Korea
      Hyunmin Kim, Juhwan Noh, Young Noh, Sung Soo Oh, Sang-Baek Koh, Changsoo Kim
      Frontiers in Public Health.2019;[Epub]     CrossRef
    • A database of geopositioned Middle East Respiratory Syndrome Coronavirus occurrences
      Rebecca E. Ramshaw, Ian D. Letourneau, Amy Y. Hong, Julia Hon, Julia D. Morgan, Joshua C. P. Osborne, Shreya Shirude, Maria D. Van Kerkhove, Simon I. Hay, David M. Pigott
      Scientific Data.2019;[Epub]     CrossRef
    • A Comparative Analysis of Factors Influencing Two Outbreaks of Middle Eastern Respiratory Syndrome (MERS) in Saudi Arabia and South Korea
      Marnie Willman, Darwyn Kobasa, Jason Kindrachuk
      Viruses.2019; 11(12): 1119.     CrossRef
    • MERS-CoV infection in South Korea and strategies for possible future outbreak: narrative review
      Chulwoo Park
      Journal of Global Health Reports.2019;[Epub]     CrossRef
    • A Review of Asymptomatic and Subclinical Middle East Respiratory Syndrome Coronavirus Infections
      Rebecca Grant, Mamunur Rahman Malik, Amgad Elkholy, Maria D Van Kerkhove
      Epidemiologic Reviews.2019; 41(1): 69.     CrossRef
    • A Case Study Evaluating the Risk of Infection from Middle Eastern Respiratory Syndrome Coronavirus (MERS‐CoV) in a Hospital Setting Through Bioaerosols
      Umesh Adhikari, Alexandre Chabrelie, Mark Weir, Kevin Boehnke, Erica McKenzie, Luisa Ikner, Meng Wang, Qing Wang, Kyana Young, Charles N. Haas, Joan Rose, Jade Mitchell
      Risk Analysis.2019; 39(12): 2608.     CrossRef
    • MERS-CoV infection: Mind the public knowledge gap
      Amen Bawazir, Eman Al-Mazroo, Hoda Jradi, Anwar Ahmed, Motasim Badri
      Journal of Infection and Public Health.2018; 11(1): 89.     CrossRef
    • High reproduction number of Middle East respiratory syndrome coronavirus in nosocomial outbreaks: mathematical modelling in Saudi Arabia and South Korea
      S. Choi, E. Jung, B.Y. Choi, Y.J. Hur, M. Ki
      Journal of Hospital Infection.2018; 99(2): 162.     CrossRef
    • A Middle East respiratory syndrome screening clinic for health care personnel during the 2015 Middle East respiratory syndrome outbreak in South Korea: A single-center experience
      Ji Yeon Lee, Gayeon Kim, Dong-Gyun Lim, Hyeon-Gun Jee, Yunyoung Jang, Joon-Sung Joh, Ina Jeong, Yeonjae Kim, Eunhee Kim, Bum Sik Chin
      American Journal of Infection Control.2018; 46(4): 436.     CrossRef
    • Role of viral bioaerosols in nosocomial infections and measures for prevention and control
      Bing-Yuan, Yun-Hui Zhang, Nancy H.L. Leung, Benjamin J. Cowling, Zi-Feng Yang
      Journal of Aerosol Science.2018; 117: 200.     CrossRef
    • Provision of oral hygiene services as a potential method for preventing periodontal disease and control hypertension and diabetes in a community health centre in Korea
      Nam-Hee Kim, Ga-Yeong Lee, Su-Kyung Park, Yeun-Ju Kim, Min-Young Lee, Chun-Bae Kim
      Health & Social Care in the Community.2018; 26(3): e378.     CrossRef
    • Measles-derived vaccines to prevent emerging viral diseases
      Phanramphoei N. Frantz, Samaporn Teeravechyan, Frédéric Tangy
      Microbes and Infection.2018; 20(9-10): 493.     CrossRef
    • Middle East respiratory syndrome: what we learned from the 2015 outbreak in the Republic of Korea
      Myoung-don Oh, Wan Beom Park, Sang-Won Park, Pyoeng Gyun Choe, Ji Hwan Bang, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim, Nam Joong Kim
      The Korean Journal of Internal Medicine.2018; 33(2): 233.     CrossRef
    • MERS transmission and risk factors: a systematic review
      Ji-Eun Park, Soyoung Jung, Aeran Kim, Ji-Eun Park
      BMC Public Health.2018;[Epub]     CrossRef
    • Network Analysis of MERS Coronavirus within Households, Communities, and Hospitals to Identify Most Centralized and Super-Spreading in the Arabian Peninsula, 2012 to 2016
      Oyelola A. Adegboye, Faiz Elfaki
      Canadian Journal of Infectious Diseases and Medical Microbiology.2018; 2018: 1.     CrossRef
    • Chaperna-Mediated Assembly of Ferritin-Based Middle East Respiratory Syndrome-Coronavirus Nanoparticles
      Young-Seok Kim, Ahyun Son, Jihoon Kim, Soon Bin Kwon, Myung Hee Kim, Paul Kim, Jieun Kim, Young Ho Byun, Jemin Sung, Jinhee Lee, Ji Eun Yu, Chan Park, Yeon-Sook Kim, Nam-Hyuk Cho, Jun Chang, Baik L. Seong
      Frontiers in Immunology.2018;[Epub]     CrossRef
    • Working experiences of nurses during the Middle East respiratory syndrome outbreak
      Hee Sun Kang, Ye Dong Son, Sun‐Mi Chae, Colleen Corte
      International Journal of Nursing Practice.2018;[Epub]     CrossRef
    • Asymptomatic Middle East Respiratory Syndrome coronavirus infection using a serologic survey in Korea
      Yeong-jun Song, Jeong-Sun Yang, Hee Jung Yoon, Hae-Sung Nam, Soon Young Lee, Hae-Kwan Cheong, Woo-Jung Park, Sung Han Park, Bo Youl Choi, Sung Soon Kim, Moran Ki
      Epidemiology and Health.2018; 40: e2018014.     CrossRef
    • Knowledge, Perceptions, and Self-reported Performance of Hand Hygiene Among Registered Nurses at Community-based Hospitals in the Republic of Korea: A Cross-sectional Multi-center Study
      Hyang Soon Oh
      Journal of Preventive Medicine and Public Health.2018; 51(3): 121.     CrossRef
    • Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016
      A. Bleibtreu, S. Jaureguiberry, N. Houhou, D. Boutolleau, H. Guillot, D. Vallois, J. C. Lucet, J. Robert, B. Mourvillier, J. Delemazure, M. Jaspard, F. X. Lescure, C. Rioux, E. Caumes, Y. Yazdanapanah
      BMC Infectious Diseases.2018;[Epub]     CrossRef
    • Human Mobility and the Global Spread of Infectious Diseases: A Focus on Air Travel
      Aidan Findlater, Isaac I. Bogoch
      Trends in Parasitology.2018; 34(9): 772.     CrossRef
    • Reported Direct and Indirect Contact with Dromedary Camels among Laboratory-Confirmed MERS-CoV Cases
      Romy Conzade, Rebecca Grant, Mamunur Malik, Amgad Elkholy, Mohamed Elhakim, Dalia Samhouri, Peter Ben Embarek, Maria Van Kerkhove
      Viruses.2018; 10(8): 425.     CrossRef
    • MERS: Progress on the global response, remaining challenges and the way forward
      Ryan Aguanno, Ahmed ElIdrissi, Amgad A. Elkholy, Peter Ben Embarek, Emma Gardner, Rebecca Grant, Heba Mahrous, Mamunur Rahman Malik, Gounalan Pavade, Sophie VonDobschuetz, Lidewij Wiersma, Maria D. Van Kerkhove
      Antiviral Research.2018; 159: 35.     CrossRef
    • CD8+ T Cells Responding to the Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Delivered by Vaccinia Virus MVA in Mice
      Svenja Veit, Sylvia Jany, Robert Fux, Gerd Sutter, Asisa Volz
      Viruses.2018; 10(12): 718.     CrossRef
    • Public preferences for interventions to prevent emerging infectious disease threats: a discrete choice experiment
      Alex R Cook, Xiahong Zhao, Mark I C Chen, Eric A Finkelstein
      BMJ Open.2018; 8(2): e017355.     CrossRef
    • Fatality risks for nosocomial outbreaks of Middle East respiratory syndrome coronavirus in the Middle East and South Korea
      Jianping Sha, Yuan Li, Xiaowen Chen, Yan Hu, Yajin Ren, Xingyi Geng, Zhiruo Zhang, Shelan Liu
      Archives of Virology.2017; 162(1): 33.     CrossRef
    • Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications
      K.H. Kim, T.E. Tandi, J.W. Choi, J.M. Moon, M.S. Kim
      Journal of Hospital Infection.2017; 95(2): 207.     CrossRef
    • Human Coronavirus in the 2014 Winter Season as a Cause of Lower Respiratory Tract Infection
      Kyu Yeun Kim, Song Yi Han, Ho-Seong Kim, Hyang-Min Cheong, Sung Soon Kim, Dong Soo Kim
      Yonsei Medical Journal.2017; 58(1): 174.     CrossRef
    • MERS-CoV spike protein: a key target for antivirals
      Lanying Du, Yang Yang, Yusen Zhou, Lu Lu, Fang Li, Shibo Jiang
      Expert Opinion on Therapeutic Targets.2017; 21(2): 131.     CrossRef
    • Middle East Respiratory Syndrome
      Yaseen M. Arabi, Hanan H. Balkhy, Frederick G. Hayden, Abderrezak Bouchama, Thomas Luke, J. Kenneth Baillie, Awad Al-Omari, Ali H. Hajeer, Mikiko Senga, Mark R. Denison, Jonathan S. Nguyen-Van-Tam, Nahoko Shindo, Alison Bermingham, James D. Chappell, Mari
      New England Journal of Medicine.2017; 376(6): 584.     CrossRef
    • Outcome of strict implementation of infection prevention control measures during an outbreak of Middle East respiratory syndrome
      Hassan E. El Bushra, Hussain A. Al Arbash, Mutaz Mohammed, Osman Abdalla, Mohamed N. Abdallah, Zayid K. Al-Mayahi, Abdallah M. Assiri, Abdulaziz A. BinSaeed
      American Journal of Infection Control.2017; 45(5): 502.     CrossRef
    • DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice
      Hang Chi, Xuexing Zheng, Xiwen Wang, Chong Wang, Hualei Wang, Weiwei Gai, Stanley Perlman, Songtao Yang, Jincun Zhao, Xianzhu Xia
      Vaccine.2017; 35(16): 2069.     CrossRef
    • High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea
      Hae-Sung Nam, Jung Wan Park, Moran Ki, Mi-Yeon Yeon, Jin Kim, Seung Woo Kim
      International Journal of Infectious Diseases.2017; 58: 37.     CrossRef
    • Effects of operational decisions on the diffusion of epidemic disease: A system dynamics modeling of the MERS-CoV outbreak in South Korea
      Nina Shin, Taewoo Kwag, Sangwook Park, Yon Hui Kim
      Journal of Theoretical Biology.2017; 421: 39.     CrossRef
    • Hospital Outbreaks of Middle East Respiratory Syndrome, Daejeon, South Korea, 2015
      Jung Wan Park, Keon Joo Lee, Kang Hyoung Lee, Sang Hyup Lee, Jung Rae Cho, Jin Won Mo, Soo Young Choi, Geun Yong Kwon, Ji-Yeon Shin, Jee Young Hong, Jin Kim, Mi-Yeon Yeon, Jong Seok Oh, Hae-Sung Nam
      Emerging Infectious Diseases.2017; 23(6): 898.     CrossRef
    • Zero Transmission of Middle East Respiratory Syndrome: Lessons Learned From Thailand
      Surasak Wiboonchutikul, Weerawat Manosuthi, Chariya Sangsajja
      Clinical Infectious Diseases.2017; 64(suppl_2): S167.     CrossRef
    • A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein
      Yingzhu Chen, Shuai Lu, Hao Jia, Yao Deng, Jianfang Zhou, Baoying Huang, Yueyang Yu, Jiaming Lan, Wenling Wang, Yongliang Lou, Kun Qin, Wenjie Tan
      Emerging Microbes & Infections.2017; 6(1): 1.     CrossRef
    • The clinical and virological features of the first imported case causing MERS-CoV outbreak in South Korea, 2015
      Ji Yeon Lee, You-Jin Kim, Eun Hee Chung, Dae-Won Kim, Ina Jeong, Yeonjae Kim, Mi-ran Yun, Sung Soon Kim, Gayeon Kim, Joon-Sung Joh
      BMC Infectious Diseases.2017;[Epub]     CrossRef
    • Impact of Middle East respiratory syndrome outbreak on the use of emergency medical resources in febrile patients
      Hyunho Jeong, Sikyoung Jeong, Juseok Oh, Seon Hee Woo, Byung Hak So, Jeong Hee Wee, Ji Hoon Kim, Ji Yong Im, Seung Pill Choi, Kyoungnam Park, Byul Nim Hee Cho, Sungyoup Hong
      Clinical and Experimental Emergency Medicine.2017; 4(2): 94.     CrossRef
    • Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
      Jesper Pallesen, Nianshuang Wang, Kizzmekia S. Corbett, Daniel Wrapp, Robert N. Kirchdoerfer, Hannah L. Turner, Christopher A. Cottrell, Michelle M. Becker, Lingshu Wang, Wei Shi, Wing-Pui Kong, Erica L. Andres, Arminja N. Kettenbach, Mark R. Denison, Jam
      Proceedings of the National Academy of Sciences.2017;[Epub]     CrossRef
    • MERS-CoV Infection in a Pregnant Woman in Korea
      Soo Young Jeong, Se In Sung, Ji-Hee Sung, So Yoon Ahn, Eun-Suk Kang, Yun Sil Chang, Won Soon Park, Jong-Hwa Kim
      Journal of Korean Medical Science.2017; 32(10): 1717.     CrossRef
    • The Impact of Middle East Respiratory Syndrome Outbreak on Trends in Emergency Department Utilization Patterns
      So Hyun Paek, Do Kyun Kim, Jin Hee Lee, Young Ho Kwak
      Journal of Korean Medical Science.2017; 32(10): 1576.     CrossRef
    • Exploring Nursing Intention, Stress, and Professionalism in Response to Infectious Disease Emergencies: The Experience of Local Public Hospital Nurses During the 2015 MERS Outbreak in South Korea
      Namhee Oh, NamSoo Hong, Dong Hee Ryu, Sang Geun Bae, Sin Kam, Keon-Yeop Kim
      Asian Nursing Research.2017; 11(3): 230.     CrossRef
    • Critically Ill Patients With the Middle East Respiratory Syndrome: A Multicenter Retrospective Cohort Study
      Yaseen M. Arabi, Awad Al-Omari, Yasser Mandourah, Fahad Al-Hameed, Anees A. Sindi, Basem Alraddadi, Sarah Shalhoub, Abdullah Almotairi, Kasim Al Khatib, Ahmed Abdulmomen, Ismael Qushmaq, Ahmed Mady, Othman Solaiman, Abdulsalam M. Al-Aithan, Rajaa Al-Radda
      Critical Care Medicine.2017; 45(10): 1683.     CrossRef
    • Healthcare worker infected with Middle East Respiratory Syndrome during cardiopulmonary resuscitation in Korea, 2015
      Hae-Sung Nam, Mi-Yeon Yeon, Jung Wan Park, Jee-Young Hong, Ji Woong Son
      Epidemiology and Health.2017; 39: e2017052.     CrossRef
    • Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants
      Wanbo Tai, Yufei Wang, Craig A. Fett, Guangyu Zhao, Fang Li, Stanley Perlman, Shibo Jiang, Yusen Zhou, Lanying Du, Terence S. Dermody
      Journal of Virology.2017;[Epub]     CrossRef
    • CD8 + T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome
      Christopher M. Coleman, Jeanne M. Sisk, Gabor Halasz, Jixin Zhong, Sarah E. Beck, Krystal L. Matthews, Thiagarajan Venkataraman, Sanjay Rajagopalan, Christos A. Kyratsous, Matthew B. Frieman, Julie K. Pfeiffer
      Journal of Virology.2017;[Epub]     CrossRef
    • A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein
      Yingzhu Chen, Shuai Lu, Hao Jia, Yao Deng, Jianfang Zhou, Baoying Huang, Yueyang Yu, Jiaming Lan, Wenling Wang, Yongliang Lou, Kun Qin, Wenjie Tan
      Emerging Microbes & Infections.2017; 6(1): 1.     CrossRef
    • Transmission among healthcare worker contacts with a Middle East respiratory syndrome patient in a single Korean centre
      T. Kim, J. Jung, S.-M. Kim, D.-W. Seo, Y.S. Lee, W.Y. Kim, K.S. Lim, H. Sung, M.-N. Kim, Y.P. Chong, S.-O. Lee, S.-H. Choi, Y.S. Kim, J.H. Woo, S.-H. Kim
      Clinical Microbiology and Infection.2016; 22(2): e11.     CrossRef
    • Drivers of MERS-CoV transmission: what do we know?
      Jaffar A. Al-Tawfiq, Ziad A. Memish
      Expert Review of Respiratory Medicine.2016; 10(3): 331.     CrossRef
    • Vaccines for the prevention against the threat of MERS-CoV
      Lanying Du, Wanbo Tai, Yusen Zhou, Shibo Jiang
      Expert Review of Vaccines.2016; 15(9): 1123.     CrossRef
    • JSIPC in The Future, Based on Its History of 30 Years
      Kohya SHIBA
      Japanese Journal of Infection Prevention and Control.2016; 31(1): 1.     CrossRef
    • Emerging infectious diseases: Focus on infection control issues for novel coronaviruses (Severe Acute Respiratory Syndrome-CoV and Middle East Respiratory Syndrome-CoV), hemorrhagic fever viruses (Lassa and Ebola), and highly pathogenic avian influenza vi
      David J. Weber, William A. Rutala, William A. Fischer, Hajime Kanamori, Emily E. Sickbert-Bennett
      American Journal of Infection Control.2016; 44(5): e91.     CrossRef
    • Diagnosis for Imported Cases of Emerging and Reemerging Infectious Diseases in Korea
      Miae Lee
      The Ewha Medical Journal.2016; 39(2): 37.     CrossRef
    • Extensive Viable Middle East Respiratory Syndrome (MERS) Coronavirus Contamination in Air and Surrounding Environment in MERS Isolation Wards
      Sung-Han Kim, So Young Chang, Minki Sung, Ji Hoon Park, Hong Bin Kim, Heeyoung Lee, Jae-Phil Choi, Won Suk Choi, Ji-Young Min
      Clinical Infectious Diseases.2016; 63(3): 363.     CrossRef
    • Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015
      Jean-Louis Excler, Christopher J. Delvecchio, Ryan E. Wiley, Marni Williams, In-Kyu Yoon, Kayvon Modjarrad, Mohamed Boujelal, Vasee S. Moorthy, Ahmad Salah Hersi, Jerome H. Kim
      Emerging Infectious Diseases.2016;[Epub]     CrossRef
    • Outbreaks of Middle East Respiratory Syndrome in Two Hospitals Initiated by a Single Patient in Daejeon, South Korea
      Sun Hee Park, Yeon-Sook Kim, Younghee Jung, Soo young Choi, Nam-Hyuk Cho, Hye Won Jeong, Jung Yeon Heo, Ji Hyun Yoon, Jacob Lee, Shinhye Cheon, Kyung Mok Sohn
      Infection & Chemotherapy.2016; 48(2): 99.     CrossRef
    • Epidemiologic Parameters of the Middle East Respiratory Syndrome Outbreak in Korea, 2015
      Sun Hee Park, Woo Joo Kim, Jin-Hong Yoo, Jung-Hyun Choi
      Infection & Chemotherapy.2016; 48(2): 108.     CrossRef
    • Institutional Preparedness to Prevent Future Middle East Respiratory Syndrome Coronavirus-Like Outbreaks in Republic of Korea
      Min Huok Jeon, Tae Hyong Kim
      Infection & Chemotherapy.2016; 48(2): 75.     CrossRef
    • Contact Tracing for Imported Case of Middle East Respiratory Syndrome, China, 2015
      Min Kang, Tie Song, Haojie Zhong, Jie Hou, Jun Wang, Jiansen Li, Jie Wu, Jianfeng He, Jinyan Lin, Yonghhui Zhang
      Emerging Infectious Diseases.2016; 22(9): 1644.     CrossRef
    • The global spread of Middle East respiratory syndrome: an analysis fusing traditional epidemiological tracing and molecular phylodynamics
      Jae Min, Eleonora Cella, Massimo Ciccozzi, Antonello Pelosi, Marco Salemi, Mattia Prosperi
      Global Health Research and Policy.2016;[Epub]     CrossRef
    • MERS-CoV at the Animal–Human Interface: Inputs on Exposure Pathways from an Expert-Opinion Elicitation
      Anna L. Funk, Flavie Luce Goutard, Eve Miguel, Mathieu Bourgarel, Veronique Chevalier, Bernard Faye, J. S. Malik Peiris, Maria D. Van Kerkhove, Francois Louis Roger
      Frontiers in Veterinary Science.2016;[Epub]     CrossRef
    • A recombinant receptor-binding domain of MERS-CoV in trimeric form protects human dipeptidyl peptidase 4 (hDPP4) transgenic mice from MERS-CoV infection
      Wanbo Tai, Guangyu Zhao, Shihun Sun, Yan Guo, Yufei Wang, Xinrong Tao, Chien-Te K. Tseng, Fang Li, Shibo Jiang, Lanying, Du, Yusen Zhou
      Virology.2016; 499: 375.     CrossRef
    • The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study
      Hasan M. Al-Dorzi, Abdulaziz S. Aldawood, Raymond Khan, Salim Baharoon, John D. Alchin, Amal A. Matroud, Sameera M. Al Johany, Hanan H. Balkhy, Yaseen M. Arabi
      Annals of Intensive Care.2016;[Epub]     CrossRef
    • Preventive behaviors by the level of recognized sensitivity to infection during the MERS outbreak in 2015
      Soon Young Lee, Hee Jung Yang, Gawon Kim, Hae-Kwan Cheong, Bo Youl Choi
      Epidemiology and Health.2016; : e2016051.     CrossRef
    • Urgent Call for Research on Middle East Respiratory Syndrome (MERS) in Korea
      Sung-il Cho
      Journal of Preventive Medicine and Public Health.2015; 48(4): 179.     CrossRef
    • “The Duty to Prevent” during an epidemic situation like 2015 Korean MERS outbreak
      Jong-Myon Bae
      Epidemiology and Health.2015; 37: e2015037.     CrossRef
    • Epidemiologic features of the first MERS outbreak in Korea: focus on Pyeongtaek St. Mary’s Hospital
      Kyung Min Kim, Moran Ki, Sung-il Cho, Minki Sung, Jin Kwan Hong, Hae-Kwan Cheong, Jong-Hun Kim, Sang-Eun Lee, Changhwan Lee, Keon-Joo Lee, Yong-Shik Park, Seung Woo Kim, Bo Youl Choi
      Epidemiology and Health.2015; 37: e2015041.     CrossRef
    • Implementation of Quaternary Prevention in the Korean Healthcare System: Lessons From the 2015 Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea
      Jong-Myon Bae
      Journal of Preventive Medicine and Public Health.2015; 48(6): 271.     CrossRef
    • A New Measure for Assessing the Public Health Response to a Middle East Respiratory Syndrome Coronavirus Outbreak
      Sung-il Cho
      Journal of Preventive Medicine and Public Health.2015; 48(6): 277.     CrossRef
    • The first case of the 2015 Korean Middle East Respiratory Syndrome outbreak
      Yong-Shik Park, Changhwan Lee, Kyung Min Kim, Seung Woo Kim, Keon-Joo Lee, Jungmo Ahn, Moran Ki
      Epidemiology and Health.2015; 37: e2015049.     CrossRef
    • Epidemiology and challenges on the Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in Korea, 2015
      Moo-Sik Lee
      Korean Journal of Health Education and Promotion.2015; 32(3): 1.     CrossRef
    • Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials
      Sarah L. Warnes, Zoë R. Little, C. William Keevil, Rita Colwell
      mBio.2015;[Epub]     CrossRef

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    Epidemiol Health : Epidemiology and Health